| Tag | Content |
|---|---|
| Uniprot ID | Q61090; G3X953; |
| Entrez ID | 14369 |
| Genbank protein ID | AAC52432.1; EDL00127.1; |
| Genbank nucleotide ID | NM_008057.3 |
| Ensembl protein ID | ENSMUSP00000109884 |
| Ensembl nucleotide ID | ENSMUSG00000041075 |
| Gene name | Frizzled-7 |
| Gene symbol | Fzd7 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E14.5 |
| Data sources | Manually collected |
| Reference | 23095888 |
| Functional description | Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes. Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses (By similarity). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
| Sequence | MRGPGTAASH SPLGLCALVL ALLGALPTDT RAQPYHGEKG ISVPDHGFCQ PISIPLCTDI 60 AYNQTILPNL LGHTNQEDAG LEVHQFYPLV KVQCSPELRF FLCSMYAPVC TVLDQAIPPC 120 RSLCERARQG CEALMNKFGF QWPERLRCEN FPVHGAGEIC VGQNTSDGSG GAGGSPTAYP 180 TAPYLPDPPF TAMSPSDGRG RLSFPFSCPR QLKVPPYLGY RFLGERDCGA PCEPGRANGL 240 MYFKEEERRF ARLWVGVWSV LCCASTLFTV LTYLVDMRRF SYPERPIIFL SGCYFMVAVA 300 HVAGFLLEDR AVCVERFSDD GYRTVAQGTK KEGCTILFMV LYFFGMASSI WWVILSLTWF 360 LAAGMKWGHE AIEANSQYFH LAAWAVPAVK TITILAMGQV DGDLLSGVCY VGLSSVDALR 420 GFVLAPLFVY LFIGTSFLLA GFVSLFRIRT IMKHDGTKTE KLEKLMVRIG VFSVLYTVPA 480 TIVLACYFYE QAFREHWERT WLLQTCKSYA VPCPPGHFSP MSPDFTVFMI KYLMTMIVGI 540 TTGFWIWSGK TLQSWRRFYH RLSHSSKGET AV 572 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FZD7 | 524255 | F1N4K7 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | FZD7 | F6XX91 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | FZD7 | A0A452G725 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | FZD7 | 8324 | O75084 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Fzd7 | 14369 | Q61090 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | FZD7 | 459881 | A0A2I3TGC6 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | FZD7 | F1SI18 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Fzd7 | 100360552 | D4ACM8 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | IEA |
| GO:0005109 | frizzled binding | ISO |
| GO:0005515 | protein binding | IPI |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | ISO |
| GO:0017147 | Wnt-protein binding | ISO |
| GO:0017147 | Wnt-protein binding | IPI |
| GO:0017147 | Wnt-protein binding | IBA |
| GO:0030165 | PDZ domain binding | ISO |
| GO:0042813 | Wnt-activated receptor activity | ISO |
| GO:0042813 | Wnt-activated receptor activity | IMP |
| GO:0042813 | Wnt-activated receptor activity | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0006355 | regulation of transcription, DNA-templated | ISO |
| GO:0007186 | G protein-coupled receptor signaling pathway | IEA |
| GO:0010812 | negative regulation of cell-substrate adhesion | ISO |
| GO:0010812 | negative regulation of cell-substrate adhesion | IMP |
| GO:0014834 | skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration | IMP |
| GO:0019827 | stem cell population maintenance | ISO |
| GO:0033077 | T cell differentiation in thymus | IMP |
| GO:0034446 | substrate adhesion-dependent cell spreading | IMP |
| GO:0035567 | non-canonical Wnt signaling pathway | IGI |
| GO:0038031 | non-canonical Wnt signaling pathway via JNK cascade | ISO |
| GO:0042327 | positive regulation of phosphorylation | ISO |
| GO:0042666 | negative regulation of ectodermal cell fate specification | ISO |
| GO:0045893 | positive regulation of transcription, DNA-templated | ISO |
| GO:0048103 | somatic stem cell division | IMP |
| GO:0060054 | positive regulation of epithelial cell proliferation involved in wound healing | ISO |
| GO:0060070 | canonical Wnt signaling pathway | ISO |
| GO:0060070 | canonical Wnt signaling pathway | IMP |
| GO:0060070 | canonical Wnt signaling pathway | IGI |
| GO:0060070 | canonical Wnt signaling pathway | IBA |
| GO:0060231 | mesenchymal to epithelial transition | ISO |
| GO:0060828 | regulation of canonical Wnt signaling pathway | ISO |
| GO:2000726 | negative regulation of cardiac muscle cell differentiation | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | IDA |
| GO:0005886 | plasma membrane | IMP |
| GO:0005886 | plasma membrane | IBA |
| GO:0005886 | plasma membrane | TAS |
| GO:0016021 | integral component of membrane | IBA |
| GO:0043231 | intracellular membrane-bounded organelle | ISO |
| GO:0055038 | recycling endosome membrane | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-195721 | Signaling by WNT | IEA |
| R-MMU-3858494 | Beta-catenin independent WNT signaling | IEA |
| R-MMU-4086400 | PCP/CE pathway | IEA |
| R-MMU-4608870 | Asymmetric localization of PCP proteins | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-1003 | Cell membrane |
| KW-0217 | Developmental protein |
| KW-1015 | Disulfide bond |
| KW-0967 | Endosome |
| KW-0297 | G-protein coupled receptor |
| KW-0325 | Glycoprotein |
| KW-0472 | Membrane |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0732 | Signal |
| KW-0807 | Transducer |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0832 | Ubl conjugation |
| KW-0879 | Wnt signaling pathway |