| Tag | Content |
|---|---|
| Uniprot ID | G1TCM6 |
| Entrez ID | 100350518 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_017348683.1 |
| Ensembl protein ID | ENSOCUP00000014542 |
| Ensembl nucleotide ID | ENSOCUG00000016925 |
| Gene name | Receptor protein serine/threonine kinase |
| Gene symbol | BMPR1A |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MTQLCVHIRL LGAYLFIISR VHGQNLDSML HGTGVKSESD QKKSENGATL APEDTLPFLK 60 CYCSGHCPDD AVNNTCITNG HCFAIIEEDD QGETTLASGC MKYEGSDFQC KDSPKAQLRR 120 TIECCRTHLC NQYLQPTLPP AVVGPFFDGS VRWLVVLVSM AICIVAMIIF SSCFCYKHYC 180 KSMSSRRRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 240 GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300 SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 360 RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDVPLNT RVGTKRYMAP EVLDESLNKN 420 HFQPYIMADI YSFGLIIWEM ARRCVTGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR 480 PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI 532 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | BMPR1A | 404101 | F1MCE7 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | BMPR1A | 489077 | E2QW66 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | BMPR1A | A0A452DLK9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | BMPR1A | F6UG39 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | BMPR1A | 657 | P36894 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Bmpr1a | 12166 | P36895 | CPO,CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | BMPR1A | 450572 | H2Q272 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | BMPR1A | 100350518 | G1TCM6 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Bmpr1a | 81507 | Q78EA7 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005901 | caveola |
| GO:0009897 | external side of plasma membrane |
| GO:0016021 | integral component of membrane |
| GO:0005524 | ATP binding |
| GO:0098821 | BMP receptor activity |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0042803 | protein homodimerization activity |
| GO:0046332 | SMAD binding |
| GO:0003161 | cardiac conduction system development |
| GO:0003215 | cardiac right ventricle morphogenesis |
| GO:0002062 | chondrocyte differentiation |
| GO:0048589 | developmental growth |
| GO:0035912 | dorsal aorta morphogenesis |
| GO:0009950 | dorsal/ventral axis specification |
| GO:0007398 | ectoderm development |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0048568 | embryonic organ development |
| GO:0003272 | endocardial cushion formation |
| GO:1905285 | fibrous ring of heart morphogenesis |
| GO:0060914 | heart formation |
| GO:0035137 | hindlimb morphogenesis |
| GO:0006955 | immune response |
| GO:0001701 | in utero embryonic development |
| GO:0048368 | lateral mesoderm development |
| GO:0030324 | lung development |
| GO:0048382 | mesendoderm development |
| GO:0001707 | mesoderm formation |
| GO:0003183 | mitral valve morphogenesis |
| GO:0001880 | Mullerian duct regression |
| GO:0050768 | negative regulation of neurogenesis |
| GO:0014912 | negative regulation of smooth muscle cell migration |
| GO:0014032 | neural crest cell development |
| GO:0021998 | neural plate mediolateral regionalization |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0003148 | outflow tract septum morphogenesis |
| GO:0048352 | paraxial mesoderm structural organization |
| GO:0061626 | pharyngeal arch artery morphogenesis |
| GO:0021983 | pituitary gland development |
| GO:0030501 | positive regulation of bone mineralization |
| GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| GO:1904414 | positive regulation of cardiac ventricle development |
| GO:0050679 | positive regulation of epithelial cell proliferation |
| GO:0002053 | positive regulation of mesenchymal cell proliferation |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II |
| GO:0060391 | positive regulation of SMAD protein signal transduction |
| GO:1904707 | positive regulation of vascular smooth muscle cell proliferation |
| GO:2000772 | regulation of cellular senescence |
| GO:0048378 | regulation of lateral mesodermal cell fate specification |
| GO:0060021 | roof of mouth development |
| GO:0001756 | somitogenesis |
| GO:0019827 | stem cell population maintenance |
| GO:0003186 | tricuspid valve morphogenesis |
| GO:0003223 | ventricular compact myocardium morphogenesis |
| GO:0003222 | ventricular trabecula myocardium morphogenesis |