Gene: INSIG2

Basic information

Tag Content
Uniprot ID H2QIL8; A0A2J8M218;
Entrez ID 743385
Genbank protein ID JAA15385.1; JAA36127.1; JAA29385.1; JAA10524.1;
Genbank nucleotide ID XM_009443168.2; XM_001155360.5;
Ensembl protein ID ENSPTRP00000021225
Ensembl nucleotide ID ENSPTRG00000012395
Gene name Insulin-induced gene protein
Gene symbol INSIG2
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Mediates feedback control of cholesterol synthesis.
Sequence
MAEGETESPG PKKCGPYISS VTSQSVNLMI RGVVLFFIGV FLALVLNLLQ IQRNVTLFPP 60
DVIASIFSSA WWVPPCCGTA SAVIGLLYPC IDRHLGEPHK FKREWSSVMR CVAVFVGINH 120
ASAKVDFDNN IQLSLTLAAL SIGLWWTFDR SRSGFGLGVG IAFLATVVTQ LLVYNGVYQY 180
TSPDFLYVRS WLPCIFFAGG ITMGNIGRQL AMYECKVIAE KSHQE 225

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologINSIG2100861144G1DGF2Capra hircusPredictionMore>>
1:1 orthologINSIG2100049957F6V608Equus caballusPredictionMore>>
1:1 orthologINSIG2A0A0C4DGZ4Homo sapiensPredictionMore>>
1:1 orthologInsig272999Q91WG1CPOMus musculusPublicationMore>>
1:1 orthologINSIG2743385H2QIL8Pan troglodytesPredictionMore>>
1:1 orthologINSIG2100170127Q6PQZ3Sus scrofaPredictionMore>>
1:1 orthologINSIG2100355934G1SNI6Oryctolagus cuniculusPredictionMore>>
1:1 orthologInsig2288985Q80UA9Rattus norvegicusPredictionMore>>
1:1 orthologinsig2399645Q8AV60Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0032937 SREBP-SCAP-Insig complex
GO:0006695 cholesterol biosynthetic process
GO:0060363 cranial suture morphogenesis
GO:0042472 inner ear morphogenesis
GO:0042474 middle ear morphogenesis
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0010894 negative regulation of steroid biosynthetic process
GO:0060021 roof of mouth development
GO:0032933 SREBP signaling pathway
GO:0006641 triglyceride metabolic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0153 Cholesterol metabolism
KW-0256 Endoplasmic reticulum
KW-0443 Lipid metabolism
KW-0472 Membrane
KW-1185 Reference proteome
KW-0753 Steroid metabolism
KW-1207 Sterol metabolism
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR025929 INSIG_fam

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF07281 INSIG