| Tag | Content |
|---|---|
| Uniprot ID | P04916 |
| Entrez ID | 25703 |
| Genbank protein ID | AAA42018.1; AAA42020.1; |
| Genbank nucleotide ID | NM_013162.1 |
| Ensembl protein ID | ENSRNOP00000021055 |
| Ensembl nucleotide ID | ENSRNOG00000015518 |
| Gene name | Retinol-binding protein 4 |
| Gene symbol | Rbp4 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues (PubMed:4708098). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (By similarity). |
| Sequence | MEWVWALVLL AALGGGSAER DCRVSSFRVK ENFDKARFSG LWYAIAKKDP EGLFLQDNII 60 AEFSVDEKGH MSATAKGRVR LLSNWEVCAD MVGTFTDTED PAKFKMKYWG VASFLQRGND 120 DHWIIDTDYD TFALQYSCRL QNLDGTCADS YSFVFSRDPN GLTPETRRLV RQRQEELCLE 180 RQYRWIEHNG YCQSRPSRNS L 201 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RBP4 | 281444 | G1K122 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | RBP4 | A0A452FU43 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | RBP4 | 5950 | P02753 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Rbp4 | 19662 | Q00724 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | RBP4 | 450617 | P61641 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | RBP4 | F1SC80 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Rbp4 | 25703 | P04916 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | rbp4 | 30077 | Q9PT95 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0032991 | protein-containing complex |
| GO:0044877 | protein-containing complex binding |
| GO:0016918 | retinal binding |
| GO:0019841 | retinol binding |
| GO:0034632 | retinol transmembrane transporter activity |
| GO:0048738 | cardiac muscle tissue development |
| GO:0050908 | detection of light stimulus involved in visual perception |
| GO:0048562 | embryonic organ morphogenesis |
| GO:0060059 | embryonic retina morphogenesis in camera-type eye |
| GO:0048706 | embryonic skeletal system development |
| GO:0001654 | eye development |
| GO:0048807 | female genitalia morphogenesis |
| GO:0006094 | gluconeogenesis |
| GO:0042593 | glucose homeostasis |
| GO:0007507 | heart development |
| GO:0060347 | heart trabecula formation |
| GO:0030324 | lung development |
| GO:0030277 | maintenance of gastrointestinal epithelium |
| GO:0008584 | male gonad development |
| GO:0060044 | negative regulation of cardiac muscle cell proliferation |
| GO:0051024 | positive regulation of immunoglobulin secretion |
| GO:0032024 | positive regulation of insulin secretion |
| GO:0045471 | response to ethanol |
| GO:0032868 | response to insulin |
| GO:0032526 | response to retinoic acid |
| GO:0060041 | retina development in camera-type eye |
| GO:0042574 | retinal metabolic process |
| GO:0042572 | retinol metabolic process |
| GO:0034633 | retinol transport |
| GO:0007283 | spermatogenesis |
| GO:0060157 | urinary bladder development |
| GO:0060065 | uterus development |
| GO:0060068 | vagina development |
| GO:0071939 | vitamin A import |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00213 | LIPOCALIN |
| Pfam ID | Pfam Term |
|---|---|
| PF00061 | Lipocalin |