| Tag | Content |
|---|---|
| Uniprot ID | O35317; Q925W2; |
| Entrez ID | 18516 |
| Genbank protein ID | AAH57879.1; AAB71194.1; AAB71195.1; |
| Genbank nucleotide ID | NM_016768.2; NM_001290576.1; |
| Ensembl protein ID | ENSMUSP00000045281; ENSMUSP00000108757; |
| Ensembl nucleotide ID | ENSMUSG00000038718 |
| Gene name | Pre-B-cell leukemia transcription factor 3 |
| Gene symbol | Pbx3 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO,CLP |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 21982646 |
| Functional description | Transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. |
| Sequence | MDDQSRMLQT LAGVNLAGHS VQGGMALPPP PHGHEGADGD GRKQDIGDIL HQIMTITDQS 60 LDEAQAKKHA LNCHRMKPAL FSVLCEIKEK TGLSIRGAQE EDPPDPQLMR LDNMLLAEGV 120 SGPEKGGGSA AAAAAAAASG GSSDNSIEHS DYRAKLTQIR QIYHTELEKY EQACNEFTTH 180 VMNLLREQSR TRPISPKEIE RMVGIIHRKF SSIQMQLKQS TCEAVMILRS RFLDARRKRR 240 NFSKQATEIL NEYFYSHLSN PYPSEEAKEE LAKKCSITVS QVSNWFGNKR IRYKKNIGKF 300 QEEANLYAAK TAVTAAHAVA AAVQNNQTNS PTTPNSGSSG SFNLPNSGDM FMNMQSLNGD 360 SYQGSQVGAN VQSQVDTLRH VINQTGGYSD GLGANSLYSP HNLNANGGWQ DATTPSSVTS 420 PTEGPGSVHS DTSN 434 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PBX3 | 102187055 | A0A452FB25 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PBX3 | 5090 | Q5JS98 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pbx3 | 18516 | O35317 | CPO,CLP | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PBX3 | 464737 | A0A2I3THW7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PBX3 | A0A286ZZ07 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | PBX3 | G1T307 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Pbx3 | 311876 | D4AB31 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | IDA |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA |
| GO:0005515 | protein binding | IPI |
| GO:0043565 | sequence-specific DNA binding | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0002087 | regulation of respiratory gaseous exchange by nervous system process | IMP |
| GO:0007585 | respiratory gaseous exchange by respiratory system | IMP |
| GO:0008344 | adult locomotory behavior | IMP |
| GO:0021516 | dorsal spinal cord development | IMP |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA |
| GO:0048666 | neuron development | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | IDA |
| GO:0005667 | transcription factor complex | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|