| Tag | Content |
|---|---|
| Uniprot ID | G1SL02 |
| Entrez ID | 100347007 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_008271129.2; XM_008271131.2; XM_008271130.2; XM_008271132.2; |
| Ensembl protein ID | ENSOCUP00000003523 |
| Ensembl nucleotide ID | ENSOCUG00000004060 |
| Gene name | AP complex subunit beta |
| Gene symbol | AP2B1 |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MTDSKYFTTN KKGEIFELKA ELNNEKKEKR KEAVKKVIAA MTVGKDVSSL FPDVVNCMQT 60 DNLELKKLVY LYLMNYAKSQ PDMAIMAVNS FVKDCEDPNP LIRALAVRTM GCIRVDKITE 120 YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQMVEDQG FLDSLRDLIA DSNPMVVANA 180 VAALSEISES HPNSNLLDLN PQNINKLLTA LNECTEWGQI FILDCLSNYN PKDDREAQSI 240 CERVTPRLSH ANSAVVLSAV KVLMKFLELL PKDSDYYNML LKKLAPPLVT LLSGEPEVQY 300 VALRNINLIV QKRPEILKQE IKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE 360 YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIRDIFRK 420 YPNKYESIIA TLCENLDSLD EPDARAAMIW IVGEYAERID NADELLESFL EGFHDESTQV 480 QLTLLTAIVK LFLKKPSETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVTAKEV 540 VLSEKPLISE ETDLIEPTLL DELICHIGSL ASVYHKPPNA FVEGSHGIHR KHLPIHHGST 600 DAGDSPVGTT TASNLEQPQV IPSQGDLLGD LLNLDLGPPV NVPQVSSMQM GAVDLLGGGL 660 DSLLGSDLGG GIGGSPAVGQ SFIPSSVPAT FAPSPTPAVV SSGLNDLFEL STGIGMAPGG 720 YVAPKAVWLP AVKAKGLEIS GTFTHRQGHI YMEMNFTNKA LQHMTDFAIQ FNKNSFGVIP 780 STPLAIHTPL MPNQSIDVSL PLNTLGPVMK MEPLNNLQVA VKNNIDVFYF SCLIPLNVLF 840 VEDGKMERQV FLATWKDIPN ENELQFQIKE CHLNADTVSS KLQNNNVYTI AKRNVEGQDM 900 LYQSLKLTNG IWILAELRIQ PGNPNYTLSL KCRAPEVSQY IYQVYDSILK N 951 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | AP2B1 | 480605 | E2RIV1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | AP2B1 | A0A452F9H3 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | AP2B1 | 163 | P63010 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ap2b1 | 71770 | Q9DBG3 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | AP2B1 | 454587 | K7CXZ7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | AP2B1 | A0A480V5W1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | AP2B1 | 100347007 | G1SL02 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Ap2b1 | 140670 | P62944 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ap2b1 | E9QC84 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0030122 | AP-2 adaptor complex |
| GO:0098978 | glutamatergic synapse |
| GO:0098794 | postsynapse |
| GO:0030276 | clathrin binding |
| GO:0035904 | aorta development |
| GO:0072583 | clathrin-dependent endocytosis |
| GO:0060976 | coronary vasculature development |
| GO:0006886 | intracellular protein transport |
| GO:0098884 | postsynaptic neurotransmitter receptor internalization |
| GO:0003281 | ventricular septum development |
| InterPro ID | InterPro Term |
|---|---|
| IPR026739 | AP_beta |
| IPR016342 | AP_complex_bsu_1_2_4 |
| IPR011989 | ARM-like |
| IPR016024 | ARM-type_fold |
| IPR000225 | Armadillo |
| IPR015151 | B-adaptin_app_sub_C |
| IPR002553 | Clathrin/coatomer_adapt-like_N |
| IPR008152 | Clathrin_a/b/g-adaptin_app_Ig |
| IPR013041 | Clathrin_app_Ig-like_sf |
| IPR013037 | Clathrin_b-adaptin_app_Ig-like |
| IPR009028 | Coatomer/calthrin_app_sub_C |
| IPR012295 | TBP_dom_sf |