Tag | Content |
---|---|
Uniprot ID | Q9EPS3; Q505E6; Q99MM0; |
Entrez ID | 93683 |
Genbank protein ID | AAH94587.1; AAG42004.1; EDL26018.1; AAK26246.1; |
Genbank nucleotide ID | XM_006511572.2; NM_033320.4; XM_006511571.2; |
Ensembl protein ID | ENSMUSP00000034785; ENSMUSP00000139949; |
Ensembl nucleotide ID | ENSMUSG00000032252 |
Gene name | D-glucuronyl C5-epimerase |
Gene symbol | Glce |
Organism | Mus musculus |
NCBI taxa ID | 10090 |
Cleft type | CPO |
Developmental stage | E14.5 |
Data sources | Manually collected |
Reference | 12788935 |
Functional description | Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. |
Sequence | MRCLAARVNY KTLIIICALF TLVTVLLWNK CSSDKAIQFP RHLSSGFRVD GLEKRSAASE 60 SNHYANHIAK QQSEEAFPQE QQKAPPVVGG FNSNGGSKVL GLKYEEIDCL INDEHTIKGR 120 REGNEVFLPF TWVEKYFDVY GKVVQYDGYD RFEFSHSYSK VYAQRSPYHP DGVFMSFEGY 180 NVEVRDRVKC ISGVEGVPLS TQWGPQGYFY PIQIAQYGLS HYSKNLTEKP PHIEVYETAE 240 DRDRNIRPNE WTVPKGCFMA SVADKSRSTN VKQFIAPETS EGVSLQLGNT KDFIISFDLK 300 LLTNGSVSVV LETTEKNQLF TVHYVSNTQL IAFRDRDIYY GIGPRTSWST VTRDLVTDLR 360 KGVGLSNTKA VKPTKIMPKK VVRLIAKGKG FLDNITISTT AHMAAFFAAS DWLVRNQDEK 420 GGWPIMVTRK LGEGFKSLEP GWYSAMAQGQ AISTLVRAYL LTKDYVFLSS ALRATAPYKF 480 PSEQHGVKAV FMNKHDWYEE YPTTPSSFVL NGFMYSLIGL YDLKETAGET LGKEARSLYE 540 RGMESLKAML PLYDTGSGTI YDLRHFMLGI APNLARWDYH TTHINQLQLL STIDESPIFK 600 EFVKRWKSYL KGSRAKHN 618 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
---|---|---|---|---|---|---|---|---|
1:1 ortholog | GLCE | 281195 | O18756 | Bos taurus | Prediction | More>> | ||
1:1 ortholog | GLCE | 102172900 | A0A452EMT4 | Capra hircus | Prediction | More>> | ||
1:1 ortholog | GLCE | F7CXB5 | Equus caballus | Prediction | More>> | |||
1:1 ortholog | GLCE | 26035 | O94923 | Homo sapiens | Prediction | More>> | ||
1:1 ortholog | Glce | 93683 | Q9EPS3 | CPO | E14.5 | Mus musculus | Publication | More>> |
1:1 ortholog | GLCE | 453542 | H2Q9P8 | Pan troglodytes | Prediction | More>> | ||
1:1 ortholog | GLCE | 100154444 | F1SIU0 | Sus scrofa | Prediction | More>> | ||
1:1 ortholog | Glce | 363073 | D3ZIK0 | Rattus norvegicus | Prediction | More>> | ||
1:1 ortholog | glceb | 100007670 | F1QR43 | Danio rerio | Prediction | More>> |
GO ID | GO Term | Evidence |
---|---|---|
GO:0005509 | calcium ion binding | ISS |
GO:0005509 | calcium ion binding | ISO |
GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives | IDA |
GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives | IMP |
GO:0042803 | protein homodimerization activity | ISS |
GO:0042803 | protein homodimerization activity | ISO |
GO:0047464 | heparosan-N-sulfate-glucuronate 5-epimerase activity | ISS |
GO:0047464 | heparosan-N-sulfate-glucuronate 5-epimerase activity | ISO |
GO:0050379 | UDP-glucuronate 5'-epimerase activity | TAS |
GO ID | GO Term | Evidence |
---|---|---|
GO:0015012 | heparan sulfate proteoglycan biosynthetic process | IEA |
GO:0015012 | heparan sulfate proteoglycan biosynthetic process | ISO |
GO:0015012 | heparan sulfate proteoglycan biosynthetic process | IDA |
GO:0030210 | heparin biosynthetic process | IEA |
GO:0030210 | heparin biosynthetic process | IDA |
GO ID | GO Term | Evidence |
---|---|---|
GO:0000139 | Golgi membrane | TAS |
GO:0005794 | Golgi apparatus | IDA |
GO:0016021 | integral component of membrane | IEA |
Reactome ID | Reactome Term | Evidence |
---|
Pfam ID | Pfam Term |
---|---|
PF06662 | C5-epim_C |