| Tag | Content |
|---|---|
| Uniprot ID | G3V954 |
| Entrez ID | |
| Genbank protein ID | EDM06220.1; EDM06221.1; |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000036154 |
| Ensembl nucleotide ID | ENSRNOG00000021962 |
| Gene name | Frizzled-2 |
| Gene symbol | Fzd2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MRARSALPRS ALPRLLLPLL LLPAAGPAQF HGEKGISIPD HGFCQPISIP LCTDIAYNQT 60 IMPNLLGHTN QEDAGLEVHQ FYPLVKVQCS PELRFFLCSM YAPVCTVLEQ AIPPCRSICE 120 RARQGCEALM NKFGFQWPER LRCEHFPRHG AEQICVGQNH SEDGTPALLT TAPPSGLQPG 180 AGGTPGGPGG GGAPPRYATL EHPFHCPRVL KVPSYLSYKF LGERDCAAPC EPARPDGSMF 240 FSQEETRFAR LWILTWSVLC CASTFFTVTT YLVDMQRFRY PERPIIFLSG CYTMVSVAYI 300 AGFVLQERVV CNERFSEDGY RTVVQGTKKE GCTILFMMLY FFSMASSIWW VILSLTWFLA 360 AGMKWGHEAI EANSQYFHLA AWAVPAVKTI TILAMGQIDG DLLSGVCFVG LNSLDPLRGF 420 VLAPLFVYLF IGTSFLLAGF VSLFRIRTIM KHDGTKTEKL ERLMVRIGVF SVLYTVPATI 480 VIACYFYEQA FREHWERSWV SQHCKSLAIP CPAHYTPRMS PDFTVYMIKY LMTLIVGITS 540 GFWIWSGKTL HSWRKFYTRL TNSRHGETTV |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FZD2 | 2535 | Q14332 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Fzd2 | 57265 | Q9JIP6 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | FZD2 | H2QD74 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Fzd2 | G3V954 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | fzd2 | F1QBI2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:0030165 | PDZ domain binding |
| GO:0042813 | Wnt-activated receptor activity |
| GO:0060070 | canonical Wnt signaling pathway |
| GO:0090103 | cochlea morphogenesis |
| GO:0030855 | epithelial cell differentiation |
| GO:0060022 | hard palate development |
| GO:0060119 | inner ear receptor cell development |
| GO:0003149 | membranous septum morphogenesis |
| GO:0003150 | muscular septum morphogenesis |
| GO:0003151 | outflow tract morphogenesis |
| GO:0090179 | planar cell polarity pathway involved in neural tube closure |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| GO:0045745 | positive regulation of G protein-coupled receptor signaling pathway |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0007608 | sensory perception of smell |