| Tag | Content |
|---|---|
| Uniprot ID | F8W4A6 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000123937 |
| Ensembl nucleotide ID | ENSDARG00000027087 |
| Gene name | Latency-associated peptide |
| Gene symbol | tgfb2 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. |
| Sequence | TNMNLYVLSL LLLLDLAAVA VSLSTCSTLD MDQFKKKRIE AIRGQILSKL KLSSPPEIYP 60 EPEEVSRDII AIYNSTRDLL QEKANERAAT CERQRSEEEY YAKEVHKIDM QPFYPSENVI 120 LSQHYYPYFR RLMFDVSSME KNASNLVKAE LRIFRLQNPK ARVSEQRIEL YQVLGHKDLT 180 SPTQRYINSK VVRTRTEGEW LSFDVTEAVS EWLLHRDRNK GFKISLHCPC CTFVPSNNYI 240 IPNKSEELET RFAGIDDSFV NGGDLKMFKK RRHSGQSPHL LLMLLPSYRL ESQHKSHRQK 300 RALDTAFCSR NVQDNCCLRS LYIDFKKDLG WRWIHEPKGY NANFCAGACP YLWSADTQHS 360 NILGLYNTIN PEASASPCCV SQDLEPLTIL YYIGKTPKIE QLSNMIVKSC KCS 413 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TGFB2 | 534069 | P21214 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TGFB2 | 488596 | F1PKH2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | TGFB2 | 100861228 | A0A452FPN4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TGFB2 | 100050377 | F6WJJ3 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | TGFB2 | 7042 | P61812 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Tgfb2 | 21808 | P27090 | CPO | E12.5, E14.0, E13.5, E14.5, E15.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | TGFB2 | A0A2I3S6G8 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | TGFB2 | F1S9L0 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | TGFB2 | G1SNK8 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Tgfb2 | G3V6B1 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | tgfb2 | F8W4A6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0005125 | cytokine activity |
| GO:0008083 | growth factor activity |
| GO:0005114 | type II transforming growth factor beta receptor binding |
| GO:0034714 | type III transforming growth factor beta receptor binding |
| GO:0030509 | BMP signaling pathway |
| GO:0051781 | positive regulation of cell division |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0042127 | regulation of cell population proliferation |
| GO:0060021 | roof of mouth development |
| GO:0061056 | sclerotome development |
| GO:0060395 | SMAD protein signal transduction |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |