| Tag | Content |
|---|---|
| Uniprot ID | Q9QYP1 |
| Entrez ID | |
| Genbank protein ID | BAA88688.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000021353 |
| Ensembl nucleotide ID | ENSRNOG00000015285 |
| Gene name | Low-density lipoprotein receptor-related protein 4 |
| Gene symbol | Lrp4 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Mediates SOST-dependent inhibition of bone formation (By similarity). Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling (By similarity). Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. Plays an essential role in the process of digit differentiation. |
| Sequence | MRRWWGALLL GALLCAHGTA SNLECACGRS HFTCAVSALG ECTCIPAQWQ CDGDNDCGDH 60 SDEDGCTLPT CSPLDFHCDN GKCIRRSWVC DGDNDCEDDS DEQDCPPREC EEDEFPCQNG 120 YCIRSLWHCD GDNDCGDNSD EQCDMRKCSD KEFRCSDGSC IAEHWYCDGD TDCKDGSDEE 180 SCPSAVPSPP CNLEEFQCAY GRCILDIYHC DGDDDCGDWS DESDCSSHQP CRSGEFMCDS 240 GLCVNAGWRC DGDADCDDQS DERNCTTSMC TAEQFRCRSG RCVRLSWRCD GEDDCADNSD 300 EENCENTGSP QCASDQFLCW NGRCIGQRKL CNGVNDCGDN SDESPQQNCR PRTGEENCNV 360 NNGGCAQKCQ MIRGAVQCTC HTGYRLTEDG RTCQDVNECA EEGYCSQGCT NSEGAFQCWC 420 EAGYELRPDR RSCKALGPEP VLLFANRIDI RQVLPHRSEY TLLLNNLENA IALDFHHRRE 480 LVFWSDVTLD RILRANLNGS NVEEVVSTGL ESPGGLAVDW VHDKLYWTDS GTSRIEVANL 540 DGAHRKVLLW QSLEKPRAIA LHPMEGTIYW TDWGNTPRIE ASSMDGSGRR IIADTHLFWP 600 NGLTIDYAGR RMYWVDAKHH VIERANLDGS HRKAVISQGL PHPFAITVFE DSLYWTDWHT 660 KSINSANKFT GKNQEIIRNK LHFPMDIHTL HPQRQPAGKN RCGDNNGGCT HLCLPSGQNY 720 TCACPTGFRK INSHACAQSL DKFLLFARRM DIRRISFDTE DLSDDVIPLA DVRSAVALDW 780 DSRDDHVYWT DVSTDTISRA KWDGTGQKVV VDTSLESPAG LAIDWVTNKL YWTDAGTDRI 840 EVANTDGSMR TVLIWENLDR PRDIVVEPMG GYMYWTDWGA SPKIERAGMD ASNRQVIISS 900 NLTWPNGLAI DYGSQRLYWA DAGMKTIEFA GLDGSKRKVL IGSQLPHPFG LTLYGQRIYW 960 TDWQTKSIQS ADRLTGLDRE TLQENLENLM DIHVFHRQRP PVTTPCAVEN GGCSHLCLRS 1020 PSPSGFSCTC PTGINLLLDG KTCSPGMNSF LIFARRIDVR MVSLDIPYFA DVVVPINMTM 1080 KNTIAIGVDP LEGKVYWSDS TLHRISRASL DGSQHEDIIT TGLQTTDGLA VDAIGRKVYW 1140 TDTGTNRIEV GNLDGSMRKV LVWQNLDSPR AIVLYHEMGF MYWTDWGENA KLERSGMDGS 1200 DRTVLINNNL GWPNGLTVDK TSSQLLWADA HTERIEVADL NGANRHTLVS PVQHPYGLTL 1260 LDSYIYWTDW QTRSIHRADK STGSNVILVR SNLPGLMDIQ AVDRAQPLGF NKCGSRNGGC 1320 SHLCLPRPSG FSCACPTGIQ LKGDGKTCDP SPETYLLFSS RGSIRRISLD TDDHTDVHVP 1380 VPGLNNVISL DYDSVDGKVY YTDVFLDVIR RADLNGSNME TVIGHGLKTT DGLAVDWVAR 1440 NLYWTDTGRN TIEASRLDGS CRKVLINNSL DEPRAIAVFP RKGYLFWTDW GHIAKIERAN 1500 LDGSERKVLI NADLGWPNGL TLDYDTRRIY WVDAHLDRIE SADLNGKLRQ VLVSHVSHPF 1560 ALTQQDRWIY WTDWQTKSIQ RVDKYSGRNK ETVLANVEGL MDIIVVSPQR QTGTNACGVN 1620 NGGCSHLCFA RASDFVCACP DEPDSHPCSL VPGLMPPAPR ATSLNEKSPV LPNTLPTTLH 1680 SSTTRTRTSP EGAEGRCSER DAQLGLCAHS NEAVPAAPGE GLHVSYAVGG LLSVLLILLV 1740 TAALMLYRHR KSKFTDPGMG NLTYSNPSYR TSTQEVKIEA APKPAMYNQL CYKKEGGPDH 1800 SYTKEKIKIV EGIHLLAGHD AEWGDLKQLR SSRGGLLRDH VCMKTDTVSI QASSGSLDDT 1860 ETEQLLQEEQ SECSSVHTAT TPERRGSLPD TGWKHERKLS SESQV 1905 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LRP4 | 483628 | J9P7Q4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | LRP4 | A0A452FZF0 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | LRP4 | 4038 | O75096 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Lrp4 | 228357 | Q8VI56 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | LRP4 | A0A2I3TEP4 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Lrp4 | Q9QYP1 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0030425 | dendrite |
