| Tag | Content |
|---|---|
| Uniprot ID | H2QEH9; A0A2J8NEI3; |
| Entrez ID | 455407 |
| Genbank protein ID | JAA21811.1; JAA21810.1; |
| Genbank nucleotide ID | XM_009433959.2; XM_016933657.1; XM_001149646.4; XM_016933658.1; |
| Ensembl protein ID | ENSPTRP00000062376 |
| Ensembl nucleotide ID | ENSPTRG00000043695 |
| Gene name | Mothers against decapentaplegic homolog |
| Gene symbol | SMAD2 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK KLKKTGRLDE 60 LEKAITTQNC NTKCVTIPST CSEIWGLSTP NTIDQWDTTG LYSFSEQTRS LDGRLQVSHR 120 KGLPHVIYCR LWRWPDLHSH HELKAIENCE YAFNLKKDEV CVNPYHYQRV ETPVLPPVLV 180 PRHTEILTEL PPLDDYTHSI PENTNFPAGI EPQSNYIPET PPPGYISEDG ETSDQQLNQS 240 MDTGSPAELS PTTLSPVNHS LDLQPVTYSE PAFWCSIAYY ELNQRVGETF HASQPSLTVD 300 GFTDPSNSER FCLGLLSNVN RNATVEMTRR HIGRGVRLYY IGGEVFAECL SDSAIFVQSP 360 NCNQRYGWHP ATVCKIPPGC NLKIFNNQEF AALLAQSVNQ GFEAVYQLTR MCTIRMSFVK 420 GWGAEYRRQT VTSTPCWIEL HLNGPLQWLD KVLTQMGSPS VRCSSMS 467 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SMAD2 | E1BE92 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | SMAD2 | 480144 | A0A5F4DFT1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SMAD2 | 102188455 | A0A452FCX6 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SMAD2 | 4087 | Q15796 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Smad2 | 17126 | Q62432 | E12.0, E12.5, E13.0, E13.5, E14.0, E15.0, E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | SMAD2 | 455407 | H2QEH9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SMAD2 | 100155304 | A0A287AE86 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | SMAD2 | 100359137 | G1T109 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Smad2 | 29357 | O70436 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | smad2 | F1Q5P5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0032444 | activin responsive factor complex |
| GO:0005737 | cytoplasm |
| GO:0071144 | heteromeric SMAD protein complex |
| GO:0000790 | nuclear chromatin |
| GO:0033613 | activating transcription factor binding |
| GO:0003682 | chromatin binding |
| GO:0070410 | co-SMAD binding |
| GO:0097718 | disordered domain specific binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0070411 | I-SMAD binding |
| GO:0019902 | phosphatase binding |
| GO:0070878 | primary miRNA binding |
| GO:0070412 | R-SMAD binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0048156 | tau protein binding |
| GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity |
| GO:0034713 | type I transforming growth factor beta receptor binding |
| GO:0031625 | ubiquitin protein ligase binding |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0045165 | cell fate commitment |
| GO:0007182 | common-partner SMAD protein phosphorylation |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0048617 | embryonic foregut morphogenesis |
| GO:0001706 | endoderm formation |
| GO:0001701 | in utero embryonic development |
| GO:0030073 | insulin secretion |
| GO:0035556 | intracellular signal transduction |
| GO:0030324 | lung development |
| GO:0001707 | mesoderm formation |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0038092 | nodal signaling pathway |
| GO:0035265 | organ growth |
| GO:0031016 | pancreas development |
| GO:0048340 | paraxial mesoderm morphogenesis |
| GO:0060039 | pericardium development |
| GO:0030513 | positive regulation of BMP signaling pathway |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| GO:1900224 | positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry |
| GO:0009791 | post-embryonic development |
| GO:0051098 | regulation of binding |
| GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway |
| GO:0070723 | response to cholesterol |
| GO:0009749 | response to glucose |
| GO:0062009 | secondary palate development |
| GO:0007183 | SMAD protein complex assembly |
| GO:0060395 | SMAD protein signal transduction |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |
| GO:0001657 | ureteric bud development |
| GO:0007352 | zygotic specification of dorsal/ventral axis |