Gene: DLX1

Basic information

Tag Content
Uniprot ID G1SK87
Entrez ID 100348143
Genbank protein ID
Genbank nucleotide ID XM_002712289.3
Ensembl protein ID ENSOCUP00000003211
Ensembl nucleotide ID ENSOCUG00000003707
Gene name Distal-less homeobox 1
Gene symbol DLX1
Organism Oryctolagus cuniculus
NCBI taxa ID 9986
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MTMTTMPESL NSPVSGKAVF MEFGPPNQQM SPSPMSHGHY SMHCLHSAGH SQPDGAYSSA 60
SSFSRPLGYP YVNSVSSHAS SPYISSVQSY PGSASLAQSR LEDPGADSEK STVVEGGEVR 120
FNGKGKKIRK PRTIYSSLQL QALNRRFQQT QYLALPERAE LAASLGLTQT QVKIWFQNKR 180
SKFKKLMKQG GAALESSALA NGRALSAGSP PVPPGWNPNS SSGKGSGGSA GSYIPSYTSW 240
YPSAHQEAMQ QPQLM 255

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologDLX1521806A6H733Bos taurusPredictionMore>>
1:1 orthologDLX1E2RFM6Canis lupus familiarisPredictionMore>>
1:1 orthologDLX1102187006A0A452EKR5Capra hircusPredictionMore>>
1:1 orthologDLX1100053103F6QWX6Equus caballusPredictionMore>>
1:1 orthologDLX11745P56177Homo sapiensPublicationMore>>
1:1 orthologDlx113390Q64317CPOMus musculusPublicationMore>>
1:1 orthologDLX1A0A2I3S2E5Pan troglodytesPredictionMore>>
1:1 ortholog100522648A0A4X1V5H4Sus scrofaPredictionMore>>
1:1 orthologDLX1100348143G1SK87Oryctolagus cuniculusPredictionMore>>
1:1 orthologDlx1296500G3V669Rattus norvegicusPredictionMore>>
1:1 orthologdlx1a30568Q98875Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005634 nucleus
GO:0003682 chromatin binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0071773 cellular response to BMP stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0021893 cerebral cortex GABAergic interneuron fate commitment
GO:0048706 embryonic skeletal system development
GO:0021766 hippocampus development
GO:0030514 negative regulation of BMP signaling pathway
GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus
GO:0043524 negative regulation of neuron apoptotic process
GO:0045746 negative regulation of Notch signaling pathway
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0046533 negative regulation of photoreceptor cell differentiation
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0042475 odontogenesis of dentin-containing tooth
GO:1902871 positive regulation of amacrine cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0009954 proximal/distal pattern formation
GO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
GO:0021544 subpallium development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif

PROSITE

PROSITE ID PROSITE Term
PS00027 HOMEOBOX_1
PS50071 HOMEOBOX_2

Pfam

Pfam ID Pfam Term
PF00046 Homeodomain