| GO:0016021 | integral component of membrane |
| GO:0031594 | neuromuscular junction |
| GO:0043025 | neuronal cell body |
| GO:0005886 | plasma membrane |
| GO:0044853 | plasma membrane raft |
| GO:0014069 | postsynaptic density |
| GO:0097060 | synaptic membrane |
| GO:0034185 | apolipoprotein binding |
| GO:0005509 | calcium ion binding |
| GO:0042803 | protein homodimerization activity |
| GO:0030971 | receptor tyrosine kinase binding |
| GO:0097110 | scaffold protein binding |
| GO:0150094 | amyloid-beta clearance by cellular catabolic process |
| GO:0048856 | anatomical structure development |
| GO:0048813 | dendrite morphogenesis |
| GO:0009953 | dorsal/ventral pattern formation |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0030326 | embryonic limb morphogenesis |
| GO:0006897 | endocytosis |
| GO:0001942 | hair follicle development |
| GO:0001822 | kidney development |
| GO:0060173 | limb development |
| GO:0050771 | negative regulation of axonogenesis |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:0030279 | negative regulation of ossification |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| GO:1901631 | positive regulation of presynaptic membrane organization |
| GO:1904395 | positive regulation of skeletal muscle acetylcholine-gated channel clustering |
| GO:0097104 | postsynaptic membrane assembly |
| GO:0097105 | presynaptic membrane assembly |
| GO:0008104 | protein localization |
| GO:0009954 | proximal/distal pattern formation |
| GO:0043113 | receptor clustering |
| GO:0001932 | regulation of protein phosphorylation |
| GO:0071340 | skeletal muscle acetylcholine-gated channel clustering |
| GO:0050808 | synapse organization |
| GO:0051124 | synaptic growth at neuromuscular junction |
| GO:0016055 | Wnt signaling pathway |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0106 | Calcium |
| KW-1003 | Cell membrane |
| KW-0217 | Developmental protein |
| KW-0221 | Differentiation |
| KW-1015 | Disulfide bond |
| KW-0245 | EGF-like domain |
| KW-0254 | Endocytosis |
| KW-0325 | Glycoprotein |
| KW-0472 | Membrane |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0879 | Wnt signaling pathway |
| InterPro ID | InterPro Term |
|---|---|
| IPR011042 | 6-blade_b-propeller_TolB-like |
| IPR026823 | cEGF |
| IPR001881 | EGF-like_Ca-bd_dom |
| IPR013032 | EGF-like_CS |
| IPR000742 | EGF-like_dom |
| IPR000152 | EGF-type_Asp/Asn_hydroxyl_site |
| IPR018097 | EGF_Ca-bd_CS |
| IPR009030 | Growth_fac_rcpt_cys_sf |
| IPR036055 | LDL_receptor-like_sf |
| IPR023415 | LDLR_class-A_CS |
| IPR000033 | LDLR_classB_rpt |
| IPR002172 | LDrepeatLR_classA_rpt |