Gene: AKAP8

Basic information

Tag Content
Uniprot ID K7D8I9; A0A2J8LUC7;
Entrez ID 748028
Genbank protein ID JAA03651.1; JAA03652.1; JAA18683.1; JAA29435.1; JAA34410.1;
Genbank nucleotide ID XM_016935347.1
Ensembl protein ID ENSPTRP00000083023
Ensembl nucleotide ID ENSPTRG00000010620
Gene name A kinase (PRKA) anchor protein 8
Gene symbol AKAP8
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MDQGYGGYGA WSAGPANTQG AYGTGVASWQ GYENYNYYGA QNTSVTTSAT YSYGPASWEA 60
AKANDGGLAA GAPAMHMASY GPEPCTDNSD SLIAKINQRL DMMSKEGGRG GSGGGGEGIQ 120
DRESSFRFQP FESYDSRPCL PEHNPYRPSY SYDYEFDLGS DRNGSFGGQY SECRDPARER 180
GSLDGFMRGR GQGRFQDRSN PGTFMRSDPF VPPAASSEPL STPWNELNYV GGRGLGGPSP 240
SRPPPSLFSQ SMAPDYGVMG MQGAGGYDST MPYGCGRSQP RMRDRDRPKR RGFDRFGPDG 300
TGRKRKQFQL YEEPDTKLAR VDSEGDFSEN DDAAGDFRSG DEEFKGEDEF CDSGRQRGEK 360
EDEDEDVKKR REKQRRRDRT RDRAADRIQF ACSVCKFRSF DDEEIQKHLQ SKFHKETLRF 420
ISTKLPDKTV EFLQEYIVNR NKKIEKRRQE LMEKETAKPK PDPFKGIGQE HFFKKIEAAH 480
CLACDMLIPA QPQLLQRHLH SVDHNHNRRL AAEQFKKTSL HVAKSVLNNR HIVKMLEKYL 540
KGEDPFTSET VDPEMEGDDN LGGEDKKETP EEVAADVLAE VITAAVRAVD GEGAPAPESN 600
GEPAEDEGPM DTAEAGSDPQ AEQLLEEQVP CGTAHEKGVP KARSEAAEAG NGAETMAAEA 660
ESAQTRVAPA PAAADAEVEQ TDAESKDAVP TE 692

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologAKAP8A0A3Q1M9C8Bos taurusPredictionMore>>
1:1 orthologAKAP8A0A452DXJ3Capra hircusPredictionMore>>
1:1 orthologAKAP810270O43823Homo sapiensPredictionMore>>
1:1 orthologAkap856399Q9DBR0CPOE14.5Mus musculusPublicationMore>>
1:1 orthologAKAP8748028K7D8I9Pan troglodytesPredictionMore>>
1:1 orthologAkap8116633Q63014Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0000793 condensed chromosome
GO:0001939 female pronucleus
GO:0016363 nuclear matrix
GO:0005730 nucleolus
GO:0005654 nucleoplasm
GO:0003677 DNA binding
GO:0042826 histone deacetylase binding
GO:0016301 kinase activity
GO:0051059 NF-kappaB binding
GO:0034237 protein kinase A regulatory subunit binding
GO:0044839 cell cycle G2/M phase transition
GO:0071222 cellular response to lipopolysaccharide
GO:0071380 cellular response to prostaglandin E stimulus
GO:0007076 mitotic chromosome condensation
GO:0032720 negative regulation of tumor necrosis factor production
GO:0031065 positive regulation of histone deacetylation
GO:0033127 regulation of histone phosphorylation

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0418 Kinase
KW-0479 Metal-binding
KW-1185 Reference proteome
KW-0808 Transferase
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR007071 AKAP95
IPR034736 ZF_C2H2_AKAP95

PROSITE

PROSITE ID PROSITE Term
PS51799 ZF_C2H2_AKAP95

Pfam

Pfam ID Pfam Term
PF04988 AKAP95