| Tag | Content |
|---|---|
| Uniprot ID | O70436; A0JPM1; |
| Entrez ID | 29357 |
| Genbank protein ID | AAC12780.1; BAA33453.1; AAI27498.1; BAA81909.1; |
| Genbank nucleotide ID | NM_001277450.1; NM_019191.2; |
| Ensembl protein ID | ENSRNOP00000075341; ENSRNOP00000048329; |
| Ensembl nucleotide ID | ENSRNOG00000018140 |
| Gene name | Mothers against decapentaplegic homolog 2 |
| Gene symbol | Smad2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). |
| Sequence | MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK KLKKTGRLDE 60 LEKAITTQNC NTKCVTIPST CSEIWGLSTA NTVDQWDTTG LYSFSEQTRS LDGRLQVSHR 120 KGLPHVIYCR LWRWPDLHSH HELKAIENCE YAFSLKKDEV CVNPYHYQRV ETPVLPPVLV 180 PRHTEILTEL PPLDDYTHSI PENTNFPAGI EPQSNYIPET PPPGYISEDG ETSDQQLNQS 240 MDTGSPAELS PTTLSPVNHS LDLQPVTYSE PAFWCSIAYY ELNQRVGETF HASQPSLTVD 300 GFTDPSNSER FCLGLLSNVN RNATVEMTRR HIGRGVRLYY IGGEVFAECL SDSAIFVQSP 360 NCNQRYGWHP ATVCKIPPGC NLKIFNNQEF AALLAQSVNQ GFEAVYQLTR MCTIRMSFVK 420 GWGAEYRRQT VTSTPCWIEL HLNGPLQWLD KVLTQMGSPS VRCSSMS 467 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SMAD2 | E1BE92 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | SMAD2 | 480144 | A0A5F4DFT1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SMAD2 | 102188455 | A0A452FCX6 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SMAD2 | 4087 | Q15796 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Smad2 | 17126 | Q62432 | E12.0, E12.5, E13.0, E13.5, E14.0, E15.0, E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | SMAD2 | 455407 | H2QEH9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SMAD2 | 100155304 | A0A287AE86 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | SMAD2 | 100359137 | G1T109 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Smad2 | 29357 | O70436 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | smad2 | F1Q5P5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0032444 | activin responsive factor complex |
| GO:0005737 | cytoplasm |
| GO:0071144 | heteromeric SMAD protein complex |
| GO:0000790 | nuclear chromatin |
| GO:0005634 | nucleus |
| GO:0032991 | protein-containing complex |
| GO:0071141 | SMAD protein complex |
| GO:0005667 | transcription factor complex |
| GO:0033613 | activating transcription factor binding |
| GO:0003682 | chromatin binding |
| GO:0070410 | co-SMAD binding |
| GO:0097718 | disordered domain specific binding |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0003690 | double-stranded DNA binding |
| GO:0070411 | I-SMAD binding |
| GO:0046872 | metal ion binding |
| GO:0019902 | phosphatase binding |
| GO:0070878 | primary miRNA binding |
| GO:0042803 | protein homodimerization activity |
| GO:0070412 | R-SMAD binding |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0046332 | SMAD binding |
| GO:0048156 | tau protein binding |
| GO:0008134 | transcription factor binding |
| GO:0005160 | transforming growth factor beta receptor binding |
| GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity |
| GO:0034713 | type I transforming growth factor beta receptor binding |
| GO:0031625 | ubiquitin protein ligase binding |
| GO:0032924 | activin receptor signaling pathway |
| GO:0030325 | adrenal gland development |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0045165 | cell fate commitment |
| GO:0007182 | common-partner SMAD protein phosphorylation |
| GO:0048589 | developmental growth |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0048617 | embryonic foregut morphogenesis |
| GO:0009880 | embryonic pattern specification |
| GO:0007492 | endoderm development |
| GO:0001706 | endoderm formation |
| GO:0007369 | gastrulation |
| GO:0007507 | heart development |
| GO:0001701 | in utero embryonic development |
| GO:0030073 | insulin secretion |
| GO:0035556 | intracellular signal transduction |
| GO:0030324 | lung development |
| GO:0001707 | mesoderm formation |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0010629 | negative regulation of gene expression |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0038092 | nodal signaling pathway |
| GO:0035265 | organ growth |
| GO:0031016 | pancreas development |
| GO:0048340 | paraxial mesoderm morphogenesis |
| GO:0007389 | pattern specification process |
| GO:0060039 | pericardium development |
| GO:0030513 | positive regulation of BMP signaling pathway |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| GO:0010628 | positive regulation of gene expression |
| GO:1900224 | positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0009791 | post-embryonic development |
| GO:0006468 | protein phosphorylation |
| GO:0051098 | regulation of binding |
| GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway |
| GO:0070723 | response to cholesterol |
| GO:0009749 | response to glucose |
| GO:0062009 | secondary palate development |
| GO:0023019 | signal transduction involved in regulation of gene expression |
| GO:0007183 | SMAD protein complex assembly |
| GO:0060395 | SMAD protein signal transduction |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |
| GO:0001657 | ureteric bud development |
| GO:0042060 | wound healing |
| GO:0007352 | zygotic specification of dorsal/ventral axis |