Gene: FZD7

Basic information

Tag Content
Uniprot ID F6XX91
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSCAFP00000031132
Ensembl nucleotide ID ENSCAFG00000012407
Gene name Frizzled class receptor 7
Gene symbol FZD7
Organism Canis lupus familiaris
NCBI taxa ID 9615
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MGGGEGAGRP GAPRARRFFW RVARLRGVTL RSLPAGGGGG GGGGRAGGRR DTRAGASRGW 60
RGQAQAAGSG PSRLRTQCDW ISKTNSLSSW LQSADRTRSE DRPLGRNLGA ELSGLEKERG 120
SRKGGGGGGG GGGGEQSLEA RRRSSTASAA ASARGRRRRL SPAGGRTRRG GRVRSRALWA 180
GRLWANFEGE PETLVAPRRG ERRTVTSPRE KAAAPVRAPG PGRRVRGSRR PPRCWAETAA 240
APPRRGHPGC SALSSAPPTP RPRRREDSHA PGAAAPPRIQ ASRGRVVALL GLRAPPHPWP 300
AMRGPGAAAA RSPLGLCTLA LALLGALPAG AGAQPYHGEK GISVPDHGFC QPISIPLCTD 360
IAYNQTILPN LLGHTNQEDA GLEVHQFYPL VKVQCSPELR FFLCSMYAPV CTVLDQAIPP 420
CRSLCERARQ GCEALMNKFG FQWPERLRCE NFPVHGAGEI CVGQNTSDGS GGAGGGPTAY 480
PTAPYMPDLP FTALPPGAAD GRGRAAFPFS CPRQLKVPPY LGYRFLGERD CGAPCEPGRA 540
NGLMYFKEEE RRFARLWVGV WSVLCCASTL FTVLTYLVDM RRFSYPERPI IFLSGCYFMV 600
AVAHVAGFLL EDRAVCVERF SDDGYRTVAQ GTKKEGCTIL FMVLYFFGMA SSIWWVILSL 660
TWFLAAGMKW GHEAIEANSQ YFHLAAWAVP AVKTITILAM GQVDGDLLSG VCYVGLSSVD 720
ALRGFVLAPL FVYLFIGTSF LLAGFVSLFR IRTIMKHDGT KTEKLEKLMV RIGVFSVLYT 780
VPATIVLACY FYEQAFREHW ERTWLLQTCK SYAVPCPPGH FPPMSPDFTV FMIKYLMTMI 840
VGITTGFWIW SGKTLQSWRR FYHRLSHSSK GETAACSHGW CVLQTHRRKT SDSPHQEEEA 900
TPLHSVQSIF

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologFZD7524255F1N4K7Bos taurusPredictionMore>>
1:1 orthologFZD7F6XX91Canis lupus familiarisPredictionMore>>
1:1 orthologFZD7A0A452G725Capra hircusPredictionMore>>
1:1 orthologFZD78324O75084Homo sapiensPredictionMore>>
1:1 orthologFzd714369Q61090CPOE14.5Mus musculusPublicationMore>>
1:1 orthologFZD7459881A0A2I3TGC6Pan troglodytesPredictionMore>>
1:1 orthologFZD7F1SI18Sus scrofaPredictionMore>>
1:1 orthologFzd7100360552D4ACM8Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0016021 integral component of membrane
GO:0005886 plasma membrane
GO:0042813 Wnt-activated receptor activity
GO:0017147 Wnt-protein binding
GO:0060070 canonical Wnt signaling pathway
GO:0007275 multicellular organism development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0217 Developmental protein
KW-1015 Disulfide bond
KW-0472 Membrane
KW-0675 Receptor
KW-1185 Reference proteome
KW-0812 Transmembrane
KW-1133 Transmembrane helix
KW-0879 Wnt signaling pathway

Interpro

InterPro ID InterPro Term
IPR042742 Frizzled-7_CRD
IPR015526 Frizzled/SFRP
IPR000539 Frizzled/Smoothened_TM
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR026552 FZD7
IPR017981 GPCR_2-like

PROSITE

PROSITE ID PROSITE Term
PS50038 FZ
PS50261 G_PROTEIN_RECEP_F2_4

Pfam

Pfam ID Pfam Term
PF01534 Frizzled
PF01392 Fz