| Tag | Content |
|---|---|
| Uniprot ID | P36895 |
| Entrez ID | 12166 |
| Genbank protein ID | AAH42611.1; AAA21514.1; CAA80678.1; BAA03769.1; |
| Genbank nucleotide ID | XM_006518470.3; XM_017315806.1; NM_009758.4; XM_006518469.3; |
| Ensembl protein ID | ENSMUSP00000035900 |
| Ensembl nucleotide ID | ENSMUSG00000021796 |
| Gene name | Bone morphogenetic protein receptor type-1A |
| Gene symbol | Bmpr1a |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO,CLP |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 22773757; 15716346; 23776616; |
| Functional description | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction (PubMed:24098149). Mediates induction of adipogenesis by GDF6 (PubMed:23527555). |
| Sequence | MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDLD QKKPENGVTL APEDTLPFLK 60 CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC MKYEGSDFQC KDSPKAQLRR 120 TIECCRTNLC NQYLQPTLPP VVIGPFFDGS IRWLVVLISM AVCIVAMIIF SSCFCYKHYC 180 KSISSRGRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 240 GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 300 SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 360 RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT RVGTKRYMAP EVLDESLNKN 420 HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR 480 PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI 532 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | BMPR1A | 404101 | F1MCE7 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | BMPR1A | 489077 | E2QW66 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | BMPR1A | A0A452DLK9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | BMPR1A | F6UG39 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | BMPR1A | 657 | P36894 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Bmpr1a | 12166 | P36895 | CPO,CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | BMPR1A | 450572 | H2Q272 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | BMPR1A | 100350518 | G1TCM6 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Bmpr1a | 81507 | Q78EA7 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IDA |
| GO:0004674 | protein serine/threonine kinase activity | ISO |
| GO:0004674 | protein serine/threonine kinase activity | IBA |
| GO:0005025 | transforming growth factor beta receptor activity, type I | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | ISO |
| GO:0042803 | protein homodimerization activity | ISO |
| GO:0046332 | SMAD binding | ISO |
| GO:0046332 | SMAD binding | IBA |
| GO:0046872 | metal ion binding | IEA |
| GO:0098821 | BMP receptor activity | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001701 | in utero embryonic development | IMP |
| GO:0001707 | mesoderm formation | IMP |
| GO:0001756 | somitogenesis | IMP |
| GO:0001880 | Mullerian duct regression | IMP |
| GO:0002053 | positive regulation of mesenchymal cell proliferation | IMP |
| GO:0002062 | chondrocyte differentiation | IDA |
| GO:0003007 | heart morphogenesis | IMP |
| GO:0003148 | outflow tract septum morphogenesis | IMP |
| GO:0003151 | outflow tract morphogenesis | IMP |
| GO:0003161 | cardiac conduction system development | IMP |
| GO:0003183 | mitral valve morphogenesis | IMP |
| GO:0003186 | tricuspid valve morphogenesis | IMP |
| GO:0003203 | endocardial cushion morphogenesis | IMP |
| GO:0003215 | cardiac right ventricle morphogenesis | IMP |
| GO:0003222 | ventricular trabecula myocardium morphogenesis | IMP |
| GO:0003223 | ventricular compact myocardium morphogenesis | IMP |
| GO:0003272 | endocardial cushion formation | IMP |
| GO:0006468 | protein phosphorylation | ISO |
| GO:0006468 | protein phosphorylation | IBA |
| GO:0006955 | immune response | ISO |
| GO:0007389 | pattern specification process | IMP |
| GO:0007398 | ectoderm development | IMP |
| GO:0007399 | nervous system development | IMP |
| GO:0007492 | endoderm development | IMP |
| GO:0007507 | heart development | IMP |
| GO:0009950 | dorsal/ventral axis specification | IMP |
| GO:0009952 | anterior/posterior pattern specification | IMP |
| GO:0009953 | dorsal/ventral pattern formation | IGI |
