CleftGeneDB-Search

Gene: Tgfb2

Basic information

Tag	Content
Uniprot ID	P27090; Q91VP5;
Entrez ID	21808
Genbank protein ID	AAH11170.1; CAA40672.1;
Genbank nucleotide ID	NM_009367.4
Ensembl protein ID	ENSMUSP00000043849
Ensembl nucleotide ID	ENSMUSG00000039239
Gene name	Transforming growth factor beta-2 proprotein
Gene symbol	Tgfb2
Organism	Mus musculus
NCBI taxa ID	10090
Cleft type	CPO
Developmental stage	E12.5, E14.0, E13.5, E14.5, E15.5
Data sources	Manually collected
Reference	9217007
Functional description	Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
Sequence	MHYCVLSTFL LLHLVPVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL TSPPEDYPEP 60 DEVPPEVISI YNSTRDLLQE KASRRAAACE RERSDEEYYA KEVYKIDMPS HLPSENAIPP 120 TFYRPYFRIV RFDVSTMEKN ASNLVKAEFR VFRLQNPKAR VAEQRIELYQ ILKSKDLTSP 180 TQRYIDSKVV KTRAEGEWLS FDVTDAVQEW LHHKDRNLGF KISLHCPCCT FVPSNNYIIP 240 NKSEELEARF AGIDGTSTYA SGDQKTIKST RKKTSGKTPH LLLMLLPSYR LESQQSSRRK 300 KRALDAAYCF RNVQDNCCLR PLYIDFKRDL GWKWIHEPKG YNANFCAGAC PYLWSSDTQH 360 TKVLSLYNTI NPEASASPCC VSQDLEPLTI LYYIGNTPKI EQLSNMIVKS CKCS 414

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

Protein structural annotations

3D structure in PDB database

PDB ID
5TX2
5TX6

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Developmental stage	Species	Evidence	Details
1:1 ortholog	TGFB2	534069	P21214			Bos taurus	Prediction	More>>
1:1 ortholog	TGFB2	488596	F1PKH2			Canis lupus familiaris	Prediction	More>>
1:1 ortholog	TGFB2	100861228	A0A452FPN4			Capra hircus	Prediction	More>>
1:1 ortholog	TGFB2	100050377	F6WJJ3			Equus caballus	Prediction	More>>
1:1 ortholog	TGFB2	7042	P61812			Homo sapiens	Publication	More>>
1:1 ortholog	Tgfb2	21808	P27090	CPO	E12.5, E14.0, E13.5, E14.5, E15.5	Mus musculus	Publication	More>>
1:1 ortholog	TGFB2		A0A2I3S6G8			Pan troglodytes	Prediction	More>>
1:1 ortholog	TGFB2		F1S9L0			Sus scrofa	Prediction	More>>
1:1 ortholog	TGFB2		G1SNK8			Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Tgfb2		G3V6B1			Rattus norvegicus	Prediction	More>>
1:1 ortholog	tgfb2		F8W4A6			Danio rerio	Prediction	More>>

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0001540	amyloid-beta binding	ISS
GO:0001540	amyloid-beta binding	ISO
GO:0005102	signaling receptor binding	ISS
GO:0005102	signaling receptor binding	ISO
GO:0005114	type II transforming growth factor beta receptor binding	ISS
GO:0005114	type II transforming growth factor beta receptor binding	ISO
GO:0005114	type II transforming growth factor beta receptor binding	IBA
GO:0005125	cytokine activity	IBA
GO:0005160	transforming growth factor beta receptor binding	ISS
GO:0005160	transforming growth factor beta receptor binding	ISO
GO:0005515	protein binding	IPI
GO:0008083	growth factor activity	TAS
GO:0034714	type III transforming growth factor beta receptor binding	ISS
GO:0034714	type III transforming growth factor beta receptor binding	ISO
GO:0034714	type III transforming growth factor beta receptor binding	IBA
GO:0042802	identical protein binding	ISO
GO:0042803	protein homodimerization activity	ISS
GO:0042803	protein homodimerization activity	ISO
GO:0044877	protein-containing complex binding	ISO
GO:0047485	protein N-terminus binding	ISO

