CleftGeneDB-Search

Gene: SNAI1

Basic information

Tag	Content
Uniprot ID	O95863; B2R842; Q9P113; Q9UBP7; Q9UHH7;
Entrez ID	6615
Genbank protein ID	AAD52986.1; BAG36039.1; AAD52996.1; CAB52414.1; AAF32527.1; AAD17332.1; AAH12910.1;
Genbank nucleotide ID	NM_005985.3
Ensembl protein ID	ENSP00000244050
Ensembl nucleotide ID	ENSG00000124216
Gene name	Zinc finger protein SNAI1
Gene symbol	SNAI1
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description	Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
Sequence	MPRSFLVRKP SDPNRKPNYS ELQDSNPEFT FQQPYDQAHL LAAIPPPEIL NPTASLPMLI 60 WDSVLAPQAQ PIAWASLRLQ ESPRVAELTS LSDEDSGKGS QPPSPPSPAP SSFSSTSVSS 120 LEAEAYAAFP GLGQVPKQLA QLSEAKDLQA RKAFNCKYCN KEYLSLGALK MHIRSHTLPC 180 VCGTCGKAFS RPWLLQGHVR THTGEKPFSC PHCSRAFADR SNLRAHLQTH SDVKKYQCQA 240 CARTFSRMSL LHKHQESGCS GCPR 264