| GO:0009953 | dorsal/ventral pattern formation | IBA |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | ISO |
| GO:0014032 | neural crest cell development | IMP |
| GO:0014912 | negative regulation of smooth muscle cell migration | ISO |
| GO:0019827 | stem cell population maintenance | IMP |
| GO:0021983 | pituitary gland development | IMP |
| GO:0021998 | neural plate mediolateral regionalization | IMP |
| GO:0030154 | cell differentiation | IGI |
| GO:0030324 | lung development | IMP |
| GO:0030501 | positive regulation of bone mineralization | ISO |
| GO:0030509 | BMP signaling pathway | ISO |
| GO:0030509 | BMP signaling pathway | IGI |
| GO:0030509 | BMP signaling pathway | IMP |
| GO:0030509 | BMP signaling pathway | IBA |
| GO:0030509 | BMP signaling pathway | IDA |
| GO:0035137 | hindlimb morphogenesis | IMP |
| GO:0035912 | dorsal aorta morphogenesis | IMP |
| GO:0042475 | odontogenesis of dentin-containing tooth | IMP |
| GO:0042733 | embryonic digit morphogenesis | IGI |
| GO:0045669 | positive regulation of osteoblast differentiation | ISO |
| GO:0045893 | positive regulation of transcription, DNA-templated | IDA |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | ISO |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IMP |
| GO:0048339 | paraxial mesoderm development | IGI |
| GO:0048339 | paraxial mesoderm development | IMP |
| GO:0048352 | paraxial mesoderm structural organization | IMP |
| GO:0048368 | lateral mesoderm development | IMP |
| GO:0048378 | regulation of lateral mesodermal cell fate specification | IGI |
| GO:0048382 | mesendoderm development | IMP |
| GO:0048568 | embryonic organ development | IMP |
| GO:0048589 | developmental growth | IMP |
| GO:0048598 | embryonic morphogenesis | IMP |
| GO:0050679 | positive regulation of epithelial cell proliferation | IMP |
| GO:0050768 | negative regulation of neurogenesis | IMP |
| GO:0051216 | cartilage development | IMP |
| GO:0060021 | roof of mouth development | IMP |
| GO:0060043 | regulation of cardiac muscle cell proliferation | IMP |
| GO:0060045 | positive regulation of cardiac muscle cell proliferation | IMP |
| GO:0060391 | positive regulation of SMAD protein signal transduction | ISO |
| GO:0060896 | neural plate pattern specification | IMP |
| GO:0060914 | heart formation | IMP |
| GO:0061312 | BMP signaling pathway involved in heart development | IC |
| GO:0061626 | pharyngeal arch artery morphogenesis | IMP |
| GO:0071363 | cellular response to growth factor stimulus | IBA |
| GO:0071773 | cellular response to BMP stimulus | ISO |
| GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II | IDA |
| GO:1904414 | positive regulation of cardiac ventricle development | IMP |
| GO:1904707 | positive regulation of vascular smooth muscle cell proliferation | ISO |
| GO:1904707 | positive regulation of vascular smooth muscle cell proliferation | IMP |
| GO:1905285 | fibrous ring of heart morphogenesis | IMP |
| GO:2000772 | regulation of cellular senescence | IGI |
| GO:0001936 | regulation of endothelial cell proliferation | IDA |
| GO:0010665 | regulation of cardiac muscle cell apoptotic process | IMP |
| GO:0045601 | regulation of endothelial cell differentiation | IDA |
| GO:1905292 | regulation of neural crest cell differentiation | IMP |
| GO:1905295 | regulation of neural crest cell fate specification | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | IBA |
| GO:0009897 | external side of plasma membrane | ISO |
| GO:0009986 | cell surface | IDA |
| GO:0016021 | integral component of membrane | IEA |
| GO:0030425 | dendrite | ISO |
| GO:0043025 | neuronal cell body | ISO |
| GO:0043235 | receptor complex | IBA |
| GO:0005901 | caveola | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-201451 | Signaling by BMP | IEA |
| R-MMU-9006936 | Signaling by TGF-beta family members | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0418 | Kinase |
| KW-0460 | Magnesium |
| KW-0464 | Manganese |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0723 | Serine/threonine-protein kinase |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |