| Tag | Content |
|---|---|
| Uniprot ID | G3V8D1 |
| Entrez ID | 25483 |
| Genbank protein ID | EDL94072.1 |
| Genbank nucleotide ID | NM_012982.3 |
| Ensembl protein ID | ENSRNOP00000024765 |
| Ensembl nucleotide ID | ENSRNOG00000018355 |
| Gene name | Homeobox protein MSX-2 |
| Gene symbol | Msx2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MASPSKGGDL FSSDEEGPAV LAGPGPGPGG AEGGAEERRV KVSSLPFSVE ALMSDKKPPK 60 ESPAVPPDCA SAGAVLRPLL LPGHGVRDAH SPGPLVKPFE TASVKSENSE DGAPWIQEPG 120 RYSPPPRHMS PTTCTLRKHK TNRKPRTPFT TSQLLALERK FRQKQYLSIA ERAEFSSSLN 180 LTETQVKIWF QNRRAKAKRL QEAELEKLKM AAKPMLPSGF SLPFPINSPL QAASIYSASY 240 PFHRPVLPIP PVGLYATPVG YGMYHLS 267 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MSX2 | 540230 | Q0P5C3 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MSX2 | 403663 | Q9GK08 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MSX2 | 102169797 | A0A452FSV2 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MSX2 | 4488 | P35548 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Msx2 | 17702 | Q03358 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MSX2 | 744194 | K7D1L0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MSX2 | A0A287BCF4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | MSX2 | 100343959 | G1SWN5 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Msx2 | 25483 | G3V8D1 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | msx2a | A0A0J9YJ71 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0016607 | nuclear speck |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0003712 | transcription coregulator activity |
| GO:0008134 | transcription factor binding |
| GO:0090427 | activation of meiosis |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0061312 | BMP signaling pathway involved in heart development |
| GO:0060346 | bone trabecula formation |
| GO:0060444 | branching involved in mammary gland duct morphogenesis |
| GO:0071392 | cellular response to estradiol stimulus |
| GO:0002063 | chondrocyte development |
| GO:0035115 | embryonic forelimb morphogenesis |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0035880 | embryonic nail plate morphogenesis |
| GO:0070166 | enamel mineralization |
| GO:0003416 | endochondral bone growth |
| GO:0003198 | epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO:0060364 | frontal suture morphogenesis |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0032792 | negative regulation of CREB transcription factor activity |
| GO:0045599 | negative regulation of fat cell differentiation |
| GO:0045617 | negative regulation of keratinocyte differentiation |
| GO:2000678 | negative regulation of transcription regulatory region DNA binding |
| GO:0002076 | osteoblast development |
| GO:0003148 | outflow tract septum morphogenesis |
| GO:0030513 | positive regulation of BMP signaling pathway |
| GO:2001055 | positive regulation of mesenchymal cell apoptotic process |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:0051795 | positive regulation of timing of catagen |
| GO:0023019 | signal transduction involved in regulation of gene expression |
| GO:0048863 | stem cell differentiation |
| GO:0035313 | wound healing, spreading of epidermal cells |
| Pfam ID | Pfam Term |
|---|---|
| PF00046 | Homeodomain |