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

PDB ID
2Y48
3W5K
3ZMT
4QLI
2Y48

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Developmental stage	Species	Evidence	Details
1:1 ortholog	SNAI1	504492	E1BMI0			Bos taurus	Prediction	More>>
1:1 ortholog	SNAI1	102172917	A0A452EKN0			Capra hircus	Prediction	More>>
1:1 ortholog	SNAI1	100071451	F6Z6C0			Equus caballus	Prediction	More>>
1:1 ortholog	SNAI1	6615	O95863			Homo sapiens	Prediction	More>>
1:1 ortholog	Snai1	20613	Q02085	CPO	E13.5, E14.5, E15.5	Mus musculus	Publication	More>>
1:1 ortholog	SNAI1	745644	K7BGT3			Pan troglodytes	Prediction	More>>
1:1 ortholog	SNAI1		A0A287B2D0			Sus scrofa	Prediction	More>>
1:1 ortholog	Snai1	116490	Q6AY35			Rattus norvegicus	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs750105530	p.Pro2Leu	missense variant	-	NC_000020.11:g.49983064C>T	ExAC,gnomAD
rs1306992161	p.Phe5Leu	missense variant	-	NC_000020.11:g.49983072T>C	gnomAD
NCI-TCGA novel	p.Val7Ala	missense variant	-	NC_000020.11:g.49983079T>C	NCI-TCGA
rs747327243	p.Arg8Met	missense variant	-	NC_000020.11:g.49983082G>T	ExAC,gnomAD
rs747327243	p.Arg8Lys	missense variant	-	NC_000020.11:g.49983082G>A	ExAC,gnomAD
rs1293590680	p.Pro10Leu	missense variant	-	NC_000020.11:g.49983088C>T	gnomAD
rs781754058	p.Ser11Cys	missense variant	-	NC_000020.11:g.49983091C>G	ExAC,gnomAD
rs1315590662	p.Ser11Pro	missense variant	-	NC_000020.11:g.49983090T>C	TOPMed
rs781754058	p.Ser11Phe	missense variant	-	NC_000020.11:g.49983091C>T	ExAC,gnomAD
rs773103954	p.Pro13Ser	missense variant	-	NC_000020.11:g.49983096C>T	ExAC,TOPMed,gnomAD
rs763270707	p.Asn14Ser	missense variant	-	NC_000020.11:g.49983100A>G	ExAC,TOPMed,gnomAD
rs1236903654	p.Lys16Arg	missense variant	-	NC_000020.11:g.49983106A>G	gnomAD
rs771097482	p.Asn18Asp	missense variant	-	NC_000020.11:g.49983111A>G	ExAC,gnomAD
rs1166990801	p.Glu21Gly	missense variant	-	NC_000020.11:g.49983121A>G	gnomAD
rs1233970414	p.Glu21Gln	missense variant	-	NC_000020.11:g.49983120G>C	TOPMed,gnomAD
rs1454855390	p.Leu22Gln	missense variant	-	NC_000020.11:g.49983124T>A	TOPMed
rs760434965	p.Asp24Val	missense variant	-	NC_000020.11:g.49983130A>T	ExAC,gnomAD
rs760434965	p.Asp24Ala	missense variant	-	NC_000020.11:g.49983130A>C	ExAC,gnomAD
rs761598892	p.Ser25Cys	missense variant	-	NC_000020.11:g.49983133C>G	ExAC,TOPMed,gnomAD
rs749859499	p.Pro27Ala	missense variant	-	NC_000020.11:g.49983138C>G	ExAC,TOPMed,gnomAD
COSM3547612	p.Phe31Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.49983834C>A	NCI-TCGA Cosmic
rs751241861	p.Gln32His	missense variant	-	NC_000020.11:g.49983837G>T	ExAC,gnomAD
rs754616561	p.Pro34Leu	missense variant	-	NC_000020.11:g.49983842C>T	ExAC,gnomAD
COSM4099316	p.Tyr35Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.49983844T>A	NCI-TCGA Cosmic
rs767925268	p.Tyr35His	missense variant	-	NC_000020.11:g.49983844T>C	ExAC,gnomAD
rs1478192619	p.Ala38Thr	missense variant	-	NC_000020.11:g.49983853G>A	TOPMed,gnomAD
rs1233210777	p.Leu40Gln	missense variant	-	NC_000020.11:g.49983860T>A	TOPMed
rs1400010479	p.Ala42Thr	missense variant	-	NC_000020.11:g.49983865G>A	gnomAD
rs749440261	p.Ala43Asp	missense variant	-	NC_000020.11:g.49983869C>A	ExAC,gnomAD
NCI-TCGA novel	p.Ile44Thr	missense variant	-	NC_000020.11:g.49983872T>C	NCI-TCGA
rs781403027	p.Ile44Val	missense variant	-	NC_000020.11:g.49983871A>G	ExAC,gnomAD
rs778908255	p.Pro45Thr	missense variant	-	NC_000020.11:g.49983874C>A	ExAC,gnomAD
rs1259181798	p.Pro47Leu	missense variant	-	NC_000020.11:g.49983881C>T	TOPMed,gnomAD
rs1259181798	p.Pro47Leu	missense variant	-	NC_000020.11:g.49983881C>T	NCI-TCGA Cosmic
COSM117774	p.Glu48Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.49983885G>C	NCI-TCGA Cosmic
rs772242378	p.Ile49Met	missense variant	-	NC_000020.11:g.49983888C>G	ExAC,gnomAD
NCI-TCGA novel	p.Leu50Phe	missense variant	-	NC_000020.11:g.49983889C>T	NCI-TCGA
rs747873945	p.Ala54Thr	missense variant	-	NC_000020.11:g.49983901G>A	ExAC,gnomAD
rs1027943358	p.Ala54Val	missense variant	-	NC_000020.11:g.49983902C>T	TOPMed
rs137950928	p.Ser55Leu	missense variant	-	NC_000020.11:g.49983905C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1488083794	p.Leu56Met	missense variant	-	NC_000020.11:g.49983907C>A	gnomAD
rs762606596	p.Met58Val	missense variant	-	NC_000020.11:g.49983913A>G	ExAC,TOPMed,gnomAD
rs1461873794	p.Leu59Phe	missense variant	-	NC_000020.11:g.49983916C>T	TOPMed
rs765996675	p.Leu59His	missense variant	-	NC_000020.11:g.49983917T>A	ExAC,gnomAD
rs759288627	p.Ile60Ser	missense variant	-	NC_000020.11:g.49983920T>G	ExAC,gnomAD
NCI-TCGA novel	p.Ser63Phe	missense variant	-	NC_000020.11:g.49983929C>T	NCI-TCGA
COSM724226	p.Ser63Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.49983929C>G	NCI-TCGA Cosmic
rs1375832604	p.Ser63Tyr	missense variant	-	NC_000020.11:g.49983929C>A	TOPMed,gnomAD
COSM724225	p.Val64Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.49983932T>A	NCI-TCGA Cosmic
rs1478997833	p.Val64Leu	missense variant	-	NC_000020.11:g.49983931G>C	gnomAD
rs34261470	p.Ala66Val	missense variant	-	NC_000020.11:g.49983938C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs34261470	p.Ala66Glu	missense variant	-	NC_000020.11:g.49983938C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1417642689	p.Pro67Arg	missense variant	-	NC_000020.11:g.49983941C>G	gnomAD
rs754357479	p.Gln68His	missense variant	-	NC_000020.11:g.49983945A>C	ExAC,TOPMed,gnomAD
rs556428881	p.Gln70Glu	missense variant	-	NC_000020.11:g.49983949C>G	ExAC,gnomAD
rs778997862	p.Gln70Pro	missense variant	-	NC_000020.11:g.49983950A>C	ExAC,TOPMed,gnomAD
rs556428881	p.Gln70Ter	stop gained	-	NC_000020.11:g.49983949C>T	ExAC,gnomAD
rs1213204124	p.Pro71Ser	missense variant	-	NC_000020.11:g.49983952C>T	TOPMed
rs1213204124	p.Pro71Thr	missense variant	-	NC_000020.11:g.49983952C>A	TOPMed
rs1321065670	p.Ile72Val	missense variant	-	NC_000020.11:g.49983955A>G	gnomAD
rs745898044	p.Ala75Val	missense variant	-	NC_000020.11:g.49983965C>T	ExAC,TOPMed,gnomAD
rs745898044	p.Ala75Asp	missense variant	-	NC_000020.11:g.49983965C>A	ExAC,TOPMed,gnomAD
rs780107207	p.Leu77Arg	missense variant	-	NC_000020.11:g.49983971T>G	ExAC,TOPMed,gnomAD
rs748041292	p.Arg78Gln	missense variant	-	NC_000020.11:g.49983974G>A	NCI-TCGA,NCI-TCGA Cosmic
rs748041292	p.Arg78Gln	missense variant	-	NC_000020.11:g.49983974G>A	ExAC,TOPMed,gnomAD
rs893957614	p.Arg78Trp	missense variant	-	NC_000020.11:g.49983973C>T	TOPMed,gnomAD
rs769458952	p.Gln80His	missense variant	-	NC_000020.11:g.49983981G>C	ExAC,gnomAD
rs1351727234	p.Ser82Arg	missense variant	-	NC_000020.11:g.49983987T>A	gnomAD
rs1209298683	p.Pro83Ser	missense variant	-	NC_000020.11:g.49983988C>T	gnomAD
rs1324595808	p.Val85Met	missense variant	-	NC_000020.11:g.49983994G>A	TOPMed
NCI-TCGA novel	p.Ala86Thr	missense variant	-	NC_000020.11:g.49983997G>A	NCI-TCGA
rs773080496	p.Glu87Lys	missense variant	-	NC_000020.11:g.49984000G>A	ExAC,gnomAD
rs749239193	p.Leu88Pro	missense variant	-	NC_000020.11:g.49984004T>C	ExAC,gnomAD
rs139386653	p.Leu88Val	missense variant	-	NC_000020.11:g.49984003C>G	ESP,TOPMed
rs1237513391	p.Ser92Pro	missense variant	-	NC_000020.11:g.49984015T>C	gnomAD
rs1392283997	p.Ser92Ter	stop gained	-	NC_000020.11:g.49984016C>G	TOPMed
rs4647959	p.Asp93Glu	missense variant	-	NC_000020.11:g.49984020T>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1380552928	p.Asp95Asn	missense variant	-	NC_000020.11:g.49984024G>A	gnomAD
rs1160955297	p.Gly99Ala	missense variant	-	NC_000020.11:g.49984037G>C	gnomAD
rs1364159669	p.Gly99Ser	missense variant	-	NC_000020.11:g.49984036G>A	TOPMed
rs1386831120	p.Ser100Phe	missense variant	-	NC_000020.11:g.49984040C>T	TOPMed,gnomAD
rs774995949	p.Pro102Ser	missense variant	-	NC_000020.11:g.49984045C>T	ExAC,TOPMed,gnomAD
rs969500219	p.Pro103His	missense variant	-	NC_000020.11:g.49984049C>A	TOPMed
NCI-TCGA novel	p.Ser104AlaPheSerTerUnkUnkUnk	frameshift	-	NC_000020.11:g.49984045C>-	NCI-TCGA
rs1263892553	p.Pro108Leu	missense variant	-	NC_000020.11:g.49984064C>T	gnomAD
rs1287163992	p.Ala109Ser	missense variant	-	NC_000020.11:g.49984066G>T	TOPMed
rs754163516	p.Pro110Ser	missense variant	-	NC_000020.11:g.49984069C>T	NCI-TCGA
rs754163516	p.Pro110Ser	missense variant	-	NC_000020.11:g.49984069C>T	ExAC,TOPMed,gnomAD
rs762332137	p.Ser111Leu	missense variant	-	NC_000020.11:g.49984073C>T	ExAC,TOPMed,gnomAD
rs774280694	p.Ser114Phe	missense variant	-	NC_000020.11:g.49984082C>T	NCI-TCGA,NCI-TCGA Cosmic
rs774280694	p.Ser114Phe	missense variant	-	NC_000020.11:g.49984082C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ser115Phe	missense variant	-	NC_000020.11:g.49984085C>T	NCI-TCGA
rs4647958	p.Val118Ala	missense variant	-	NC_000020.11:g.49984094T>C	UniProt,dbSNP
VAR_019969	p.Val118Ala	missense variant	-	NC_000020.11:g.49984094T>C	UniProt
rs4647958	p.Val118Ala	missense variant	-	NC_000020.11:g.49984094T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs751740656	p.Val118Phe	missense variant	-	NC_000020.11:g.49984093G>T	ExAC,gnomAD
NCI-TCGA novel	p.Ser119Phe	missense variant	-	NC_000020.11:g.49984097C>T	NCI-TCGA
rs777739502	p.Leu121Ser	missense variant	-	NC_000020.11:g.49984103T>C	ExAC,gnomAD
rs1400238466	p.Glu122Gly	missense variant	-	NC_000020.11:g.49984106A>G	TOPMed,gnomAD
rs1464466429	p.Ala123Ser	missense variant	-	NC_000020.11:g.49984108G>T	TOPMed,gnomAD
rs771035489	p.Glu124Lys	missense variant	-	NC_000020.11:g.49984111G>A	NCI-TCGA
rs771035489	p.Glu124Gln	missense variant	-	NC_000020.11:g.49984111G>C	ExAC,gnomAD
rs771035489	p.Glu124Lys	missense variant	-	NC_000020.11:g.49984111G>A	ExAC,gnomAD
rs745445690	p.Ala125Val	missense variant	-	NC_000020.11:g.49984115C>T	ExAC,TOPMed,gnomAD
rs745445690	p.Ala125Asp	missense variant	-	NC_000020.11:g.49984115C>A	ExAC,TOPMed,gnomAD
