Gene: insig2

Basic information

Tag Content
Uniprot ID Q8AV60
Entrez ID 399645
Genbank protein ID AAN28328.1; AAI62662.1; AAI62666.1;
Genbank nucleotide ID NM_212804.1
Ensembl protein ID ENSDARP00000153121
Ensembl nucleotide ID ENSDARG00000113367
Gene name Insulin-induced gene protein
Gene symbol insig2
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Mediates feedback control of cholesterol synthesis.
Sequence
MSEVSSVSRR GPYVSMITSR SVNLLIRAAM LFTVGVFLAL VLNLLQVQRN VTLFPPDVIS 60
SIFSSAWWVP PCCGTAAALI GLLYPCMDRR LGEPHKLKRE WSNVMRCVAV FVGINHASAK 120
VDFANNVQLS LTLAALSVGL WWTFDRSRSG FGLGVIIAIL ATLATQLLVY NGVFQYTSPD 180
FLYIRSWLPC IFFAGVITVG NIGRQLALYE YKVSQEKSHQ D 221

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologINSIG2100861144G1DGF2Capra hircusPredictionMore>>
1:1 orthologINSIG2100049957F6V608Equus caballusPredictionMore>>
1:1 orthologINSIG2A0A0C4DGZ4Homo sapiensPredictionMore>>
1:1 orthologInsig272999Q91WG1CPOMus musculusPublicationMore>>
1:1 orthologINSIG2743385H2QIL8Pan troglodytesPredictionMore>>
1:1 orthologINSIG2100170127Q6PQZ3Sus scrofaPredictionMore>>
1:1 orthologINSIG2100355934G1SNI6Oryctolagus cuniculusPredictionMore>>
1:1 orthologInsig2288985Q80UA9Rattus norvegicusPredictionMore>>
1:1 orthologinsig2399645Q8AV60Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005783 endoplasmic reticulum
GO:0032937 SREBP-SCAP-Insig complex
GO:0008289 lipid binding
GO:0032869 cellular response to insulin stimulus
GO:0006695 cholesterol biosynthetic process
GO:0032933 SREBP signaling pathway
GO:0036316 SREBP-SCAP complex retention in endoplasmic reticulum
GO:0016126 sterol biosynthetic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0153 Cholesterol metabolism
KW-0256 Endoplasmic reticulum
KW-0443 Lipid metabolism
KW-0446 Lipid-binding
KW-0472 Membrane
KW-1185 Reference proteome
KW-0753 Steroid metabolism
KW-1207 Sterol metabolism
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR025929 INSIG_fam

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF07281 INSIG