| Tag | Content |
|---|---|
| Uniprot ID | G1SK87 |
| Entrez ID | 100348143 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_002712289.3 |
| Ensembl protein ID | ENSOCUP00000003211 |
| Ensembl nucleotide ID | ENSOCUG00000003707 |
| Gene name | Distal-less homeobox 1 |
| Gene symbol | DLX1 |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MTMTTMPESL NSPVSGKAVF MEFGPPNQQM SPSPMSHGHY SMHCLHSAGH SQPDGAYSSA 60 SSFSRPLGYP YVNSVSSHAS SPYISSVQSY PGSASLAQSR LEDPGADSEK STVVEGGEVR 120 FNGKGKKIRK PRTIYSSLQL QALNRRFQQT QYLALPERAE LAASLGLTQT QVKIWFQNKR 180 SKFKKLMKQG GAALESSALA NGRALSAGSP PVPPGWNPNS SSGKGSGGSA GSYIPSYTSW 240 YPSAHQEAMQ QPQLM 255 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DLX1 | 521806 | A6H733 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | DLX1 | E2RFM6 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | DLX1 | 102187006 | A0A452EKR5 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | DLX1 | 100053103 | F6QWX6 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | DLX1 | 1745 | P56177 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Dlx1 | 13390 | Q64317 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | DLX1 | A0A2I3S2E5 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | 100522648 | A0A4X1V5H4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | DLX1 | 100348143 | G1SK87 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Dlx1 | 296500 | G3V669 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dlx1a | 30568 | Q98875 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0003682 | chromatin binding |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0071773 | cellular response to BMP stimulus |
| GO:0071560 | cellular response to transforming growth factor beta stimulus |
| GO:0021893 | cerebral cortex GABAergic interneuron fate commitment |
| GO:0048706 | embryonic skeletal system development |
| GO:0021766 | hippocampus development |
| GO:0030514 | negative regulation of BMP signaling pathway |
| GO:1903845 | negative regulation of cellular response to transforming growth factor beta stimulus |
| GO:0043524 | negative regulation of neuron apoptotic process |
| GO:0045746 | negative regulation of Notch signaling pathway |
| GO:0048715 | negative regulation of oligodendrocyte differentiation |
| GO:0046533 | negative regulation of photoreceptor cell differentiation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:1902871 | positive regulation of amacrine cell differentiation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0009954 | proximal/distal pattern formation |
| GO:0021882 | regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment |
| GO:0021544 | subpallium development |
| Pfam ID | Pfam Term |
|---|---|
| PF00046 | Homeodomain |