rs774999329	p.Tyr126Cys	missense variant	-	NC_000020.11:g.49984118A>G	ExAC,TOPMed,gnomAD
rs370954430	p.Gly131Asp	missense variant	-	NC_000020.11:g.49984133G>A	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Leu132Phe	missense variant	-	NC_000020.11:g.49984137G>T	NCI-TCGA
rs962565711	p.Gly133Arg	missense variant	-	NC_000020.11:g.49984138G>C	gnomAD
rs1482832618	p.Gln134Arg	missense variant	-	NC_000020.11:g.49984142A>G	gnomAD
COSM6093354	p.Gln134Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000020.11:g.49984141C>T	NCI-TCGA Cosmic
COSM6159952	p.Pro136Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.49984148C>T	NCI-TCGA Cosmic
rs1257870837	p.Pro136Ser	missense variant	-	NC_000020.11:g.49984147C>T	gnomAD
rs762132185	p.Lys137Asn	missense variant	-	NC_000020.11:g.49984152G>T	ExAC,TOPMed,gnomAD
rs762132185	p.Lys137Asn	missense variant	-	NC_000020.11:g.49984152G>C	ExAC,TOPMed,gnomAD
rs535949166	p.Lys137Arg	missense variant	-	NC_000020.11:g.49984151A>G	1000Genomes,ExAC,TOPMed,gnomAD
rs765800408	p.Gln138Leu	missense variant	-	NC_000020.11:g.49984154A>T	ExAC,gnomAD
rs765800408	p.Gln138Pro	missense variant	-	NC_000020.11:g.49984154A>C	ExAC,gnomAD
rs1485334243	p.Ala140Val	missense variant	-	NC_000020.11:g.49984160C>T	gnomAD
rs1222675553	p.Ser143Phe	missense variant	-	NC_000020.11:g.49984169C>T	gnomAD
rs1173230568	p.Lys146Arg	missense variant	-	NC_000020.11:g.49984178A>G	gnomAD
rs933859275	p.Asp147Asn	missense variant	-	NC_000020.11:g.49984180G>A	TOPMed
rs1355598832	p.Asp147Gly	missense variant	-	NC_000020.11:g.49984181A>G	gnomAD
NCI-TCGA novel	p.Arg151Gln	missense variant	-	NC_000020.11:g.49984193G>A	NCI-TCGA
rs1270380770	p.Arg151Ter	stop gained	-	NC_000020.11:g.49984192C>T	NCI-TCGA
rs1270380770	p.Arg151Gly	missense variant	-	NC_000020.11:g.49984192C>G	TOPMed,gnomAD
rs1270380770	p.Arg151Ter	stop gained	-	NC_000020.11:g.49984192C>T	TOPMed,gnomAD
rs751615554	p.Ala153Asp	missense variant	-	NC_000020.11:g.49984199C>A	ExAC,TOPMed,gnomAD
rs766370103	p.Ala153Thr	missense variant	-	NC_000020.11:g.49984198G>A	ExAC,TOPMed,gnomAD
rs781536435	p.Asn155Thr	missense variant	-	NC_000020.11:g.49984205A>C	ExAC,gnomAD
rs781536435	p.Asn155Ser	missense variant	-	NC_000020.11:g.49984205A>G	ExAC,gnomAD
rs1340630367	p.Tyr158His	missense variant	-	NC_000020.11:g.49984213T>C	TOPMed
rs772108022	p.Lys161Arg	missense variant	-	NC_000020.11:g.49984223A>G	ExAC,TOPMed,gnomAD
rs757108623	p.Leu164Phe	missense variant	-	NC_000020.11:g.49984231C>T	ExAC,gnomAD
rs772006202	p.Ala168Val	missense variant	-	NC_000020.11:g.49984244C>T	NCI-TCGA
rs772006202	p.Ala168Val	missense variant	-	NC_000020.11:g.49984244C>T	ExAC,gnomAD
rs745798537	p.Ala168Ser	missense variant	-	NC_000020.11:g.49984243G>T	ExAC
rs1199361493	p.Lys170Glu	missense variant	-	NC_000020.11:g.49984249A>G	gnomAD
rs1485795314	p.Met171Val	missense variant	-	NC_000020.11:g.49984252A>G	TOPMed,gnomAD
rs1409266525	p.His172Asp	missense variant	-	NC_000020.11:g.49984255C>G	gnomAD
rs1034650403	p.His172Arg	missense variant	-	NC_000020.11:g.49984256A>G	TOPMed
rs1465121323	p.Arg174Ter	stop gained	-	NC_000020.11:g.49984261C>T	TOPMed
rs1260566958	p.Arg174Gln	missense variant	-	NC_000020.11:g.49984262G>A	gnomAD
rs1260566958	p.Arg174Gln	missense variant	-	NC_000020.11:g.49984262G>A	NCI-TCGA
rs746508066	p.Thr177Met	missense variant	-	NC_000020.11:g.49984271C>T	ExAC,gnomAD
rs1489010712	p.Thr177Pro	missense variant	-	NC_000020.11:g.49984270A>C	gnomAD
rs533811343	p.Pro179His	missense variant	-	NC_000020.11:g.49984277C>A	1000Genomes,ExAC,gnomAD
rs558251214	p.Cys180Ter	stop gained	-	NC_000020.11:g.49984281C>A	1000Genomes,ExAC,TOPMed,gnomAD
rs369673182	p.Val181Leu	missense variant	-	NC_000020.11:g.49984282G>C	ESP,ExAC,TOPMed,gnomAD
rs369673182	p.Val181Ile	missense variant	-	NC_000020.11:g.49984282G>A	ESP,ExAC,TOPMed,gnomAD
rs369673182	p.Val181Ile	missense variant	-	NC_000020.11:g.49984282G>A	NCI-TCGA
rs544515729	p.Gly183Arg	missense variant	-	NC_000020.11:g.49984288G>A	NCI-TCGA
rs544515729	p.Gly183Arg	missense variant	-	NC_000020.11:g.49984288G>A	1000Genomes,ExAC,gnomAD
rs1194895090	p.Cys185Tyr	missense variant	-	NC_000020.11:g.49984295G>A	TOPMed
rs1317927184	p.Gly186Arg	missense variant	-	NC_000020.11:g.49984297G>A	NCI-TCGA
rs1317927184	p.Gly186Arg	missense variant	-	NC_000020.11:g.49984297G>A	TOPMed
COSM1412408	p.Lys187Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.49984300A>G	NCI-TCGA Cosmic
COSM3547614	p.Phe189Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.49984308C>G	NCI-TCGA Cosmic
rs1239126992	p.Val199Phe	missense variant	-	NC_000020.11:g.49984336G>T	gnomAD
COSM1027916	p.Arg200Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.49984340G>A	NCI-TCGA Cosmic
rs1283483177	p.Arg200Trp	missense variant	-	NC_000020.11:g.49984339C>T	gnomAD
rs1215903717	p.Thr203Ser	missense variant	-	NC_000020.11:g.49984349C>G	gnomAD
COSM1565724	p.Glu205Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.49987874G>A	NCI-TCGA Cosmic
rs1283278596	p.Pro207Ser	missense variant	-	NC_000020.11:g.49987880C>T	NCI-TCGA
rs1283278596	p.Pro207Ser	missense variant	-	NC_000020.11:g.49987880C>T	gnomAD
rs775763372	p.Ser209Thr	missense variant	-	NC_000020.11:g.49987886T>A	ExAC,TOPMed,gnomAD
rs865912088	p.Ser209Cys	missense variant	-	NC_000020.11:g.49987887C>G	TOPMed
rs775763372	p.Ser209Pro	missense variant	-	NC_000020.11:g.49987886T>C	ExAC,TOPMed,gnomAD
rs865912088	p.Ser209Phe	missense variant	-	NC_000020.11:g.49987887C>T	TOPMed
COSM1027917	p.His212Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.49987897C>A	NCI-TCGA Cosmic
rs1336111017	p.His212Arg	missense variant	-	NC_000020.11:g.49987896A>G	gnomAD
rs1198641175	p.His212Gln	missense variant	-	NC_000020.11:g.49987897C>G	gnomAD
rs768825298	p.Arg215His	missense variant	-	NC_000020.11:g.49987905G>A	ExAC,gnomAD
rs760808201	p.Arg215Cys	missense variant	-	NC_000020.11:g.49987904C>T	ExAC,TOPMed,gnomAD
rs768825298	p.Arg215His	missense variant	-	NC_000020.11:g.49987905G>A	NCI-TCGA,NCI-TCGA Cosmic
NCI-TCGA novel	p.Ala218Val	missense variant	-	NC_000020.11:g.49987914C>T	NCI-TCGA
rs891291611	p.Ala218Thr	missense variant	-	NC_000020.11:g.49987913G>A	TOPMed
COSM1412410	p.Arg220His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.49987920G>A	NCI-TCGA Cosmic
rs1237145081	p.Arg220Cys	missense variant	-	NC_000020.11:g.49987919C>T	NCI-TCGA Cosmic
rs1237145081	p.Arg220Cys	missense variant	-	NC_000020.11:g.49987919C>T	gnomAD
NCI-TCGA novel	p.Ser221Cys	missense variant	-	NC_000020.11:g.49987923C>G	NCI-TCGA
rs1234024429	p.Arg224Trp	missense variant	-	NC_000020.11:g.49987931C>T	TOPMed,gnomAD
rs1190162275	p.Ala225Thr	missense variant	-	NC_000020.11:g.49987934G>A	gnomAD
rs766201407	p.Ala225Gly	missense variant	-	NC_000020.11:g.49987935C>G	ExAC,gnomAD
rs1477530045	p.Leu227Pro	missense variant	-	NC_000020.11:g.49987941T>C	gnomAD
rs759488579	p.Gln228Arg	missense variant	-	NC_000020.11:g.49987944A>G	ExAC,gnomAD
COSM4818447	p.Ser231Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000020.11:g.49987953C>G	NCI-TCGA Cosmic
rs1410353503	p.Asp232Tyr	missense variant	-	NC_000020.11:g.49987955G>T	gnomAD
NCI-TCGA novel	p.Val233Gly	missense variant	-	NC_000020.11:g.49987959T>G	NCI-TCGA
rs1232707935	p.Gln239Arg	missense variant	-	NC_000020.11:g.49987977A>G	TOPMed
rs377622092	p.Ala240Val	missense variant	-	NC_000020.11:g.49987980C>T	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Cys241Phe	missense variant	-	NC_000020.11:g.49987983G>T	NCI-TCGA
COSM294839	p.Arg243Trp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.49987988C>T	NCI-TCGA Cosmic
rs1216225175	p.Arg243Gln	missense variant	-	NC_000020.11:g.49987989G>A	NCI-TCGA Cosmic
rs1216225175	p.Arg243Gln	missense variant	-	NC_000020.11:g.49987989G>A	gnomAD
rs1342031448	p.Ser246Cys	missense variant	-	NC_000020.11:g.49987998C>G	gnomAD
rs1342031448	p.Ser246Phe	missense variant	-	NC_000020.11:g.49987998C>T	gnomAD
COSM459729	p.Arg247Pro	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.49988001G>C	NCI-TCGA Cosmic
rs753536560	p.Arg247Gln	missense variant	-	NC_000020.11:g.49988001G>A	ExAC,gnomAD
rs1278280804	p.Arg247Ter	stop gained	-	NC_000020.11:g.49988000C>T	gnomAD
rs1213364501	p.Ser249Pro	missense variant	-	NC_000020.11:g.49988006T>C	gnomAD
NCI-TCGA novel	p.Leu250ArgPheSerTerUnkUnk	frameshift	-	NC_000020.11:g.49988010T>-	NCI-TCGA
rs1191549421	p.His252Arg	missense variant	-	NC_000020.11:g.49988016A>G	gnomAD
NCI-TCGA novel	p.His252ThrPheSerTerUnkUnk	frameshift	-	NC_000020.11:g.49988014C>-	NCI-TCGA
rs779357818	p.Gln255Arg	missense variant	-	NC_000020.11:g.49988025A>G	ExAC,TOPMed,gnomAD
rs779357818	p.Gln255Leu	missense variant	-	NC_000020.11:g.49988025A>T	ExAC,TOPMed,gnomAD
rs1171785260	p.Glu256Gln	missense variant	-	NC_000020.11:g.49988027G>C	gnomAD
rs151036730	p.Gly258Ser	missense variant	-	NC_000020.11:g.49988033G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs151036730	p.Gly258Ser	missense variant	-	NC_000020.11:g.49988033G>A	NCI-TCGA
rs1359462524	p.Cys259Gly	missense variant	-	NC_000020.11:g.49988036T>G	gnomAD
COSM1307513	p.Ser260Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000020.11:g.49988040C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Gly261Arg	missense variant	-	NC_000020.11:g.49988042G>A	NCI-TCGA
rs1328717238	p.Cys262Tyr	missense variant	-	NC_000020.11:g.49988046G>A	gnomAD
rs747141400	p.Cys262Arg	missense variant	-	NC_000020.11:g.49988045T>C	ExAC,gnomAD
rs902610951	p.Arg264His	missense variant	-	NC_000020.11:g.49988052G>A	TOPMed
rs140860809	p.Arg264Cys	missense variant	-	NC_000020.11:g.49988051C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs902610951	p.Arg264His	missense variant	-	NC_000020.11:g.49988052G>A	NCI-TCGA Cosmic

