| Tag | Content |
|---|---|
| Uniprot ID | P21214 |
| Entrez ID | 534069 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001113252.1 |
| Ensembl protein ID | ENSBTAP00000007053 |
| Ensembl nucleotide ID | ENSBTAG00000005359 |
| Gene name | Transforming growth factor beta-2 proprotein |
| Gene symbol | TGFB2 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. |
| Sequence | MHYCVLSAFL LLHLVTVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL TSPPEDYPEP 60 EEVPPEVISI YNSTRDLLQE KASRRAAACE RERSDEEYYA KEVYKIDMPS FLPSENAIPP 120 TFYRPYFRIV RFDVSSMEKN ASNLVKAEFR VFRLQNPKAR VPEQRIELYQ ILKSKDLTSP 180 TQRYIDSKVV KTRAEGEWLS FDVTDAVHEW LHHKDRNLGF KISLHCPCCT FVPSNNYIIP 240 NKSEELEARF AGIDGTSTYT SGDQKTIKST RKKNSGKSPH LLLMLLPSYR LESQQSNRRK 300 KRALDAAYCF RNVQDNCCLR PLYIDFKRDL GWKWIHEPKG YNANFCAGAC PYLWSSDTQH 360 SRVLSLYNTI NPEASASPCC VSQDLEPLTI LYYIGKTPKI EQLSNMIVKS CKCS 414 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TGFB2 | 534069 | P21214 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | TGFB2 | 488596 | F1PKH2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | TGFB2 | 100861228 | A0A452FPN4 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TGFB2 | 100050377 | F6WJJ3 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | TGFB2 | 7042 | P61812 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Tgfb2 | 21808 | P27090 | CPO | E12.5, E14.0, E13.5, E14.5, E15.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | TGFB2 | A0A2I3S6G8 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | TGFB2 | F1S9L0 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | TGFB2 | G1SNK8 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Tgfb2 | G3V6B1 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | tgfb2 | F8W4A6 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031012 | extracellular matrix |
| GO:0005576 | extracellular region |
| GO:0005615 | extracellular space |
| GO:0001540 | amyloid-beta binding |
| GO:0005125 | cytokine activity |
| GO:0008083 | growth factor activity |
| GO:0042803 | protein homodimerization activity |
| GO:0005102 | signaling receptor binding |
| GO:0005160 | transforming growth factor beta receptor binding |
| GO:0005114 | type II transforming growth factor beta receptor binding |
| GO:0034714 | type III transforming growth factor beta receptor binding |
| GO:0032147 | activation of protein kinase activity |
| GO:0030509 | BMP signaling pathway |
| GO:0060317 | cardiac epithelial to mesenchymal transition |
| GO:0060038 | cardiac muscle cell proliferation |
| GO:0010002 | cardioblast differentiation |
| GO:0007050 | cell cycle arrest |
| GO:0008219 | cell death |
| GO:0016477 | cell migration |
| GO:0000902 | cell morphogenesis |
| GO:0045216 | cell-cell junction organization |
| GO:0030199 | collagen fibril organization |
| GO:0048566 | embryonic digestive tract development |
| GO:0001837 | epithelial to mesenchymal transition |
| GO:0097191 | extrinsic apoptotic signaling pathway |
| GO:0001654 | eye development |
| GO:0008347 | glial cell migration |
| GO:0001942 | hair follicle development |
| GO:0007507 | heart development |
| GO:0003007 | heart morphogenesis |
| GO:0010693 | negative regulation of alkaline phosphatase activity |
| GO:0030308 | negative regulation of cell growth |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0050680 | negative regulation of epithelial cell proliferation |
| GO:0010936 | negative regulation of macrophage cytokine production |
| GO:0060389 | pathway-restricted SMAD protein phosphorylation |
| GO:0051891 | positive regulation of cardioblast differentiation |
| GO:0033630 | positive regulation of cell adhesion mediated by integrin |
| GO:0051781 | positive regulation of cell division |
| GO:0030307 | positive regulation of cell growth |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0010634 | positive regulation of epithelial cell migration |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| GO:0045823 | positive regulation of heart contraction |
| GO:0045726 | positive regulation of integrin biosynthetic process |
| GO:0043525 | positive regulation of neuron apoptotic process |
| GO:0045778 | positive regulation of ossification |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| GO:0050714 | positive regulation of protein secretion |
| GO:0032874 | positive regulation of stress-activated MAPK cascade |
| GO:0051795 | positive regulation of timing of catagen |
| GO:0006468 | protein phosphorylation |
| GO:0042127 | regulation of cell population proliferation |
| GO:0032909 | regulation of transforming growth factor beta2 production |
| GO:0042493 | response to drug |
| GO:0032570 | response to progesterone |
| GO:0009611 | response to wounding |
| GO:0007435 | salivary gland morphogenesis |
| GO:0023014 | signal transduction by protein phosphorylation |
| GO:0060395 | SMAD protein signal transduction |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |