| Tag | Content |
|---|---|
| Uniprot ID | Q80UA9 |
| Entrez ID | 288985 |
| Genbank protein ID | AAN78347.1; AAH85682.1; |
| Genbank nucleotide ID | XM_006249667.3; XM_006249668.3; XM_017598687.1; XM_006249669.3; NM_178091.4; |
| Ensembl protein ID | ENSRNOP00000003391 |
| Ensembl nucleotide ID | ENSRNOG00000002478 |
| Gene name | Insulin-induced gene 2 protein |
| Gene symbol | Insig2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR (By similarity). |
| Sequence | MAEGETESPR PKKRGPYISS VTSQSVNVVI RGVVLFFIGV FLALVLNLLQ IQRNVTLFPP 60 DVITSIFSSA WWVPPCCGTA SAVIGLLYPC IDRHLGEPHK FKREWSSVMR CVAVFVGINH 120 ASAKVDFDNN FQFSLTLAAL SVGLWWTFDR SRSGFGLGVG IAFLATVVTQ LLVYNGVYQY 180 TSPDFLYVRS WLPCIFFAGG ITMGNIGRQL AMYECKVIAE KSHQE 225 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | INSIG2 | 100861144 | G1DGF2 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | INSIG2 | 100049957 | F6V608 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | INSIG2 | A0A0C4DGZ4 | Homo sapiens | Prediction | More>> | |||
| 1:1 ortholog | Insig2 | 72999 | Q91WG1 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | INSIG2 | 743385 | H2QIL8 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | INSIG2 | 100170127 | Q6PQZ3 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | INSIG2 | 100355934 | G1SNI6 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Insig2 | 288985 | Q80UA9 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | insig2 | 399645 | Q8AV60 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005783 | endoplasmic reticulum |
| GO:0032937 | SREBP-SCAP-Insig complex |
| GO:0008134 | transcription factor binding |
| GO:0006695 | cholesterol biosynthetic process |
| GO:0008203 | cholesterol metabolic process |
| GO:0060363 | cranial suture morphogenesis |
| GO:0042472 | inner ear morphogenesis |
| GO:0042474 | middle ear morphogenesis |
| GO:0045717 | negative regulation of fatty acid biosynthetic process |
| GO:0010894 | negative regulation of steroid biosynthetic process |
| GO:0070542 | response to fatty acid |
| GO:0032868 | response to insulin |
| GO:0033993 | response to lipid |
| GO:0006991 | response to sterol depletion |
| GO:0060021 | roof of mouth development |
| GO:0032933 | SREBP signaling pathway |
| GO:0016126 | sterol biosynthetic process |
| GO:0006641 | triglyceride metabolic process |
| InterPro ID | InterPro Term |
|---|---|
| IPR025929 | INSIG_fam |
| Pfam ID | Pfam Term |
|---|---|
| PF07281 | INSIG |