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0001080	Achondroplasia	disease	BEFREE
C0002793	Anaplasia	disease	BEFREE
C0005684	Malignant neoplasm of urinary bladder	disease	BEFREE
C0005695	Bladder Neoplasm	group	BEFREE
C0006142	Malignant neoplasm of breast	disease	BEFREE;CTD_human
C0006826	Malignant Neoplasms	group	BEFREE
C0007102	Malignant tumor of colon	disease	BEFREE
C0007115	Malignant neoplasm of thyroid	disease	BEFREE
C0007131	Non-Small Cell Lung Carcinoma	disease	BEFREE
C0007133	Carcinoma, Papillary	disease	BEFREE;LHGDN
C0007134	Renal Cell Carcinoma	disease	BEFREE
C0007137	Squamous cell carcinoma	disease	BEFREE;LHGDN
C0007193	Cardiomyopathy, Dilated	group	MGD
C0007621	Neoplastic Cell Transformation	phenotype	CTD_human
C0008370	Cholestasis	disease	CTD_human
C0009375	Colonic Neoplasms	group	BEFREE;LHGDN
C0009402	Colorectal Carcinoma	disease	BEFREE
C0009404	Colorectal Neoplasms	group	BEFREE;LHGDN
C0010278	Craniosynostosis	disease	BEFREE
C0010606	Adenoid Cystic Carcinoma	disease	BEFREE
C0011881	Diabetic Nephropathy	disease	BEFREE
C0013720	Ehlers-Danlos Syndrome	disease	BEFREE
C0016057	Fibrosarcoma	disease	BEFREE
C0016169	pathologic fistula	phenotype	BEFREE
C0016781	Fuchs Endothelial Dystrophy	disease	BEFREE
C0017638	Glioma	disease	BEFREE
C0019163	Hepatitis B	disease	BEFREE
C0020538	Hypertensive disease	group	BEFREE
C0021051	Immunologic Deficiency Syndromes	group	BEFREE
C0024117	Chronic Obstructive Airway Disease	disease	BEFREE
C0024623	Malignant neoplasm of stomach	disease	BEFREE;CTD_human
C0025149	Medulloblastoma	disease	BEFREE
C0025202	melanoma	disease	BEFREE;LHGDN
C0026640	Mouth Neoplasms	group	LHGDN
C0027626	Neoplasm Invasiveness	phenotype	CTD_human
C0027627	Neoplasm Metastasis	phenotype	BEFREE;CTD_human;LHGDN
C0028754	Obesity	disease	BEFREE
C0029463	Osteosarcoma	disease	BEFREE
C0029925	Ovarian Carcinoma	disease	BEFREE
C0030421	Paraganglioma	disease	BEFREE
C0031511	Pheochromocytoma	disease	BEFREE
C0032584	polyps	phenotype	BEFREE
C0032927	Precancerous Conditions	group	BEFREE
C0038356	Stomach Neoplasms	group	CTD_human
C0039101	synovial sarcoma	disease	LHGDN
C0039538	Teratoma	disease	BEFREE
C0080024	Piebaldism	disease	BEFREE
C0085786	Hamman-Rich syndrome	disease	BEFREE
C0151650	Renal fibrosis	disease	BEFREE
C0152013	Adenocarcinoma of lung (disorder)	disease	BEFREE
C0153452	Malignant neoplasm of gallbladder	disease	BEFREE
C0153633	Malignant neoplasm of brain	disease	BEFREE
C0153676	Secondary malignant neoplasm of lung	disease	BEFREE
C0153690	Secondary malignant neoplasm of bone	disease	BEFREE
C0178874	Tumor Progression	phenotype	BEFREE
C0205697	Carcinoma, Spindle-Cell	disease	BEFREE
C0206659	Embryonal Carcinoma	disease	BEFREE
C0235782	Gallbladder Carcinoma	disease	BEFREE
C0235974	Pancreatic carcinoma	disease	BEFREE
C0238463	Papillary thyroid carcinoma	disease	CTD_human
C0242379	Malignant neoplasm of lung	disease	BEFREE
C0279671	Cervical Squamous Cell Carcinoma	disease	BEFREE
C0346629	Malignant neoplasm of large intestine	disease	BEFREE
C0346647	Malignant neoplasm of pancreas	disease	BEFREE
C0346957	Disseminated Malignant Neoplasm	phenotype	BEFREE
C0376358	Malignant neoplasm of prostate	disease	BEFREE
C0376545	Hematologic Neoplasms	group	BEFREE
C0476089	Endometrial Carcinoma	disease	BEFREE
C0521158	Recurrent tumor	phenotype	BEFREE
C0521607	Peritoneal Fibrosis	disease	BEFREE
C0524620	Metabolic Syndrome X	disease	BEFREE
C0549473	Thyroid carcinoma	disease	BEFREE
C0585442	Osteosarcoma of bone	disease	BEFREE
C0596263	Carcinogenesis	phenotype	BEFREE
C0598935	Tumor Initiation	phenotype	BEFREE
C0600139	Prostate carcinoma	disease	BEFREE
C0677886	Epithelial ovarian cancer	disease	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE;CTD_human
C0684249	Carcinoma of lung	disease	BEFREE
C0686619	Secondary malignant neoplasm of lymph node	disease	BEFREE
C0699790	Colon Carcinoma	disease	BEFREE
C0699791	Stomach Carcinoma	disease	BEFREE
C0699885	Carcinoma of bladder	disease	BEFREE
C0699893	Skin carcinoma	disease	BEFREE
C0740457	Malignant neoplasm of kidney	disease	BEFREE
C0744869	Metastatic hepatocellular carcinoma	disease	BEFREE
C0853879	Invasive carcinoma of breast	disease	BEFREE
C0919267	ovarian neoplasm	disease	BEFREE;LHGDN
C1140680	Malignant neoplasm of ovary	disease	BEFREE
C1176475	Ductal Carcinoma	disease	LHGDN
C1257931	Mammary Neoplasms, Human	group	CTD_human
C1261473	Sarcoma	group	BEFREE
C1302401	Adenoma of large intestine	disease	BEFREE
C1306459	Primary malignant neoplasm	group	BEFREE
C1306460	Primary malignant neoplasm of lung	disease	BEFREE
C1319315	Adenocarcinoma of large intestine	disease	BEFREE
C1368683	Epithelioma	disease	BEFREE
C1378703	Renal carcinoma	disease	BEFREE
C1458155	Mammary Neoplasms	group	BEFREE;CTD_human;LHGDN
C1519346	Skin Carcinogenesis	disease	BEFREE
C1527249	Colorectal Cancer	disease	BEFREE
C1621958	Glioblastoma Multiforme	disease	BEFREE
C1704272	Benign Prostatic Hyperplasia	disease	BEFREE
C1708349	Hereditary Diffuse Gastric Cancer	disease	CTD_human
C1800706	Idiopathic Pulmonary Fibrosis	disease	BEFREE
C1862939	AMYOTROPHIC LATERAL SCLEROSIS 1	disease	CTD_human
C1862941	Amyotrophic Lateral Sclerosis, Sporadic	disease	CTD_human
C2239176	Liver carcinoma	disease	BEFREE
C2700265	Waardenburg Syndrome Type 2	disease	BEFREE
C2936346	22q11 Deletion Syndrome	disease	BEFREE
C2939420	Metastatic Neoplasm	phenotype	BEFREE
C3266262	Multiple Chronic Conditions	disease	BEFREE
C3501843	Non-medullary thyroid carcinoma	disease	CTD_human
C3501844	Familial Nonmedullary Thyroid Cancer	disease	CTD_human
C3887486	Interstitial lung fibrosis	phenotype	BEFREE

