Tag | Content |
---|---|
Uniprot ID | Q78EA7; Q64308; |
Entrez ID | 81507 |
Genbank protein ID | BAA04549.1; AAB33865.1; BAA07275.1; |
Genbank nucleotide ID | XM_017600256.1; NM_030849.1; |
Ensembl protein ID | ENSRNOP00000074885 |
Ensembl nucleotide ID | ENSRNOG00000052469 |
Gene name | Bone morphogenetic protein receptor type-1A |
Gene symbol | Bmpr1a |
Organism | Rattus norvegicus |
NCBI taxa ID | 10116 |
Cleft type | |
Developmental stage | |
Data sources | Homology search |
Reference | |
Functional description | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. |
Sequence | MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDVD QKKPENGVTL APEDTLPFLK 60 CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC MKYEGSDFQC KDSPKAQLRR 120 TIECCRTNLC NQYLQPTLPP VVIGPFFDGS VRWLAVLISM AVCIVAMIVF SSCFCYKHYC 180 KSISSRGRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 240 GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300 SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 360 RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT RVGTRRYMAP EVLDESLSKN 420 HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR 480 PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI 532 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
---|---|---|---|---|---|---|---|---|
1:1 ortholog | BMPR1A | 404101 | F1MCE7 | Bos taurus | Prediction | More>> | ||
1:1 ortholog | BMPR1A | 489077 | E2QW66 | Canis lupus familiaris | Prediction | More>> | ||
1:1 ortholog | BMPR1A | A0A452DLK9 | Capra hircus | Prediction | More>> | |||
1:1 ortholog | BMPR1A | F6UG39 | Equus caballus | Prediction | More>> | |||
1:1 ortholog | BMPR1A | 657 | P36894 | Homo sapiens | Prediction | More>> | ||
1:1 ortholog | Bmpr1a | 12166 | P36895 | CPO,CLP | Mus musculus | Publication | More>> | |
1:1 ortholog | BMPR1A | 450572 | H2Q272 | Pan troglodytes | Prediction | More>> | ||
1:1 ortholog | BMPR1A | 100350518 | G1TCM6 | Oryctolagus cuniculus | Prediction | More>> | ||
1:1 ortholog | Bmpr1a | 81507 | Q78EA7 | Rattus norvegicus | Prediction | More>> |
GO ID | GO Term |
---|---|
GO:0005901 | caveola |
GO:0009986 | cell surface |
GO:0030425 | dendrite |
GO:0009897 | external side of plasma membrane |
GO:0016021 | integral component of membrane |
GO:0043025 | neuronal cell body |
GO:0005886 | plasma membrane |
GO:0043235 | receptor complex |
GO:0005524 | ATP binding |
GO:0098821 | BMP receptor activity |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO:0046872 | metal ion binding |
GO:0042803 | protein homodimerization activity |
GO:0004674 | protein serine/threonine kinase activity |
GO:0046332 | SMAD binding |
GO:0005025 | transforming growth factor beta receptor activity, type I |
GO:0009952 | anterior/posterior pattern specification |
GO:0030509 | BMP signaling pathway |
GO:0003161 | cardiac conduction system development |
GO:0003215 | cardiac right ventricle morphogenesis |
GO:0051216 | cartilage development |
GO:0030154 | cell differentiation |
GO:0071773 | cellular response to BMP stimulus |
GO:0071363 | cellular response to growth factor stimulus |
GO:0002062 | chondrocyte differentiation |
GO:0048589 | developmental growth |
GO:0035912 | dorsal aorta morphogenesis |
GO:0009950 | dorsal/ventral axis specification |
GO:0009953 | dorsal/ventral pattern formation |
GO:0007398 | ectoderm development |
GO:0042733 | embryonic digit morphogenesis |
GO:0048598 | embryonic morphogenesis |
GO:0048568 | embryonic organ development |
GO:0003272 | endocardial cushion formation |
GO:0003203 | endocardial cushion morphogenesis |
GO:0007492 | endoderm development |
GO:1905285 | fibrous ring of heart morphogenesis |
GO:0007507 | heart development |
GO:0060914 | heart formation |
GO:0003007 | heart morphogenesis |
GO:0035137 | hindlimb morphogenesis |
GO:0006955 | immune response |
GO:0001701 | in utero embryonic development |
GO:0048368 | lateral mesoderm development |
GO:0030324 | lung development |
GO:0048382 | mesendoderm development |
GO:0001707 | mesoderm formation |
GO:0003183 | mitral valve morphogenesis |
GO:0001880 | Mullerian duct regression |
GO:0050768 | negative regulation of neurogenesis |
GO:0014912 | negative regulation of smooth muscle cell migration |
GO:0007399 | nervous system development |
GO:0014032 | neural crest cell development |
GO:0021998 | neural plate mediolateral regionalization |
GO:0060896 | neural plate pattern specification |
GO:0042475 | odontogenesis of dentin-containing tooth |
GO:0003151 | outflow tract morphogenesis |
GO:0003148 | outflow tract septum morphogenesis |
GO:0048339 | paraxial mesoderm development |
GO:0048352 | paraxial mesoderm structural organization |
GO:0007389 | pattern specification process |
GO:0061626 | pharyngeal arch artery morphogenesis |
GO:0021983 | pituitary gland development |
GO:0030501 | positive regulation of bone mineralization |
GO:0060045 | positive regulation of cardiac muscle cell proliferation |
GO:1904414 | positive regulation of cardiac ventricle development |
GO:0050679 | positive regulation of epithelial cell proliferation |
GO:0002053 | positive regulation of mesenchymal cell proliferation |
GO:0045669 | positive regulation of osteoblast differentiation |
GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II |
GO:0060391 | positive regulation of SMAD protein signal transduction |
GO:0045944 | positive regulation of transcription by RNA polymerase II |
GO:0045893 | positive regulation of transcription, DNA-templated |
GO:1904707 | positive regulation of vascular smooth muscle cell proliferation |
GO:0006468 | protein phosphorylation |
GO:0060043 | regulation of cardiac muscle cell proliferation |
GO:2000772 | regulation of cellular senescence |
GO:0048378 | regulation of lateral mesodermal cell fate specification |
GO:0060021 | roof of mouth development |
GO:0001756 | somitogenesis |
GO:0019827 | stem cell population maintenance |
GO:0003186 | tricuspid valve morphogenesis |
GO:0003223 | ventricular compact myocardium morphogenesis |
GO:0003222 | ventricular trabecula myocardium morphogenesis |
Keyword ID | Keyword Term |
---|---|
KW-0067 | ATP-binding |
KW-1003 | Cell membrane |
KW-1015 | Disulfide bond |
KW-0325 | Glycoprotein |
KW-0418 | Kinase |
KW-0460 | Magnesium |
KW-0464 | Manganese |
KW-0472 | Membrane |
KW-0479 | Metal-binding |
KW-0547 | Nucleotide-binding |
KW-0675 | Receptor |
KW-1185 | Reference proteome |
KW-0723 | Serine/threonine-protein kinase |
KW-0732 | Signal |
KW-0808 | Transferase |
KW-0812 | Transmembrane |
KW-1133 | Transmembrane helix |