GO:Biological Process

GO ID	GO Term	Evidence
GO:0000902	cell morphogenesis	ISS
GO:0000902	cell morphogenesis	ISO
GO:0001501	skeletal system development	IMP
GO:0001502	cartilage condensation	IGI
GO:0001568	blood vessel development	IMP
GO:0001654	eye development	ISS
GO:0001654	eye development	ISO
GO:0001666	response to hypoxia	ISS
GO:0001666	response to hypoxia	ISO
GO:0001822	kidney development	IMP
GO:0001837	epithelial to mesenchymal transition	ISS
GO:0001837	epithelial to mesenchymal transition	ISO
GO:0001843	neural tube closure	IMP
GO:0001942	hair follicle development	ISS
GO:0001942	hair follicle development	ISO
GO:0001942	hair follicle development	IMP
GO:0001974	blood vessel remodeling	IMP
GO:0003007	heart morphogenesis	ISS
GO:0003007	heart morphogenesis	ISO
GO:0003148	outflow tract septum morphogenesis	IMP
GO:0003149	membranous septum morphogenesis	IMP
GO:0003151	outflow tract morphogenesis	TAS
GO:0003179	heart valve morphogenesis	IMP
GO:0003181	atrioventricular valve morphogenesis	IMP
GO:0003184	pulmonary valve morphogenesis	IMP
GO:0003203	endocardial cushion morphogenesis	IMP
GO:0003214	cardiac left ventricle morphogenesis	TAS
GO:0003215	cardiac right ventricle morphogenesis	TAS
GO:0003215	cardiac right ventricle morphogenesis	IMP
GO:0003222	ventricular trabecula myocardium morphogenesis	IMP
GO:0003274	endocardial cushion fusion	IMP
GO:0003289	atrial septum primum morphogenesis	IMP
GO:0003407	neural retina development	IMP
GO:0006468	protein phosphorylation	ISS
GO:0006468	protein phosphorylation	ISO
GO:0007050	cell cycle arrest	ISS
GO:0007050	cell cycle arrest	ISO
GO:0007179	transforming growth factor beta receptor signaling pathway	ISS
GO:0007179	transforming growth factor beta receptor signaling pathway	ISO
GO:0007179	transforming growth factor beta receptor signaling pathway	IBA
GO:0007411	axon guidance	IMP
GO:0007435	salivary gland morphogenesis	ISS
GO:0007507	heart development	ISS
GO:0007507	heart development	ISO
GO:0007507	heart development	IMP
GO:0008219	cell death	ISS
GO:0008219	cell death	ISO
GO:0008284	positive regulation of cell population proliferation	ISS
GO:0008284	positive regulation of cell population proliferation	ISO
GO:0008285	negative regulation of cell population proliferation	ISS
GO:0008285	negative regulation of cell population proliferation	ISO
GO:0008347	glial cell migration	ISS
GO:0008347	glial cell migration	ISO
GO:0008584	male gonad development	IMP
GO:0009611	response to wounding	ISS
GO:0010002	cardioblast differentiation	ISS
GO:0010002	cardioblast differentiation	ISO
GO:0010628	positive regulation of gene expression	IDA
GO:0010629	negative regulation of gene expression	ISO
GO:0010629	negative regulation of gene expression	IDA
GO:0010634	positive regulation of epithelial cell migration	ISS
GO:0010634	positive regulation of epithelial cell migration	ISO
GO:0010693	negative regulation of alkaline phosphatase activity	ISS
GO:0010693	negative regulation of alkaline phosphatase activity	ISO
GO:0010718	positive regulation of epithelial to mesenchymal transition	ISS
GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	IBA
GO:0010936	negative regulation of macrophage cytokine production	ISS
GO:0010936	negative regulation of macrophage cytokine production	ISO
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISS
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO
GO:0016477	cell migration	ISS
GO:0016477	cell migration	ISO
GO:0016525	negative regulation of angiogenesis	ISO
GO:0030097	hemopoiesis	IMP
GO:0030198	extracellular matrix organization	IMP
GO:0030199	collagen fibril organization	ISS
GO:0030199	collagen fibril organization	ISO
GO:0030307	positive regulation of cell growth	ISS
GO:0030307	positive regulation of cell growth	ISO
GO:0030308	negative regulation of cell growth	ISS
GO:0030308	negative regulation of cell growth	ISO
GO:0030326	embryonic limb morphogenesis	IMP
GO:0030335	positive regulation of cell migration	ISO
GO:0030509	BMP signaling pathway	IBA
GO:0030593	neutrophil chemotaxis	ISS
GO:0031069	hair follicle morphogenesis	IMP
GO:0032147	activation of protein kinase activity	ISS
GO:0032147	activation of protein kinase activity	ISO
GO:0032570	response to progesterone	ISS
GO:0032570	response to progesterone	ISO
GO:0032874	positive regulation of stress-activated MAPK cascade	ISS
GO:0032874	positive regulation of stress-activated MAPK cascade	ISO
GO:0032909	regulation of transforming growth factor beta2 production	ISS
GO:0032909	regulation of transforming growth factor beta2 production	ISO
GO:0032956	regulation of actin cytoskeleton organization	IDA
GO:0033630	positive regulation of cell adhesion mediated by integrin	ISS