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IDA
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA
GO:0005515	protein binding	IPI
GO:0019900	kinase binding	IPI
GO:0046872	metal ion binding	IEA
GO:0070888	E-box binding	IDA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0000122	negative regulation of transcription by RNA polymerase II	ISS
GO:0000122	negative regulation of transcription by RNA polymerase II	IDA
GO:0000122	negative regulation of transcription by RNA polymerase II	IMP
GO:0001649	osteoblast differentiation	IEP
GO:0001707	mesoderm formation	ISS
GO:0001837	epithelial to mesenchymal transition	ISS
GO:0001837	epithelial to mesenchymal transition	IDA
GO:0003180	aortic valve morphogenesis	TAS
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	ISS
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	TAS
GO:0010718	positive regulation of epithelial to mesenchymal transition	ISS
GO:0010718	positive regulation of epithelial to mesenchymal transition	TAS
GO:0010718	positive regulation of epithelial to mesenchymal transition	IMP
GO:0010957	negative regulation of vitamin D biosynthetic process	IDA
GO:0016477	cell migration	IEA
GO:0030335	positive regulation of cell migration	IMP
GO:0031069	hair follicle morphogenesis	IEA
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	IMP
GO:0045893	positive regulation of transcription, DNA-templated	IMP
GO:0060021	roof of mouth development	IEA
GO:0060536	cartilage morphogenesis	IEA
GO:0060707	trophoblast giant cell differentiation	IEA
GO:0060806	negative regulation of cell differentiation involved in embryonic placenta development	IEA
GO:0060972	left/right pattern formation	IEA
GO:0061314	Notch signaling involved in heart development	ISS
GO:0061314	Notch signaling involved in heart development	TAS
GO:0070828	heterochromatin organization	ISS
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP
GO:2000810	regulation of bicellular tight junction assembly	IMP

