Gene: AP2B1

Basic information

Tag Content
Uniprot ID K7CXZ7; A0A2J8LJD9;
Entrez ID 454587
Genbank protein ID JAA24532.1; JAA18040.1; JAA44684.1;
Genbank nucleotide ID XM_003953061.3
Ensembl protein ID ENSPTRP00000063712
Ensembl nucleotide ID ENSPTRG00000009021
Gene name AP complex subunit beta
Gene symbol AP2B1
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MTDSKYFTTN KKGEIFELKA ELNNEKKEKR KEAVKKVIAA MTVGKDVSSL FPDVVNCMQT 60
DNLELKKLVY LYLMNYAKSQ PDMAIMAVNS FVKDCEDPNP LIRALAVRTM GCIRVDKITE 120
YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQMVEDQG FLDSLRDLIA DSNPMVVANA 180
VAALSEISES HPNSNLLDLN PQNINKLLTA LNECTEWGQI FILDCLSNYN PKDDREAQSI 240
CERVTPRLSH ANSAVVLSAV KVLMKFLELL PKDSDYYNML LKKLAPPLVT LLSGEPEVQY 300
VALRNINLIV QKRPEILKQE IKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE 360
YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIRDIFRK 420
YPNKYESIIA TLCENLDSLD EPDARAAMIW IVGEYAERID NADELLESFL EGFHDESTQV 480
QLTLLTAIVK LFLKKPSETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVTAKEV 540
VLSEKPLISE ETDLIEPTLL DELICHIGSL ASVYHKPPNA FVEGSHGIHR KHLPIHHGST 600
DAGDSPVGTT TATNLEQPQV IPSQGDLLGD LLNLDLGPPV NVPQVSSMQM GAVDLLGGGL 660
DSLVGQSFIP SSVPATFAPS PTPAVVSSGL NDLFELSTGI GMAPGGYVAP KAVWLPAVKA 720
KGLEISGTFT HRQGHIYMEM NFTNKALQHM TDFAIQFNKN SFGVIPSTPL AIHTPLMPNQ 780
SIDVSLPLNT LGPVMKMEPL NNLQVAVKNN IDVFYFSCLI PLNVLFVEDG KMERQVFLAT 840
WKDIPNENEL QFQIKECHLN ADTVSSKLQN NNVYTIAKRN VEGQDMLYQS LKLTNGIWIL 900
AELRIQPGNP NYTLSLKCRA PEVSQYIYQV YDSILKN 937

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologAP2B1480605E2RIV1Canis lupus familiarisPredictionMore>>
1:1 orthologAP2B1A0A452F9H3Capra hircusPredictionMore>>
1:1 orthologAP2B1163P63010Homo sapiensPredictionMore>>
1:1 orthologAp2b171770Q9DBG3CPOE14.5Mus musculusPublicationMore>>
1:1 orthologAP2B1454587K7CXZ7Pan troglodytesPredictionMore>>
1:1 orthologAP2B1A0A480V5W1Sus scrofaPredictionMore>>
1:1 orthologAP2B1100347007G1SL02Oryctolagus cuniculusPredictionMore>>
1:1 orthologAp2b1140670P62944Rattus norvegicusPredictionMore>>
1:1 orthologap2b1E9QC84Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0030131 clathrin adaptor complex
GO:0030276 clathrin binding
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0472 Membrane
KW-0653 Protein transport
KW-1185 Reference proteome
KW-0813 Transport

Interpro

InterPro ID InterPro Term
IPR026739 AP_beta
IPR016342 AP_complex_bsu_1_2_4
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR015151 B-adaptin_app_sub_C
IPR002553 Clathrin/coatomer_adapt-like_N
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR013041 Clathrin_app_Ig-like_sf
IPR013037 Clathrin_b-adaptin_app_Ig-like
IPR009028 Coatomer/calthrin_app_sub_C
IPR012295 TBP_dom_sf

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF01602 Adaptin_N
PF02883 Alpha_adaptinC2
PF09066 B2-adapt-app_C