Gene: TGFB2

Basic information

Tag Content
Uniprot ID P21214
Entrez ID 534069
Genbank protein ID
Genbank nucleotide ID NM_001113252.1
Ensembl protein ID ENSBTAP00000007053
Ensembl nucleotide ID ENSBTAG00000005359
Gene name Transforming growth factor beta-2 proprotein
Gene symbol TGFB2
Organism Bos taurus
NCBI taxa ID 9913
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
Sequence
MHYCVLSAFL LLHLVTVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL TSPPEDYPEP 60
EEVPPEVISI YNSTRDLLQE KASRRAAACE RERSDEEYYA KEVYKIDMPS FLPSENAIPP 120
TFYRPYFRIV RFDVSSMEKN ASNLVKAEFR VFRLQNPKAR VPEQRIELYQ ILKSKDLTSP 180
TQRYIDSKVV KTRAEGEWLS FDVTDAVHEW LHHKDRNLGF KISLHCPCCT FVPSNNYIIP 240
NKSEELEARF AGIDGTSTYT SGDQKTIKST RKKNSGKSPH LLLMLLPSYR LESQQSNRRK 300
KRALDAAYCF RNVQDNCCLR PLYIDFKRDL GWKWIHEPKG YNANFCAGAC PYLWSSDTQH 360
SRVLSLYNTI NPEASASPCC VSQDLEPLTI LYYIGKTPKI EQLSNMIVKS CKCS 414

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologTGFB2534069P21214Bos taurusPredictionMore>>
1:1 orthologTGFB2488596F1PKH2Canis lupus familiarisPredictionMore>>
1:1 orthologTGFB2100861228A0A452FPN4Capra hircusPredictionMore>>
1:1 orthologTGFB2100050377F6WJJ3Equus caballusPredictionMore>>
1:1 orthologTGFB27042P61812Homo sapiensPublicationMore>>
1:1 orthologTgfb221808P27090CPOE12.5, E14.0, E13.5, E14.5, E15.5Mus musculusPublicationMore>>
1:1 orthologTGFB2A0A2I3S6G8Pan troglodytesPredictionMore>>
1:1 orthologTGFB2F1S9L0Sus scrofaPredictionMore>>
1:1 orthologTGFB2G1SNK8Oryctolagus cuniculusPredictionMore>>
1:1 orthologTgfb2G3V6B1Rattus norvegicusPredictionMore>>
1:1 orthologtgfb2F8W4A6Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0031012 extracellular matrix
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0001540 amyloid-beta binding
GO:0005125 cytokine activity
GO:0008083 growth factor activity
GO:0042803 protein homodimerization activity
GO:0005102 signaling receptor binding
GO:0005160 transforming growth factor beta receptor binding
GO:0005114 type II transforming growth factor beta receptor binding
GO:0034714 type III transforming growth factor beta receptor binding
GO:0032147 activation of protein kinase activity
GO:0030509 BMP signaling pathway
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060038 cardiac muscle cell proliferation
GO:0010002 cardioblast differentiation
GO:0007050 cell cycle arrest
GO:0008219 cell death
GO:0016477 cell migration
GO:0000902 cell morphogenesis
GO:0045216 cell-cell junction organization
GO:0030199 collagen fibril organization
GO:0048566 embryonic digestive tract development
GO:0001837 epithelial to mesenchymal transition
GO:0097191 extrinsic apoptotic signaling pathway
GO:0001654 eye development
GO:0008347 glial cell migration
GO:0001942 hair follicle development
GO:0007507 heart development
GO:0003007 heart morphogenesis
GO:0010693 negative regulation of alkaline phosphatase activity
GO:0030308 negative regulation of cell growth
GO:0008285 negative regulation of cell population proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0010936 negative regulation of macrophage cytokine production
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0051891 positive regulation of cardioblast differentiation
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0051781 positive regulation of cell division
GO:0030307 positive regulation of cell growth
GO:0008284 positive regulation of cell population proliferation
GO:0010634 positive regulation of epithelial cell migration
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0045823 positive regulation of heart contraction
GO:0045726 positive regulation of integrin biosynthetic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045778 positive regulation of ossification
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0050714 positive regulation of protein secretion
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0051795 positive regulation of timing of catagen
GO:0006468 protein phosphorylation
GO:0042127 regulation of cell population proliferation
GO:0032909 regulation of transforming growth factor beta2 production
GO:0042493 response to drug
GO:0032570 response to progesterone
GO:0009611 response to wounding
GO:0007435 salivary gland morphogenesis
GO:0023014 signal transduction by protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0165 Cleavage on pair of basic residues
KW-0903 Direct protein sequencing
KW-1015 Disulfide bond
KW-0272 Extracellular matrix
KW-0325 Glycoprotein
KW-0339 Growth factor
KW-0497 Mitogen
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR016319 TGF-beta
IPR015615 TGF-beta-rel
IPR003940 TGFb2
IPR017948 TGFb_CS

PROSITE

PROSITE ID PROSITE Term
PS00250 TGF_BETA_1
PS51362 TGF_BETA_2

Pfam

Pfam ID Pfam Term
PF00019 TGF_beta
PF00688 TGFb_propeptide