| Tag | Content |
|---|---|
| Uniprot ID | Q9GK08 |
| Entrez ID | 403663 |
| Genbank protein ID | CAC19897.1; CAC37368.1; |
| Genbank nucleotide ID | NM_001003098.2 |
| Ensembl protein ID | ENSCAFP00000041488; ENSCAFP00030003362; ENSCAFP00040030240; |
| Ensembl nucleotide ID | ENSCAFG00040018772; ENSCAFG00000016731; ENSCAFG00030002082; |
| Gene name | Homeobox protein MSX-2 |
| Gene symbol | MSX2 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity). |
| Sequence | MASPSKGSDL FSSDEEGPAA LAGPGPGPGG AEGAAEERRV KVSSLPFSVE ALMSDKKPPK 60 GASPRPADSA SAGAALRPLL LPGHGAREAP SPGPPGKPFE AASVKSESAE DGAAWMQEPG 120 RYSPPPRHMS PTTCTLRKHK TNRKPRTPFT TSQLLALERK FRQKQYLSIA ERAEFSSSLN 180 LTETQVKIWF QNRRAKAKRL QEAELEKLKM AAKPMLPSGF SLPFPINSPL QAASIYGASY 240 PFHRPVLPIP PVGLYATPVG YGMYHLS 267 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MSX2 | 540230 | Q0P5C3 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MSX2 | 403663 | Q9GK08 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MSX2 | 102169797 | A0A452FSV2 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MSX2 | 4488 | P35548 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Msx2 | 17702 | Q03358 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MSX2 | 744194 | K7D1L0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MSX2 | A0A287BCF4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | MSX2 | 100343959 | G1SWN5 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Msx2 | 25483 | G3V8D1 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | msx2a | A0A0J9YJ71 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005829 | cytosol |
| GO:0016607 | nuclear speck |
| GO:0005634 | nucleus |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0003712 | transcription coregulator activity |
| GO:0008134 | transcription factor binding |
| GO:0044212 | transcription regulatory region DNA binding |
| GO:0090427 | activation of meiosis |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0061312 | BMP signaling pathway involved in heart development |
| GO:0060346 | bone trabecula formation |
| GO:0060444 | branching involved in mammary gland duct morphogenesis |
| GO:0071392 | cellular response to estradiol stimulus |
| GO:0002063 | chondrocyte development |
| GO:0035115 | embryonic forelimb morphogenesis |
| GO:0035116 | embryonic hindlimb morphogenesis |
| GO:0048598 | embryonic morphogenesis |
| GO:0035880 | embryonic nail plate morphogenesis |
| GO:0070166 | enamel mineralization |
| GO:0003416 | endochondral bone growth |
| GO:0003198 | epithelial to mesenchymal transition involved in endocardial cushion formation |
| GO:0060364 | frontal suture morphogenesis |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0032792 | negative regulation of CREB transcription factor activity |
| GO:0045599 | negative regulation of fat cell differentiation |
| GO:0045617 | negative regulation of keratinocyte differentiation |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:2000678 | negative regulation of transcription regulatory region DNA binding |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0002076 | osteoblast development |
| GO:0001649 | osteoblast differentiation |
| GO:0003148 | outflow tract septum morphogenesis |
| GO:0030513 | positive regulation of BMP signaling pathway |
| GO:2001055 | positive regulation of mesenchymal cell apoptotic process |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:0051795 | positive regulation of timing of catagen |
| GO:0023019 | signal transduction involved in regulation of gene expression |
| GO:0048863 | stem cell differentiation |
| GO:0035313 | wound healing, spreading of epidermal cells |
| Pfam ID | Pfam Term |
|---|---|
| PF00046 | Homeodomain |