| Tag | Content |
|---|---|
| Uniprot ID | Q02085 |
| Entrez ID | 20613 |
| Genbank protein ID | CAA47675.1; AAA03481.1; AAH34857.1; AAB58054.1; |
| Genbank nucleotide ID | NM_011427.3 |
| Ensembl protein ID | ENSMUSP00000050581 |
| Ensembl nucleotide ID | ENSMUSG00000042821 |
| Gene name | Zinc finger protein SNAI1 |
| Gene symbol | Snai1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E13.5, E14.5, E15.5 |
| Data sources | Manually collected |
| Reference | 17376812 |
| Functional description | Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (By similarity). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (PubMed:24239292). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (PubMed:24239292). Associates with EGR1 and SP1 to mediate 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3'. In addition, may also activate the CDKN2B promoter by itself. |
| Sequence | MPRSFLVRKP SDPRRKPNYS ELQDACVEFT FQQPYDQAHL LAAIPPPEVL NPAASLPTLI 60 WDSLLVPQVR PVAWATLPLR ESPKAVELTS LSDEDSGKSS QPPSPPSPAP SSFSSTSASS 120 LEAEAFIAFP GLGQLPKQLA RLSVAKDPQS RKIFNCKYCN KEYLSLGALK MHIRSHTLPC 180 VCTTCGKAFS RPWLLQGHVR THTGEKPFSC SHCNRAFADR SNLRAHLQTH SDVKRYQCQA 240 CARTFSRMSL LHKHQESGCS GGPR 264 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SNAI1 | 504492 | E1BMI0 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SNAI1 | 102172917 | A0A452EKN0 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SNAI1 | 100071451 | F6Z6C0 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | SNAI1 | 6615 | O95863 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Snai1 | 20613 | Q02085 | CPO | E13.5, E14.5, E15.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | SNAI1 | 745644 | K7BGT3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SNAI1 | A0A287B2D0 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Snai1 | 116490 | Q6AY35 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | ISO |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | ISO |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA |
| GO:0003677 | DNA binding | IBA |
| GO:0003700 | DNA-binding transcription factor activity | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0019900 | kinase binding | ISO |
| GO:0043565 | sequence-specific DNA binding | IDA |
| GO:0046872 | metal ion binding | IEA |
| GO:0070888 | E-box binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISO |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA |
| GO:0001649 | osteoblast differentiation | IEA |
| GO:0001707 | mesoderm formation | IMP |
| GO:0001837 | epithelial to mesenchymal transition | ISO |
| GO:0001837 | epithelial to mesenchymal transition | IDA |
| GO:0001837 | epithelial to mesenchymal transition | IMP |
| GO:0003198 | epithelial to mesenchymal transition involved in endocardial cushion formation | IGI |
| GO:0006355 | regulation of transcription, DNA-templated | IBA |
| GO:0006357 | regulation of transcription by RNA polymerase II | IGI |
| GO:0007498 | mesoderm development | IMP |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition | ISO |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition | IMP |
| GO:0010957 | negative regulation of vitamin D biosynthetic process | ISO |
| GO:0016477 | cell migration | IGI |
| GO:0030335 | positive regulation of cell migration | ISO |
| GO:0030335 | positive regulation of cell migration | IMP |
| GO:0031069 | hair follicle morphogenesis | IDA |
| GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | ISO |
| GO:0045892 | negative regulation of transcription, DNA-templated | IDA |
| GO:0045893 | positive regulation of transcription, DNA-templated | ISO |
| GO:0045893 | positive regulation of transcription, DNA-templated | IDA |
| GO:0060021 | roof of mouth development | IGI |
| GO:0060536 | cartilage morphogenesis | IGI |
| GO:0060707 | trophoblast giant cell differentiation | IDA |
| GO:0060806 | negative regulation of cell differentiation involved in embryonic placenta development | IDA |
| GO:0060972 | left/right pattern formation | IMP |
| GO:0061314 | Notch signaling involved in heart development | IGI |
| GO:0070828 | heterochromatin organization | IMP |
| GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | ISO |
| GO:2000810 | regulation of bicellular tight junction assembly | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005634 | nucleus | IBA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005721 | pericentric heterochromatin | ISO |
| GO:0005721 | pericentric heterochromatin | IDA |
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | IDA |
| GO:0005829 | cytosol | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|
| Keyword ID | Keyword Term |
|---|---|
| KW-0013 | ADP-ribosylation |
| KW-0963 | Cytoplasm |
| KW-0217 | Developmental protein |
| KW-0238 | DNA-binding |
| KW-0325 | Glycoprotein |
| KW-1017 | Isopeptide bond |
| KW-0479 | Metal-binding |
| KW-0539 | Nucleus |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0832 | Ubl conjugation |
| KW-0862 | Zinc |
| KW-0863 | Zinc-finger |
| Pfam ID | Pfam Term |
|---|---|
| PF00096 | zf-C2H2 |