| Tag | Content |
|---|---|
| Uniprot ID | J9P7Q4 |
| Entrez ID | 483628 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005631271.2 |
| Ensembl protein ID | ENSCAFP00000041693 |
| Ensembl nucleotide ID | ENSCAFG00000008977 |
| Gene name | LDL receptor related protein 4 |
| Gene symbol | LRP4 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MARHWEKKKK KKKKAKTDTN KTREEIVAFC PRESGAGRFW AETGQEDFIA PELSKLRTLI 60 CTENGGLASS PECACGRSHF TCAVSALGEC TCIPAQWQCD GDNDCGDHSD EDGCMLPTCS 120 PLDFHCDNGK CIRRSWVCDG DNDCEDDSDE QDCPPRECEE DEFPCQNGYC IRSLWHCDGD 180 NDCGDNSDEQ CDMRKCSDKE FRCSDGSCIA EHWYCDGDTD CKDGSDEESC PSAVPAPPCN 240 LEEFQCAYGR CILDIYHCDG DDDCGDWSDE SDCSSHQPCR SGEFMCDSGL CINAGWRCDG 300 DADCDDQSDE RNCTTSMCTA EQFRCRSGRC VRLSWRCDGE DDCADNSDEE NCENTGSPQC 360 ASDQFLCWNG RCIGQRKLCN GVNDCGDNSD ESPQQNCRPR TGEENCNVNN GGCAQKCQMV 420 RGAVQCTCHT GYRLTEDGHM CQDVNECAEE GYCSQGCTNS EGAFQCWCEA GYELRPDRRS 480 CKALGPEPVL LFANRIDIRQ VLPHRSEYTL LLNNLENAIA LDFHHRRELV FWSDVTLDRI 540 LRANLNGSNV EEVVSTGLES PGGLAVDWVH DKLYWTDSGT SRIEVANLDG AHRKVLLWQN 600 LEKPRAIALH PMEGTIYWTD WGNTPRIEAS SMDGSGRRII ADTHLFWPNG LTIDYAGHRM 660 YWVDAKHHVI ERANLDGSHR KAVISQGLPH PFAITVFEDS LYWTDWHTKS INSANKFTGK 720 NQEIIRNKLH FPMDIHTLHP QRQPAGKNRC GNNNGGCTHL CLPSGQNYTC ACPTGFRKIS 780 SHACAQSLDK FLLFARRMDI RRISFDTEDL SDDVIPLADV RSAVALDWDS RDDHVYWTDV 840 SSDTISRAKW DGTGQEVVVD TSLESPAGLA IDWVTNKLYW TDAGTDRIEV ANTDGSMRTV 900 LIWENLDRPR DIVVEPMGGY MYWTDWGASP KIERAGMDAS SRQVIISSNL TWPNGLAIDY 960 GSQRLYWADA GMKTIEFAGL DGSKRKVLIG SQLPHPFGLT LYGERIYWTD WQTKSIQSAD 1020 RLTGLDRETL QENLENLMDI HVFHRRRPPV STPCARENGG CSHLCLRSPN PSGFSCTCPT 1080 GINLMSDGKT CSPGMNSFLI FARRIDIRMV SLDIPYFADV VVPINITMKN TIAIGVDPQE 1140 GKVYWSDSTL HSISRANLDG SQHEDIITTG LQTTDGLAVD AIGRKVYWTD TGTNRIEVGN 1200 LDGSMRKVLV WENLDSPRAI VLYHEMGFMY WTDWGENAKL ERSGMDGSDR TVLISNNLGW 1260 PNGLTVDKAS SQLLWADAHT ERIEAADLNG GSRHTLVSPV QHPYGLTLLD SYIYWTDWQT 1320 RSIHRADKGT GSNVILVRSN LPGLMDIQAV DRAQPLGFNK CGSRNGGCSH LCLPRPSGFS 1380 CACPTGIQLK GDGKTCDPSP ETYLLFSSRG SIRRISLDTS DHTDVHIPVP ELNNVISLDY 1440 DSVDGKVYYT DVFLDVIRRA DLNGSNMETV IGRGLKTTDG LAVDWVARNL YWTDTGRNTI 1500 EASRLDGSCR KVLINNSLDE PRAIAVFPRK GYLFWTDWGH IAKIERANLD GSERKVLINT 1560 DLGWPNGLTL DYDTRRIYWV DAHLDRIESA DLNGKLRQVL LSHVSHPFAL TQQDRWIYWT 1620 DWQTKSIQRV DKYSGRNKET VLANVEGLMD IIVVSPQRQT GTNACGVNNG GCTHLCFARA 1680 SDFVCACPDE PDGRPCSLVP GVVPPAPKAT SISERSPVLP NTLPTTLHSS TTRTRTSLEE 1740 VEGRCSEKDA QLGLCAHSNE AVPAAPGEGL HVSYVIGGLL SILLILVVIA ALMLYRHKKS 1800 KLTDPGMGNL TYSNPSYRTS TQEVKIEAIP KPAMYNQLCY KKEGGPDHNY TKEKIKIVEG 1860 ICLLSGDDAE WDDLKQLRSS RGGLLRDHVC MKTDTVSIQA SSGSLDDTET EQLLQEEQSE 1920 CSSVHTAATP ERRGSLPDTG WKHERKLSSE SQV 1953 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LRP4 | 483628 | J9P7Q4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | LRP4 | A0A452FZF0 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | LRP4 | 4038 | O75096 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Lrp4 | 228357 | Q8VI56 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | LRP4 | A0A2I3TEP4 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Lrp4 | Q9QYP1 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0016021 | integral component of membrane |
| GO:0031594 | neuromuscular junction |
| GO:0005886 | plasma membrane |
| GO:0005509 | calcium ion binding |
| GO:0042803 | protein homodimerization activity |
| GO:0030971 | receptor tyrosine kinase binding |
| GO:0150094 | amyloid-beta clearance by cellular catabolic process |
| GO:0009953 | dorsal/ventral pattern formation |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0001942 | hair follicle development |
| GO:0001822 | kidney development |
| GO:0050771 | negative regulation of axonogenesis |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0030279 | negative regulation of ossification |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| GO:1901631 | positive regulation of presynaptic membrane organization |
| GO:1904395 | positive regulation of skeletal muscle acetylcholine-gated channel clustering |
| GO:0097104 | postsynaptic membrane assembly |
| GO:0097105 | presynaptic membrane assembly |
| GO:0009954 | proximal/distal pattern formation |
| GO:0071340 | skeletal muscle acetylcholine-gated channel clustering |
| GO:0051124 | synaptic growth at neuromuscular junction |
| GO:0016055 | Wnt signaling pathway |
| InterPro ID | InterPro Term |
|---|---|
| IPR011042 | 6-blade_b-propeller_TolB-like |
| IPR026823 | cEGF |
| IPR001881 | EGF-like_Ca-bd_dom |
| IPR013032 | EGF-like_CS |
| IPR000742 | EGF-like_dom |
| IPR000152 | EGF-type_Asp/Asn_hydroxyl_site |
| IPR018097 | EGF_Ca-bd_CS |
| IPR009030 | Growth_fac_rcpt_cys_sf |
| IPR036055 | LDL_receptor-like_sf |
| IPR023415 | LDLR_class-A_CS |
| IPR000033 | LDLR_classB_rpt |
| IPR002172 | LDrepeatLR_classA_rpt |