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005634	nucleus	ISS
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	IDA
GO:0005654	nucleoplasm	TAS
GO:0005721	pericentric heterochromatin	IDA
GO:0005737	cytoplasm	ISS
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	IDA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1257604	PIP3 activates AKT signaling	IEA
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-6807070	PTEN Regulation	IEA
R-HSA-6807070	PTEN Regulation	TAS
R-HSA-8943724	Regulation of PTEN gene transcription	IEA
R-HSA-8943724	Regulation of PTEN gene transcription	TAS
R-HSA-9006925	Intracellular signaling by second messengers	IEA
R-HSA-9006925	Intracellular signaling by second messengers	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C031763	1,3-butadiene	1,3-butadiene results in decreased expression of SNAI1 mRNA	29038090
C532657	1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one	1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one analog inhibits the reaction [Asbestos, Serpentine affects the localization of SNAI1 protein]	26685284
C581572	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in decreased expression of SNAI1 mRNA	25827057
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]	25656647
C525921	2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine	2-(4-(biphenyl-4-sulfonyl)-piperazin-1-yl)-6,7-dipropoxyquinazolin-4-yl-amine results in decreased expression of SNAI1 mRNA	24497940
C121479	2,4-dihydroxybenzophenone	2,4-dihydroxybenzophenone results in increased expression of SNAI1 protein	27145024
C121479	2,4-dihydroxybenzophenone	Fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of SNAI1 protein]	27145024
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]	25118938
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]	25656647
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of SNAI1 protein	23921149; 24122885;
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	SB 216763 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]]	25118938
C028145	2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine	[2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine results in decreased activity of NOTCH1 protein] which affects the expression of SNAI1 protein	20348013
C034017	2-ethylhexanol	2-ethylhexanol results in increased expression of SNAI1 mRNA	31445079
C016392	3,3'-diindolylmethane	3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of SNAI1 protein]	28844962
C016392	3,3'-diindolylmethane	3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of SNAI1 protein]	28844962
C016392	3,3'-diindolylmethane	3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of SNAI1 protein]	28844962
C023035	3,4,5,3',4'-pentachlorobiphenyl	3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SNAI1 mRNA	28284859
C023035	3,4,5,3',4'-pentachlorobiphenyl	Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SNAI1 mRNA]	28284859
C023035	3,4,5,3',4'-pentachlorobiphenyl	AHR mRNA promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SNAI1 mRNA]	28284859
C023035	3,4,5,3',4'-pentachlorobiphenyl	Fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SNAI1 mRNA]	28284859
C023035	3,4,5,3',4'-pentachlorobiphenyl	PKM protein promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SNAI1 mRNA]	28284859
C023035	3,4,5,3',4'-pentachlorobiphenyl	3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SNAI1 mRNA	23196670
C497286	3,4',5-trimethoxystilbene	3,4',5-trimethoxystilbene promotes the reaction [Tamoxifen results in decreased expression of SNAI1 protein]	23921149
C497286	3,4',5-trimethoxystilbene	3,4',5-trimethoxystilbene results in decreased expression of SNAI1 protein	23921149
C497286	3,4',5-trimethoxystilbene	Tamoxifen promotes the reaction [3,4',5-trimethoxystilbene results in decreased expression of SNAI1 protein]	23921149
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SNAI1 mRNA	16788091
C434003	3-(4-methylphenylsulfonyl)-2-propenenitrile	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]	25656647
C494914	3,5,3',4',5'-pentamethoxystilbene	3,5,3',4',5'-pentamethoxystilbene results in decreased expression of SNAI1 protein	23921149
C090937	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Oxygen deficiency results in increased expression of SNAI1 protein]	28574600
C105260	4-tert-octylphenol	4-tert-octylphenol results in increased expression of SNAI1 protein	27145024
C105260	4-tert-octylphenol	Fulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of SNAI1 protein]	27145024
D015127	9,10-Dimethyl-1,2-benzanthracene	9,10-Dimethyl-1,2-benzanthracene results in increased expression of SNAI1 mRNA	29663660
D015127	9,10-Dimethyl-1,2-benzanthracene	9,10-Dimethyl-1,2-benzanthracene results in increased expression of SNAI1 protein	29663660
D000082	Acetaminophen	Acetaminophen affects the expression of SNAI1 mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SNAI1 mRNA]	28284859
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]	17596522
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [benz(a)anthracene results in increased expression of SNAI1 mRNA]	21635667
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased expression of SNAI1 mRNA]	21635667
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of SNAI1 mRNA]	21635667
D000393	Air Pollutants	Air Pollutants results in increased expression of SNAI1 protein	30641074
D000450	Aldosterone	Acetylcysteine inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]	17596522
D000450	Aldosterone	Aldosterone results in increased expression of SNAI1 mRNA	17596522
D000450	Aldosterone	Eplerenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]	17596522
D000450	Aldosterone	Rotenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]	17596522
D000450	Aldosterone	U 0126 inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]	17596522
C526957	alisol B 23-acetate	alisol B 23-acetate inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]	28578904
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of SNAI1 mRNA	21298039
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SNAI1 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of SNAI1 mRNA	24449571
C545357	antroquinonol	antroquinonol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]	25656647
D000077237	Arsenic Trioxide	Arsenic Trioxide results in decreased expression of SNAI1 mRNA	25304214
D000077237	Arsenic Trioxide	Arsenic Trioxide results in decreased expression of SNAI1 protein	24680928; 29409467;
D000077237	Arsenic Trioxide	[Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of SNAI1 mRNA	29274334
D000077237	Arsenic Trioxide	MIR491 affects the reaction [Arsenic Trioxide results in decreased expression of SNAI1 mRNA]	25304214
D000077237	Arsenic Trioxide	MIR491 mRNA affects the reaction [Arsenic Trioxide results in decreased expression of SNAI1 protein]	24680928
D000077237	Arsenic Trioxide	pervanadate inhibits the reaction [Arsenic Trioxide results in decreased expression of SNAI1 protein]	29409467
D017632	Asbestos, Serpentine	1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one analog inhibits the reaction [Asbestos, Serpentine affects the localization of SNAI1 protein]	26685284
D017632	Asbestos, Serpentine	Asbestos, Serpentine affects the localization of SNAI1 protein	26685284
D017632	Asbestos, Serpentine	SB 216763 inhibits the reaction [Asbestos, Serpentine affects the localization of SNAI1 protein]	26685284
C030935	benz(a)anthracene	Acetylcysteine inhibits the reaction [benz(a)anthracene results in increased expression of SNAI1 mRNA]	21635667
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of SNAI1 mRNA	21635667
C030935	benz(a)anthracene	SB 203580 inhibits the reaction [benz(a)anthracene results in increased expression of SNAI1 mRNA]	21635667
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SNAI1 mRNA	30659931
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SNAI1 mRNA	20064835; 22316170; 26238291;
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased mutagenesis of SNAI1 gene	25435355
C022921	benzo(k)fluoranthene	Acetylcysteine inhibits the reaction [benzo(k)fluoranthene results in increased expression of SNAI1 mRNA]	21635667
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of SNAI1 mRNA	21635667
C022921	benzo(k)fluoranthene	SB 203580 inhibits the reaction [benzo(k)fluoranthene results in increased expression of SNAI1 mRNA]	21635667
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of SNAI1 mRNA	30951980
C006780	bisphenol A	3,3'-diindolylmethane inhibits the reaction [bisphenol A results in increased expression of SNAI1 protein]	28844962
C006780	bisphenol A	bisphenol A results in increased expression of SNAI1 mRNA	25690688; 29275510;
C006780	bisphenol A	bisphenol A results in increased expression of SNAI1 protein	25690688; 28844962;
C006780	bisphenol A	Fulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI1 mRNA]	25690688
C006780	bisphenol A	Fulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI1 protein]	25690688; 28844962;
C006780	bisphenol A	bisphenol A results in increased expression of SNAI1 mRNA	27480627; 30951980;
C006780	bisphenol A	bisphenol A results in increased expression of SNAI1 protein	27480627
C006780	bisphenol A	Fulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI1 mRNA]	27480627
C006780	bisphenol A	Fulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI1 protein]	27480627
C006780	bisphenol A	SNAI1 protein promotes the reaction [bisphenol A results in decreased expression of CDH1 protein]	27480627
C006780	bisphenol A	SNAI1 protein promotes the reaction [bisphenol A results in increased expression of VIM protein]	27480627
C006780	bisphenol A	bisphenol A results in increased expression of SNAI1 mRNA	25181051; 29323181; 30816183;
C006780	bisphenol A	bisphenol A results in increased methylation of SNAI1 gene	28505145
C006780	bisphenol A	ESR1 protein promotes the reaction [bisphenol A results in increased expression of SNAI1 mRNA]	27480627
C000611646	bisphenol F	bisphenol F results in increased expression of SNAI1 mRNA	30951980
C018475	butyraldehyde	butyraldehyde results in increased expression of SNAI1 mRNA	26079696
D002104	Cadmium	Cadmium results in increased expression of SNAI1 protein	31437537
D002104	Cadmium	TGIF1 protein affects the reaction [Cadmium results in increased expression of SNAI1 protein]	31437537
D019256	Cadmium Chloride	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]	25118938
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SNAI1 mRNA	30998937
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SNAI1 protein	25118938; 30998937;
D019256	Cadmium Chloride	MIR30E mRNA inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 mRNA]	30998937
D019256	Cadmium Chloride	MIR30E mRNA inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]	30998937
D019256	Cadmium Chloride	NOTCH1 mutant form inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]	25118938
D019256	Cadmium Chloride	SB 216763 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]]	25118938
D019256	Cadmium Chloride	SNAI1 mutant form inhibits the reaction [Cadmium Chloride results in decreased expression of CDH1 protein]	25118938
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of SNAI1 mRNA	25827057
D002331	Carnitine	Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of SNAI1 protein]	28973641
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SNAI1 mRNA	24763279
D000068579	Celecoxib	Celecoxib affects the localization of SNAI1 protein	29932878
D000068579	Celecoxib	Celecoxib inhibits the reaction [SNAI1 protein binds to CDH1 promoter]	29932878
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of SNAI1 mRNA	27481218
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of SNAI1 protein	27481218
D020111	Chlorodiphenyl (54% Chlorine)	MIR30D mRNA inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of SNAI1 mRNA]	27481218
D020111	Chlorodiphenyl (54% Chlorine)	MIR30D mRNA inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of SNAI1 protein]	27481218
D002738	Chloroquine	Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of SNAI1 mRNA]	30053495
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SNAI1 mRNA	20938992
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of SNAI1 mRNA	30690063
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of SNAI1 protein	23518002
C043561	chrysin	chrysin inhibits the reaction [AKT1 protein results in increased expression of SNAI1 protein]	24122885
C043561	chrysin	chrysin results in decreased expression of SNAI1 protein	24122885; 30578657;
D002939	Ciprofloxacin	Ciprofloxacin results in decreased expression of SNAI1 protein	26947806
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of SNAI1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of SNAI1 mRNA	21618587
C018021	cobaltous chloride	cobaltous chloride results in increased expression of and affects the localization of SNAI1 protein	26174737
C018021	cobaltous chloride	cobaltous chloride results in increased expression of SNAI1 protein	29673971
C018021	cobaltous chloride	tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of and affects the localization of SNAI1 protein]	26174737
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of SNAI1 mRNA	24690739
D003300	Copper	Copper results in increased expression of SNAI1 mRNA	30556269
D019327	Copper Sulfate	Copper Sulfate results in increased expression of SNAI1 mRNA	19549813
C030973	cupric oxide	cupric oxide results in increased expression of SNAI1 mRNA	22077320
D003474	Curcumin	Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]	25656647
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of SNAI1 mRNA	27856280
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of SNAI1 protein	27856280
C057862	cyanoginosin LR	SMAD2 protein affects the reaction [cyanoginosin LR results in increased expression of SNAI1 protein]	27856280