GO:0033630	positive regulation of cell adhesion mediated by integrin	ISO
GO:0035910	ascending aorta morphogenesis	IMP
GO:0042060	wound healing	ISS
GO:0042060	wound healing	ISO
GO:0042127	regulation of cell population proliferation	IBA
GO:0042416	dopamine biosynthetic process	IMP
GO:0042493	response to drug	ISS
GO:0042493	response to drug	ISO
GO:0042981	regulation of apoptotic process	IMP
GO:0043065	positive regulation of apoptotic process	ISO
GO:0043066	negative regulation of apoptotic process	ISO
GO:0043525	positive regulation of neuron apoptotic process	ISS
GO:0043525	positive regulation of neuron apoptotic process	ISO
GO:0043627	response to estrogen	ISO
GO:0045216	cell-cell junction organization	ISS
GO:0045216	cell-cell junction organization	ISO
GO:0045617	negative regulation of keratinocyte differentiation	NAS
GO:0045726	positive regulation of integrin biosynthetic process	ISS
GO:0045726	positive regulation of integrin biosynthetic process	ISO
GO:0045747	positive regulation of Notch signaling pathway	ISO
GO:0045778	positive regulation of ossification	ISS
GO:0045787	positive regulation of cell cycle	IMP
GO:0045823	positive regulation of heart contraction	ISS
GO:0045823	positive regulation of heart contraction	ISO
GO:0046580	negative regulation of Ras protein signal transduction	IMP
GO:0048103	somatic stem cell division	IDA
GO:0048566	embryonic digestive tract development	ISS
GO:0048663	neuron fate commitment	IDA
GO:0048666	neuron development	IMP
GO:0048702	embryonic neurocranium morphogenesis	ISO
GO:0048839	inner ear development	IMP
GO:0050680	negative regulation of epithelial cell proliferation	ISS
GO:0050680	negative regulation of epithelial cell proliferation	ISO
GO:0050714	positive regulation of protein secretion	ISS
GO:0050714	positive regulation of protein secretion	ISO
GO:0050777	negative regulation of immune response	ISO
GO:0050778	positive regulation of immune response	ISS
GO:0051280	negative regulation of release of sequestered calcium ion into cytosol	ISO
GO:0051781	positive regulation of cell division	IEA
GO:0051794	regulation of timing of catagen	ISS
GO:0051794	regulation of timing of catagen	ISO
GO:0051795	positive regulation of timing of catagen	ISS
GO:0051795	positive regulation of timing of catagen	ISO
GO:0051891	positive regulation of cardioblast differentiation	ISS
GO:0051891	positive regulation of cardioblast differentiation	ISO
GO:0060038	cardiac muscle cell proliferation	ISS
GO:0060038	cardiac muscle cell proliferation	ISO
GO:0060065	uterus development	IMP
GO:0060317	cardiac epithelial to mesenchymal transition	ISS
GO:0060317	cardiac epithelial to mesenchymal transition	ISO
GO:0060325	face morphogenesis	IEP
GO:0060389	pathway-restricted SMAD protein phosphorylation	ISO
GO:0060389	pathway-restricted SMAD protein phosphorylation	IDA
GO:0060395	SMAD protein signal transduction	ISS
GO:0060395	SMAD protein signal transduction	ISO
GO:0060395	SMAD protein signal transduction	IBA
GO:0060412	ventricular septum morphogenesis	TAS
GO:0060412	ventricular septum morphogenesis	IMP
GO:0060413	atrial septum morphogenesis	IMP
GO:0061037	negative regulation of cartilage development	IMP
GO:0061626	pharyngeal arch artery morphogenesis	IMP
GO:0062009	secondary palate development	IMP
GO:0070237	positive regulation of activation-induced cell death of T cells	IDA
GO:0090091	positive regulation of extracellular matrix disassembly	IDA
GO:0097191	extrinsic apoptotic signaling pathway	ISS
GO:0097191	extrinsic apoptotic signaling pathway	ISO
GO:1900182	positive regulation of protein localization to nucleus	IDA
GO:1902256	regulation of apoptotic process involved in outflow tract morphogenesis	IMP
GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	ISO
GO:1903053	regulation of extracellular matrix organization	IMP
GO:1903701	substantia propria of cornea development	IMP
GO:1904426	positive regulation of GTP binding	IDA
GO:1904888	cranial skeletal system development	IMP
GO:1905006	negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IMP
GO:1905007	positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IMP
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005576	extracellular region	ISS
GO:0005576	extracellular region	ISO
GO:0005604	basement membrane	ISO
GO:0005615	extracellular space	ISO
GO:0005615	extracellular space	IBA
GO:0005615	extracellular space	HDA
GO:0005615	extracellular space	IDA
GO:0005737	cytoplasm	ISO
GO:0005768	endosome	IDA
GO:0005802	trans-Golgi network	ISO
GO:0009986	cell surface	ISO
GO:0030141	secretory granule	ISO
GO:0030424	axon	IDA
GO:0031012	extracellular matrix	ISS
GO:0043025	neuronal cell body	IDA
GO:0062023	collagen-containing extracellular matrix	ISO

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-MMU-109582	Hemostasis	IEA
R-MMU-114608	Platelet degranulation	IEA
R-MMU-1474244	Extracellular matrix organization	IEA
R-MMU-1566948	Elastic fibre formation	IEA
R-MMU-2129379	Molecules associated with elastic fibres	IEA
R-MMU-76002	Platelet activation, signaling and aggregation	IEA
R-MMU-76005	Response to elevated platelet cytosolic Ca2+	IEA

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0165	Cleavage on pair of basic residues
KW-1015	Disulfide bond
KW-0272	Extracellular matrix
KW-0325	Glycoprotein
KW-0339	Growth factor
KW-0497	Mitogen
KW-1185	Reference proteome
KW-0964	Secreted
KW-0732	Signal

Interpro

InterPro ID	InterPro Term
IPR029034	Cystine-knot_cytokine
IPR001839	TGF-b_C
IPR001111	TGF-b_propeptide
IPR016319	TGF-beta
IPR015615	TGF-beta-rel
IPR003940	TGFb2
IPR017948	TGFb_CS

PROSITE

PROSITE ID	PROSITE Term
PS00250	TGF_BETA_1
PS51362	TGF_BETA_2

Pfam

Pfam ID	Pfam Term
PF00019	TGF_beta
PF00688	TGFb_propeptide

Gene: Tgfb2

Basic information

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction