Gene: SNAI1

Basic information

Tag Content
Uniprot ID K7BGT3; A0A2J8MJD7;
Entrez ID 745644
Genbank protein ID JAA26458.1; JAA00529.1; JAA13324.1; JAA34292.1;
Genbank nucleotide ID XM_016938127.1; XM_016938125.1; XM_009437412.2;
Ensembl protein ID ENSPTRP00000066270
Ensembl nucleotide ID ENSPTRG00000050285
Gene name Snail family transcriptional repressor 1
Gene symbol SNAI1
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MPRSFLVRKP SDPNRKPNYS ELQDSNPEFT FQQPYDQAHL LAAIPPPEIL NPTASLPMLI 60
WDSVLAPQAQ PIAWASLRPQ ESPRAAELTS LSDEDSGKGS QPPSPPSPAP SSFSSTSASS 120
LEAEAYAAFP GLGQVPKQLA QLSDAKDLQA RKAFNCKYCN KEYLSLGALK MHIRSHTLPC 180
VCGTCGKAFS RPWLLQGHVR THTGEKPFSC PHCSRAFADR SNLRAHLQTH SDVKKYQCQA 240
CARTFSRMSL LHKHQESGCS GCPR 264

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSNAI1504492E1BMI0Bos taurusPredictionMore>>
1:1 orthologSNAI1102172917A0A452EKN0Capra hircusPredictionMore>>
1:1 orthologSNAI1100071451F6Z6C0Equus caballusPredictionMore>>
1:1 orthologSNAI16615O95863Homo sapiensPredictionMore>>
1:1 orthologSnai120613Q02085CPOE13.5, E14.5, E15.5Mus musculusPublicationMore>>
1:1 orthologSNAI1745644K7BGT3Pan troglodytesPredictionMore>>
1:1 orthologSNAI1A0A287B2D0Sus scrofaPredictionMore>>
1:1 orthologSnai1116490Q6AY35Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005829 cytosol
GO:0005654 nucleoplasm
GO:0005721 pericentric heterochromatin
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0070888 E-box binding
GO:0019900 kinase binding
GO:0060536 cartilage morphogenesis
GO:0016477 cell migration
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0031069 hair follicle morphogenesis
GO:0070828 heterochromatin organization
GO:0060972 left/right pattern formation
GO:0001707 mesoderm formation
GO:0060806 negative regulation of cell differentiation involved in embryonic placenta development
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010957 negative regulation of vitamin D biosynthetic process
GO:0061314 Notch signaling involved in heart development
GO:0001649 osteoblast differentiation
GO:0030335 positive regulation of cell migration
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0045893 positive regulation of transcription, DNA-templated
GO:2000810 regulation of bicellular tight junction assembly
GO:0060021 roof of mouth development
GO:0060707 trophoblast giant cell differentiation

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0479 Metal-binding
KW-1185 Reference proteome
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

PROSITE

PROSITE ID PROSITE Term
PS00028 ZINC_FINGER_C2H2_1
PS50157 ZINC_FINGER_C2H2_2

Pfam

Pfam ID Pfam Term
PF00096 zf-C2H2