D016572	Cyclosporine	Cyclosporine results in increased expression of and results in increased stability of SNAI1 protein	22416070
D016572	Cyclosporine	[GSK3A protein co-treated with GSK3B protein] affects the reaction [Cyclosporine results in increased expression of SNAI1 protein]	22416070
D016572	Cyclosporine	Cyclosporine results in increased expression of SNAI1 protein	22416070
D016572	Cyclosporine	SNAI1 protein affects the reaction [Cyclosporine results in decreased expression of CDH1 protein]	22416070
D015638	Cytochalasin D	Cytochalasin D affects the localization of SNAI1 protein	25756282
D000077209	Decitabine	Decitabine results in increased expression of SNAI1 mRNA	16367923
C107676	deguelin	deguelin inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]	22986522
C107676	deguelin	deguelin results in decreased expression of SNAI1 mRNA	19861542
C107676	deguelin	deguelin results in decreased expression of SNAI1 protein	22986522
C017185	delphinidin	delphinidin results in decreased expression of SNAI1 protein	29451351
D003907	Dexamethasone	Dexamethasone results in decreased expression of SNAI1 mRNA	25047013
C028009	diallyl disulfide	diallyl disulfide results in decreased expression of SNAI1 mRNA	20600798
C028009	diallyl disulfide	diallyl disulfide results in decreased expression of SNAI1 protein	20600798
C042577	diallyl trisulfide	diallyl trisulfide inhibits the reaction [Oxygen deficiency results in increased expression of SNAI1 protein]	28574600
C042577	diallyl trisulfide	diallyl trisulfide results in decreased expression of SNAI1 protein	27566995
C042577	diallyl trisulfide	LDHA protein inhibits the reaction [diallyl trisulfide results in decreased expression of SNAI1 protein]	27566995
D003976	Diazinon	Diazinon results in increased methylation of SNAI1 gene	22964155
D003993	Dibutyl Phthalate	Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of SNAI1 mRNA]	30053495
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of SNAI1 mRNA	21266533; 30053495;
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of SNAI1 protein	30053495
D003993	Dibutyl Phthalate	Sirolimus promotes the reaction [Dibutyl Phthalate results in increased expression of SNAI1 mRNA]	30053495
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of SNAI1 mRNA	28085963
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of SNAI1 mRNA	16541421
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of SNAI1 mRNA	20146380
C051904	dinophysistoxin 1	dinophysistoxin 1 results in increased expression of SNAI1 mRNA	28939011
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of SNAI1 mRNA	24690739
D004317	Doxorubicin	Doxorubicin results in decreased expression of SNAI1 mRNA	29803840
D004317	Doxorubicin	Doxorubicin results in increased expression of SNAI1 mRNA	28318631
D004317	Doxorubicin	Niclosamide inhibits the reaction [Doxorubicin results in increased expression of SNAI1 mRNA]	28318631
D004391	Dust	Dust results in increased expression of SNAI1 protein	30641074
C010945	embelin	embelin results in decreased expression of SNAI1 protein	24694877
D004726	Endosulfan	Endosulfan affects the localization of SNAI1 protein	22677888
D004726	Endosulfan	Endosulfan results in increased expression of SNAI1 mRNA	22677888
D004726	Endosulfan	Endosulfan results in increased expression of SNAI1 mRNA	29391264
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of SNAI1 mRNA	22079256
D000077545	Eplerenone	Eplerenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]	17596522
C015860	ergosta-4,6,8(14),22-tetraen-3-one	ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]	28578904
D000069347	Erlotinib Hydrochloride	[Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in decreased expression of SNAI1 mRNA	29274334
D004958	Estradiol	3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of SNAI1 protein]	28844962
D004958	Estradiol	[Estradiol co-treated with TGFB1 protein] results in increased expression of SNAI1 mRNA	30165855
D004958	Estradiol	Estradiol results in decreased expression of SNAI1 protein	15955695
D004958	Estradiol	Estradiol results in increased expression of SNAI1 mRNA	25690688
D004958	Estradiol	Estradiol results in increased expression of SNAI1 protein	25690688; 27539251; 28844962;
D004958	Estradiol	Fulvestrant inhibits the reaction [Estradiol results in increased expression of SNAI1 mRNA]	25690688
D004958	Estradiol	Fulvestrant inhibits the reaction [Estradiol results in increased expression of SNAI1 protein]	25690688; 27539251; 28844962;
D004958	Estradiol	Estradiol results in increased expression of SNAI1 mRNA	19484750
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of SNAI1 mRNA	17557909
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of SNAI1 mRNA	23129252
C108339	fludioxonil	fludioxonil results in increased expression of SNAI1 protein	27539251
C108339	fludioxonil	Fulvestrant inhibits the reaction [fludioxonil results in increased expression of SNAI1 protein]	27539251
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SNAI1 mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of SNAI1 mRNA	28937961
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [2,4-dihydroxybenzophenone results in increased expression of SNAI1 protein]	27145024
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SNAI1 mRNA]	28284859
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [4-tert-octylphenol results in increased expression of SNAI1 protein]	27145024
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI1 mRNA]	25690688
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI1 protein]	25690688; 28844962;
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [Estradiol results in increased expression of SNAI1 mRNA]	25690688
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [Estradiol results in increased expression of SNAI1 protein]	25690688; 27539251; 28844962;
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [fludioxonil results in increased expression of SNAI1 protein]	27539251
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [nonylphenol results in increased expression of SNAI1 mRNA]	25690688
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [nonylphenol results in increased expression of SNAI1 protein]	25690688
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [Triclosan results in increased expression of SNAI1 protein]	28844962
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI1 mRNA]	27480627
D000077267	Fulvestrant	Fulvestrant inhibits the reaction [bisphenol A results in increased expression of SNAI1 protein]	27480627
C039281	furan	furan results in increased expression of SNAI1 mRNA	27387713
C007845	gingerol	gingerol inhibits the reaction [Glucose results in increased expression of SNAI1 mRNA]	21829520
C097367	ginsenoside Rg3	ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]	24793912
C097367	ginsenoside Rg3	ginsenoside Rg3 analog inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]	24793912
C055124	glaucocalyxin A	glaucocalyxin A inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]	31059706
C055124	glaucocalyxin A	glaucocalyxin A inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]	31059706
C055124	glaucocalyxin A	glaucocalyxin A results in increased expression of SNAI1 mRNA	31059706
C055124	glaucocalyxin A	glaucocalyxin A results in increased expression of SNAI1 protein	31059706
D005947	Glucose	gingerol inhibits the reaction [Glucose results in increased expression of SNAI1 mRNA]	21829520
D005947	Glucose	Glucose results in increased expression of SNAI1 mRNA	21829520
D005947	Glucose	MAPK14 protein promotes the reaction [Glucose results in increased expression of SNAI1 mRNA]	21829520
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SNAI1 mRNA	24763279
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of SNAI1 protein	22580338
C492448	ICG 001	ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]	28578904
C492448	ICG 001	Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]	28578904
C492448	ICG 001	ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]	28578904
C041508	indeno(1,2,3-cd)pyrene	Acetylcysteine inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of SNAI1 mRNA]	21635667
C041508	indeno(1,2,3-cd)pyrene	indeno(1,2,3-cd)pyrene results in increased expression of SNAI1 mRNA	21635667
C041508	indeno(1,2,3-cd)pyrene	SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of SNAI1 mRNA]	21635667
D007220	Industrial Waste	Industrial Waste results in increased expression of SNAI1 protein	30641074
C057531	jasplakinolide	jasplakinolide inhibits the reaction [AHNAK protein affects the localization of SNAI1 protein]	20388789
C057531	jasplakinolide	jasplakinolide inhibits the reaction [EIF4E protein affects the localization of SNAI1 protein]	20388789
C057531	jasplakinolide	jasplakinolide inhibits the reaction [S100A1 protein affects the localization of SNAI1 protein]	20388789
C057531	jasplakinolide	jasplakinolide inhibits the reaction [SEPTIN9 protein affects the localization of SNAI1 protein]	20388789
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of SNAI1 mRNA	27392435
D019344	Lactic Acid	Lactic Acid results in increased expression of SNAI1 mRNA	30851411
D000077341	Lapatinib	[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of SNAI1 protein	26643609
D000077341	Lapatinib	Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of SNAI1 protein]	26643609
D000077341	Lapatinib	SNAI1 protein results in decreased susceptibility to Lapatinib	26643609
D000077339	Leflunomide	Leflunomide results in increased expression of SNAI1 mRNA	28988120
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SNAI1 protein	22344225
D018021	Lithium Chloride	Lithium Chloride results in decreased degradation of SNAI1 protein	20348013
D018021	Lithium Chloride	[Lithium Chloride results in decreased degradation of SNAI1 protein] which affects the expression of CDH1 protein	20348013
D018021	Lithium Chloride	[Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein] which results in decreased expression of SNAI1 protein	19440036
D019808	Losartan	ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]	28578904
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]	28578904
D019808	Losartan	Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]	28578904
C010389	Lugol's solution	Lugol's solution inhibits the reaction [potassium perchlorate results in increased expression of SNAI1 protein]	29673971
C530108	LY2109761	LY2109761 inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]	25884904
C530108	LY2109761	LY2109761 inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]	25884904
C013592	mangiferin	mangiferin results in decreased expression of SNAI1 protein	23707762
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SNAI1 mRNA	20938992
D008770	Methylnitrosourea	[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI1 mRNA	25164625
D008770	Methylnitrosourea	Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI1 mRNA]	25164625
C548887	MK 2206	MK 2206 results in decreased expression of SNAI1 mRNA	30723155
C548887	MK 2206	[U 0126 co-treated with MK 2206] results in decreased expression of SNAI1 mRNA	30723155
C000622638	MLN7243	MLN7243 results in increased sumoylation of SNAI1 protein	31285264
C406082	monomethylarsonous acid	monomethylarsonous acid results in decreased expression of SNAI1 mRNA	25145660
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in increased expression of SNAI1 mRNA	25554681
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in increased expression of SNAI1 mRNA	25554681
C005273	naringenin	naringenin results in decreased expression of SNAI1 protein	30431227
C022838	nickel chloride	nickel chloride promotes the reaction [SNAI1 protein binds to CDH1 promoter]	22648416
C022838	nickel chloride	nickel chloride results in increased expression of SNAI1 protein	22648416
C029938	nickel sulfate	nickel sulfate results in increased expression of SNAI1 mRNA	20146380
D009534	Niclosamide	Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of SNAI1 protein]	26643609
D009534	Niclosamide	Niclosamide inhibits the reaction [Doxorubicin results in increased expression of SNAI1 mRNA]	28318631
D009534	Niclosamide	Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]	28318631
D009538	Nicotine	Nicotine results in increased expression of SNAI1 mRNA	23219715
D009538	Nicotine	Nicotine results in increased expression of SNAI1 protein	23219715
D009538	Nicotine	SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of BMI1 mRNA]	23219715
D009538	Nicotine	SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of NANOG mRNA]	23219715
D009538	Nicotine	SNAI1 mutant form inhibits the reaction [Nicotine results in increased expression of POU5F1 mRNA]	23219715
D009538	Nicotine	SNAI1 results in increased susceptibility to Nicotine	23219715
C000623013	NMS-873	NMS-873 results in decreased expression of SNAI1 protein	29693262
C025256	nonylphenol	Fulvestrant inhibits the reaction [nonylphenol results in increased expression of SNAI1 mRNA]	25690688
C025256	nonylphenol	Fulvestrant inhibits the reaction [nonylphenol results in increased expression of SNAI1 protein]	25690688
C025256	nonylphenol	nonylphenol results in increased expression of SNAI1 mRNA	25690688
C025256	nonylphenol	nonylphenol results in increased expression of SNAI1 protein	25690688
C011959	oridonin	oridonin inhibits the reaction [TGFB1 protein results in decreased expression of SNAI1 mRNA]	30243739
C011959	oridonin	oridonin inhibits the reaction [TGFB1 protein results in decreased expression of SNAI1 protein]	30243739
C011959	oridonin	oridonin results in decreased expression of SNAI1 mRNA	30243739
C011959	oridonin	oridonin results in decreased expression of SNAI1 protein	30243739
D000077150	Oxaliplatin	[Oxaliplatin co-treated with Topotecan] results in increased expression of SNAI1 mRNA	25729387
