| Tag | Content |
|---|---|
| Uniprot ID | H2Q272; A0A2J8KIS3; |
| Entrez ID | 450572 |
| Genbank protein ID | JAA13841.1; JAA04125.1; JAA33704.1; JAA33706.1; JAA33705.1; JAA30854.1; |
| Genbank nucleotide ID | XM_016918799.1; XM_507889.6; XM_016918802.1; XM_016918806.1; XM_016918803.1; XM_016918801.1; XM_016918800.1; XM_016918805.1; XM_016918804.1; |
| Ensembl protein ID | ENSPTRP00000004727 |
| Ensembl nucleotide ID | ENSPTRG00000002706 |
| Gene name | Receptor protein serine/threonine kinase |
| Gene symbol | BMPR1A |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MTQLYIYIRL LGAYLFIISR VQGQNLDSML HGTGMKSDSN QKKSENGVTL APEDTLPFLK 60 CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLASGC MKYEGSDFQC KDSPKAQLRR 120 TIECCRTNLC NQYLQPTLPP VVIGPFFDGS IRWLVLLISM AVCIIAMIIF SSCFCYKHYC 180 KSISSRRRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 240 GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300 SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 360 RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDVPLNT RVGTKRYMAP EVLDESLNKN 420 HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR 480 PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI 532 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | BMPR1A | 404101 | F1MCE7 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | BMPR1A | 489077 | E2QW66 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | BMPR1A | A0A452DLK9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | BMPR1A | F6UG39 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | BMPR1A | 657 | P36894 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Bmpr1a | 12166 | P36895 | CPO,CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | BMPR1A | 450572 | H2Q272 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | BMPR1A | 100350518 | G1TCM6 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Bmpr1a | 81507 | Q78EA7 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005901 | caveola |
| GO:0009897 | external side of plasma membrane |
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0042803 | protein homodimerization activity |
| GO:0004674 | protein serine/threonine kinase activity |
| GO:0046332 | SMAD binding |
| GO:0005025 | transforming growth factor beta receptor activity, type I |
| GO:0030509 | BMP signaling pathway |
| GO:0071363 | cellular response to growth factor stimulus |
| GO:0009953 | dorsal/ventral pattern formation |
| GO:0006955 | immune response |
| GO:0014912 | negative regulation of smooth muscle cell migration |
| GO:0030501 | positive regulation of bone mineralization |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0060391 | positive regulation of SMAD protein signal transduction |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:1904707 | positive regulation of vascular smooth muscle cell proliferation |
| GO:0006468 | protein phosphorylation |