| Tag | Content |
|---|---|
| Uniprot ID | Q9JIP6; Q810M0; Q9JIP5; Q9WUJ2; |
| Entrez ID | 57265 |
| Genbank protein ID | AAD28286.1; AAH49774.2; AAF74056.1; AAH55727.1; AAF74057.1; |
| Genbank nucleotide ID | NM_020510.2 |
| Ensembl protein ID | ENSMUSP00000091463 |
| Ensembl nucleotide ID | ENSMUSG00000050288 |
| Gene name | Frizzled-2 |
| Gene symbol | Fzd2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E14.5 |
| Data sources | Manually collected |
| Reference | 20940229; 23095888; |
| Functional description | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
| Sequence | MRARSALPRS ALPRLLLPLL LLPAAGPAQF HGEKGISIPD HGFCQPISIP LCTDIAYNQT 60 IMPNLLGHTN QEDAGLEVHQ FYPLVKVQCS PELRFFLCSM YAPVCTVLEQ AIPPCRSICE 120 RARQGCEALM NKFGFQWPER LRCEHFPRHG AEQICVGQNH SEDGAPALLT TAPPSGLQPG 180 AGGTPGGPGG GGSPPRYATL EHPFHCPRVL KVPSYLSYKF LGERDCAAPC EPARPDGSMF 240 FSQEETRFAR LWILTWSVLC CASTFFTVTT YLVDMQRFRY PERPIIFLSG CYTMVSVAYI 300 AGFVLQERVV CNERFSEDGY RTVVQGTKKE GCTILFMMLY FFSMASSIWW VILSLTWFLA 360 AGMKWGHEAI EANSQYFHLA AWAVPAVKTI TILAMGQIDG DLLSGVCFVG LNSLDPLRGF 420 VLAPLFVYLF IGTSFLLAGF VSLFRIRTIM KHDGTKTEKL ERLMVRIGVF SVLYTVPATI 480 VIACYFYEQA FREHWERSWV SQHCKSLAIP CPAHYTPRMS PDFTVYMIKY LMTLIVGITS 540 GFWIWSGKTL HSWRKFYTRL TNSRHGETTV |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | FZD2 | 2535 | Q14332 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Fzd2 | 57265 | Q9JIP6 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | FZD2 | H2QD74 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Fzd2 | G3V954 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | fzd2 | F1QBI2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0017147 | Wnt-protein binding | IBA |
| GO:0030165 | PDZ domain binding | ISO |
| GO:0042802 | identical protein binding | ISO |
| GO:0042813 | Wnt-activated receptor activity | ISO |
| GO:0042813 | Wnt-activated receptor activity | IDA |
| GO:0042813 | Wnt-activated receptor activity | IBA |
| GO:0046982 | protein heterodimerization activity | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003149 | membranous septum morphogenesis | IGI |
| GO:0003150 | muscular septum morphogenesis | IGI |
| GO:0003151 | outflow tract morphogenesis | IGI |
| GO:0007199 | G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger | ISO |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration | ISO |
| GO:0007223 | Wnt signaling pathway, calcium modulating pathway | ISO |
| GO:0007267 | cell-cell signaling | IDA |
| GO:0007608 | sensory perception of smell | IMP |
| GO:0030855 | epithelial cell differentiation | IDA |
| GO:0030855 | epithelial cell differentiation | IGI |
| GO:0045745 | positive regulation of G protein-coupled receptor signaling pathway | ISO |
| GO:0045893 | positive regulation of transcription, DNA-templated | ISO |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | ISO |
| GO:0060022 | hard palate development | IGI |
| GO:0060022 | hard palate development | IMP |
| GO:0060070 | canonical Wnt signaling pathway | ISO |
| GO:0060070 | canonical Wnt signaling pathway | IBA |
| GO:0060119 | inner ear receptor cell development | IGI |
| GO:0060412 | ventricular septum morphogenesis | IGI |
| GO:0090103 | cochlea morphogenesis | IGI |
| GO:0090179 | planar cell polarity pathway involved in neural tube closure | IGI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005623 | cell | IEA |
| GO:0005737 | cytoplasm | ISO |
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | IBA |
| GO:0016021 | integral component of membrane | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-195721 | Signaling by WNT | IEA |
| R-MMU-201681 | TCF dependent signaling in response to WNT | IEA |
| R-MMU-3858494 | Beta-catenin independent WNT signaling | IEA |
| R-MMU-4086398 | Ca2+ pathway | IEA |
| R-MMU-4086400 | PCP/CE pathway | IEA |
| R-MMU-4608870 | Asymmetric localization of PCP proteins | IEA |
| R-MMU-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane | IEA |
| R-MMU-5140745 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-1003 | Cell membrane |
| KW-0217 | Developmental protein |
| KW-1015 | Disulfide bond |
| KW-0297 | G-protein coupled receptor |
| KW-0325 | Glycoprotein |
| KW-0472 | Membrane |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0732 | Signal |
| KW-0807 | Transducer |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0832 | Ubl conjugation |
| KW-0879 | Wnt signaling pathway |