D000077150	Oxaliplatin	Oxaliplatin results in increased expression of SNAI1 mRNA	25729387
D010100	Oxygen	3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Oxygen deficiency results in increased expression of SNAI1 protein]	28574600
D010100	Oxygen	diallyl trisulfide inhibits the reaction [Oxygen deficiency results in increased expression of SNAI1 protein]	28574600
D010100	Oxygen	HIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of SNAI1 protein]	22340517
D010100	Oxygen	Oxygen deficiency results in increased expression of SNAI1 protein	22340517; 28574600;
C102487	pachymic acid	pachymic acid analog inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]	28578904
D010269	Paraquat	NFE2L2 protein promotes the reaction [Sirolimus inhibits the reaction [Paraquat results in increased expression of SNAI1 protein]]	28624451
D010269	Paraquat	Paraquat results in increased expression of SNAI1 mRNA	28624451
D010269	Paraquat	Paraquat results in increased expression of SNAI1 protein	28624451
D010269	Paraquat	Sirolimus inhibits the reaction [Paraquat results in increased expression of SNAI1 mRNA]	28624451
D010269	Paraquat	Sirolimus inhibits the reaction [Paraquat results in increased expression of SNAI1 protein]	28624451
D010269	Paraquat	sulforafan inhibits the reaction [Paraquat results in increased expression of SNAI1 protein]	28624451
D052638	Particulate Matter	Particulate Matter results in increased expression of SNAI1 mRNA	28846189
D052638	Particulate Matter	Particulate Matter results in increased expression of SNAI1 protein	28846189
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of SNAI1 mRNA	18593933
C076994	perfluorooctane sulfonic acid	Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of SNAI1 protein]	28973641
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of SNAI1 mRNA	28973641
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of SNAI1 protein	28973641
C076715	pervanadate	pervanadate inhibits the reaction [Arsenic Trioxide results in decreased expression of SNAI1 protein]	29409467
C121565	pifithrin	pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SNAI1 mRNA]	20064835
C006253	pirinixic acid	pirinixic acid results in decreased expression of SNAI1 mRNA	20813756
D010938	Plant Oils	Plant Oils results in increased expression of SNAI1 mRNA	23370395
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in increased expression of SNAI1 mRNA	31348943
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of SNAI1 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of SNAI1 mRNA	22714537
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of SNAI1 mRNA	22079256
C009006	potassium perchlorate	Lugol's solution inhibits the reaction [potassium perchlorate results in increased expression of SNAI1 protein]	29673971
C009006	potassium perchlorate	potassium perchlorate results in increased expression of SNAI1 protein	29673971
C045950	propiconazole	propiconazole results in increased expression of SNAI1 mRNA	30293151
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of SNAI1 mRNA	24780913
C107773	pterostilbene	pterostilbene results in decreased expression of SNAI1 protein	23921149
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of SNAI1 protein]	27060453
C528580	qishen yiqi	qishen yiqi inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]	27636716
C528580	qishen yiqi	qishen yiqi inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]	27636716
D011794	Quercetin	Quercetin results in increased expression of SNAI1 mRNA	21632981
D011794	Quercetin	Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI1 mRNA]	25164625
D000077185	Resveratrol	Resveratrol inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]	23146760; 25884904;
D000077185	Resveratrol	Resveratrol inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]	23146760; 25884904;
D000077185	Resveratrol	Resveratrol results in decreased expression of SNAI1 mRNA	21304978
D000077185	Resveratrol	Resveratrol results in decreased expression of SNAI1 protein	23921149
D000077185	Resveratrol	Resveratrol inhibits the reaction [EGF protein results in increased expression of SNAI1 mRNA]	21794976
C009166	retinol acetate	retinol acetate results in increased expression of SNAI1 mRNA	16772331
D012402	Rotenone	Rotenone inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]	17596522
C010327	salinomycin	salinomycin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of SNAI1 mRNA]	26896736
C010327	salinomycin	salinomycin inhibits the reaction [TGFB1 protein results in increased expression of and results in increased activity of SNAI1 protein]	26896736
C010327	salinomycin	salinomycin inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]	30273566
C005705	sanguinarine	sanguinarine results in decreased expression of SNAI1 protein	19063874
C093642	SB 203580	SB 203580 inhibits the reaction [BMP5 protein results in increased expression of SNAI1 mRNA]	15242789
C093642	SB 203580	SB 203580 inhibits the reaction [benz(a)anthracene results in increased expression of SNAI1 mRNA]	21635667
C093642	SB 203580	SB 203580 inhibits the reaction [benzo(k)fluoranthene results in increased expression of SNAI1 mRNA]	21635667
C093642	SB 203580	SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of SNAI1 mRNA]	21635667
C093642	SB 203580	SB 203580 inhibits the reaction [thymoquinone results in decreased expression of SNAI1 protein]	27060453
C417521	SB 216763	SB 216763 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]]	25118938
C417521	SB 216763	SB 216763 inhibits the reaction [Asbestos, Serpentine affects the localization of SNAI1 protein]	26685284
C417521	SB 216763	SB 216763 results in increased expression of SNAI1 protein	23921149
D012834	Silver	Silver results in increased expression of SNAI1 mRNA	26014281
D020123	Sirolimus	Sirolimus inhibits the reaction [sodium arsenite results in increased expression of SNAI1 mRNA]	28888487
D020123	Sirolimus	Sirolimus results in increased expression of SNAI1 protein	28888487
D020123	Sirolimus	NFE2L2 protein promotes the reaction [Sirolimus inhibits the reaction [Paraquat results in increased expression of SNAI1 protein]]	28624451
D020123	Sirolimus	Sirolimus inhibits the reaction [Paraquat results in increased expression of SNAI1 mRNA]	28624451
D020123	Sirolimus	Sirolimus inhibits the reaction [Paraquat results in increased expression of SNAI1 protein]	28624451
D020123	Sirolimus	Sirolimus promotes the reaction [Dibutyl Phthalate results in increased expression of SNAI1 mRNA]	30053495
C009277	sodium arsenate	sodium arsenate affects the methylation of SNAI1 promoter	20667999
C009277	sodium arsenate	sodium arsenate results in increased expression of SNAI1 mRNA	20667999
C017947	sodium arsenite	Sirolimus inhibits the reaction [sodium arsenite results in increased expression of SNAI1 mRNA]	28888487
C017947	sodium arsenite	SNAI1 protein affects the reaction [sodium arsenite results in decreased expression of CDH1 protein]	28888487
C017947	sodium arsenite	SNAI1 protein affects the reaction [sodium arsenite results in increased expression of VIM protein]	28888487
C017947	sodium arsenite	sodium arsenite promotes the reaction [SQSTM1 protein binds to SNAI1 protein]	28888487
C017947	sodium arsenite	[sodium arsenite results in increased activity of RELA protein] which results in increased expression of SNAI1	23069812
C017947	sodium arsenite	sodium arsenite results in increased expression of SNAI1	23069812
C017947	sodium arsenite	sodium arsenite results in increased expression of SNAI1 mRNA	24068038; 28888487;
C017947	sodium arsenite	sodium arsenite results in increased expression of SNAI1 protein	28336213; 28888487;
C017947	sodium arsenite	SQSTM1 protein affects the reaction [sodium arsenite results in increased expression of SNAI1 protein]	28888487
C017947	sodium arsenite	sodium arsenite results in decreased expression of SNAI1 mRNA	23732083
D000077157	Sorafenib	Sorafenib inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]	21360571
D000077157	Sorafenib	Sorafenib inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]	21360571
C016766	sulforafan	sulforafan inhibits the reaction [Paraquat results in increased expression of SNAI1 protein]	28624451
D016559	Tacrolimus	[GSK3A protein co-treated with GSK3B protein] affects the reaction [Tacrolimus results in increased expression of SNAI1 protein]	22416070
D016559	Tacrolimus	Tacrolimus results in increased expression of SNAI1 protein	22416070
D013629	Tamoxifen	3,4',5-trimethoxystilbene promotes the reaction [Tamoxifen results in decreased expression of SNAI1 protein]	23921149
D013629	Tamoxifen	Tamoxifen promotes the reaction [3,4',5-trimethoxystilbene results in decreased expression of SNAI1 protein]	23921149
D013629	Tamoxifen	Tamoxifen results in decreased expression of SNAI1 protein	23921149
C087114	tebuconazole	tebuconazole results in increased expression of SNAI1 mRNA	30458266
D013739	Testosterone	[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI1 mRNA	25164625
D013739	Testosterone	Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of SNAI1 mRNA]	25164625
D013749	Tetrachlorodibenzodioxin	pifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SNAI1 mRNA]	20064835
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SNAI1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SNAI1 mRNA	15591033; 17586704; 18691609; 24154488;
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SNAI1 protein	24154488
D013755	Tetradecanoylphorbol Acetate	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]	25656647
D013755	Tetradecanoylphorbol Acetate	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]	25656647
D013755	Tetradecanoylphorbol Acetate	3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]	25656647
D013755	Tetradecanoylphorbol Acetate	antroquinonol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]	25656647
D013755	Tetradecanoylphorbol Acetate	Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]	25656647
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein	25656647
C034269	tetraethylenepentamine	tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of and affects the localization of SNAI1 protein]	26174737
C034269	tetraethylenepentamine	tetraethylenepentamine results in decreased expression of SNAI1 protein	26174737
C009438	tetrandrine	tetrandrine results in decreased expression of SNAI1 protein	30549224
C003466	thymoquinone	pyrazolanthrone inhibits the reaction [thymoquinone results in decreased expression of SNAI1 protein]	27060453
C003466	thymoquinone	SB 203580 inhibits the reaction [thymoquinone results in decreased expression of SNAI1 protein]	27060453
C003466	thymoquinone	thymoquinone results in decreased expression of SNAI1 protein	27060453
C009495	titanium dioxide	titanium dioxide results in increased expression of SNAI1 mRNA	27760801
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of SNAI1 mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of SNAI1 protein	27087172
C009500	tolfenamic acid	tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]	31381904
C009500	tolfenamic acid	tolfenamic acid inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]	31381904
D019772	Topotecan	[Oxaliplatin co-treated with Topotecan] results in increased expression of SNAI1 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of SNAI1 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of SNAI1 mRNA	23830798
D014212	Tretinoin	Tretinoin results in increased expression of SNAI1 mRNA	23724009
D014212	Tretinoin	Tretinoin results in increased expression of SNAI1 mRNA	16604517; 16788091; 17038669;
C012589	trichostatin A	trichostatin A affects the expression of SNAI1 mRNA	28542535
D014260	Triclosan	3,3'-diindolylmethane inhibits the reaction [Triclosan results in increased expression of SNAI1 protein]	28844962
D014260	Triclosan	Fulvestrant inhibits the reaction [Triclosan results in increased expression of SNAI1 protein]	28844962
D014260	Triclosan	Triclosan results in increased expression of SNAI1 protein	28844962
C016805	tris(1,3-dichloro-2-propyl)phosphate	tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SNAI1 mRNA	26179874
C113580	U 0126	U 0126 inhibits the reaction [Aldosterone results in increased expression of SNAI1 mRNA]	17596522
C113580	U 0126	U 0126 inhibits the reaction [FGF16 protein results in increased expression of SNAI1 mRNA]	24253043
C113580	U 0126	[U 0126 co-treated with MK 2206] results in decreased expression of SNAI1 mRNA	30723155
C113580	U 0126	U 0126 results in decreased expression of SNAI1 mRNA	30723155
D014520	Urethane	Urethane results in increased expression of SNAI1 mRNA	28818685
D024483	Vitamin K 3	Vitamin K 3 affects the expression of SNAI1 mRNA	20044591
D024483	Vitamin K 3	Vitamin K 3 results in decreased expression of SNAI1 protein	31238027
C000588914	WJ1376-1	WJ1376-1 inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]	24727557
C000588914	WJ1376-1	WJ1376-1 inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]	24727557
C000588915	WJ1398-1	WJ1398-1 inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]	24727557
C000588915	WJ1398-1	WJ1398-1 inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]	24727557
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of SNAI1 mRNA	18593933

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0013	ADP-ribosylation
KW-0963	Cytoplasm
KW-0217	Developmental protein
KW-0238	DNA-binding
KW-0325	Glycoprotein
KW-1017	Isopeptide bond
KW-0479	Metal-binding
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-0621	Polymorphism
KW-1185	Reference proteome
KW-0677	Repeat
KW-0832	Ubl conjugation
KW-0862	Zinc
KW-0863	Zinc-finger

Interpro

InterPro ID	InterPro Term
IPR036236	Znf_C2H2_sf
IPR013087	Znf_C2H2_type

PROSITE

PROSITE ID	PROSITE Term
PS00028	ZINC_FINGER_C2H2_1
PS50157	ZINC_FINGER_C2H2_2

Pfam

Pfam ID	Pfam Term
PF00096	zf-C2H2

Gene: SNAI1

Basic information

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction