Gene: INSIG2

Basic information

Tag Content
Uniprot ID G1DGF2
Entrez ID 100861144
Genbank protein ID AEJ84356.1; AFC93421.1;
Genbank nucleotide ID NM_001285738.1
Ensembl protein ID ENSCHIP00000018530; ENSCHIP00000018535;
Ensembl nucleotide ID ENSCHIG00000017903
Gene name Insulin-induced gene protein
Gene symbol INSIG2
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Mediates feedback control of cholesterol synthesis.
Sequence
MAEGETESPG PKKRGPYISS VTSRSVNLMI RGVVLFFIGV FLALVLNLLQ IQRNVTLFPP 60
DVIASIFSSA WWVPPCCGTA SAVIGLLYPC IDRHLGEPHK FKREWSSVMR CVAVFVGINH 120
ASAKVDFDNN IQLSLTLAAL SIGLWWTFDR SRSGFGLGIG IAFLATVVTQ LLVYNGVYQY 180
TSPDFLYVRS WLPCIFFAGG ITMGNIGRQL AMYECKVIAE KSHQE 225

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologINSIG2100861144G1DGF2Capra hircusPredictionMore>>
1:1 orthologINSIG2100049957F6V608Equus caballusPredictionMore>>
1:1 orthologINSIG2A0A0C4DGZ4Homo sapiensPredictionMore>>
1:1 orthologInsig272999Q91WG1CPOMus musculusPublicationMore>>
1:1 orthologINSIG2743385H2QIL8Pan troglodytesPredictionMore>>
1:1 orthologINSIG2100170127Q6PQZ3Sus scrofaPredictionMore>>
1:1 orthologINSIG2100355934G1SNI6Oryctolagus cuniculusPredictionMore>>
1:1 orthologInsig2288985Q80UA9Rattus norvegicusPredictionMore>>
1:1 orthologinsig2399645Q8AV60Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0008203 cholesterol metabolic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0153 Cholesterol metabolism
KW-0256 Endoplasmic reticulum
KW-0443 Lipid metabolism
KW-0472 Membrane
KW-1185 Reference proteome
KW-0753 Steroid metabolism
KW-1207 Sterol metabolism
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR025929 INSIG_fam

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF07281 INSIG