Gene: Rbp4

Basic information

Tag Content
Uniprot ID Q00724; P70357; Q566I5;
Entrez ID 19662
Genbank protein ID AAH93529.1; BAB25881.1; BAD16678.1; AAH31809.1; AAB06955.1; AAA63395.1;
Genbank nucleotide ID NM_011255.3; NM_001159487.1;
Ensembl protein ID ENSMUSP00000107954
Ensembl nucleotide ID ENSMUSG00000024990
Gene name Retinol-binding protein 4
Gene symbol Rbp4
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 29892071
Functional description Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
Sequence
MEWVWALVLL AALGGGSAER DCRVSSFRVK ENFDKARFSG LWYAIAKKDP EGLFLQDNII 60
AEFSVDEKGH MSATAKGRVR LLSNWEVCAD MVGTFTDTED PAKFKMKYWG VASFLQRGND 120
DHWIIDTDYD TFALQYSCRL QNLDGTCADS YSFVFSRDPN GLSPETRRLV RQRQEELCLE 180
RQYRWIEHNG YCQSRPSRNS L 201

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologRBP4281444G1K122Bos taurusPredictionMore>>
1:1 orthologRBP4A0A452FU43Capra hircusPredictionMore>>
1:1 orthologRBP45950P02753Homo sapiensPredictionMore>>
1:1 orthologRbp419662Q00724CPOMus musculusPublicationMore>>
1:1 orthologRBP4450617P61641Pan troglodytesPredictionMore>>
1:1 orthologRBP4F1SC80Sus scrofaPredictionMore>>
1:1 orthologRbp425703P04916Rattus norvegicusPredictionMore>>
1:1 orthologrbp430077Q9PT95Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005515 protein bindingIPI
GO:0016918 retinal bindingIEA
GO:0019841 retinol bindingISO
GO:0019841 retinol bindingIDA
GO:0034632 retinol transmembrane transporter activityIEA
GO:0044877 protein-containing complex bindingISO

GO:Biological Process

GO ID GO Term Evidence
GO:0001654 eye developmentISO
GO:0001654 eye developmentIMP
GO:0006094 gluconeogenesisISO
GO:0006094 gluconeogenesisIMP
GO:0007283 spermatogenesisIMP
GO:0007507 heart developmentIMP
GO:0008584 male gonad developmentIMP
GO:0030277 maintenance of gastrointestinal epitheliumISO
GO:0030324 lung developmentIMP
GO:0032024 positive regulation of insulin secretionISO
GO:0032526 response to retinoic acidISO
GO:0032868 response to insulinIMP
GO:0034633 retinol transportISO
GO:0034633 retinol transportIMP
GO:0034633 retinol transportIGI
GO:0042572 retinol metabolic processISO
GO:0042572 retinol metabolic processIGI
GO:0042574 retinal metabolic processIMP
GO:0042593 glucose homeostasisISO
GO:0048562 embryonic organ morphogenesisIMP
GO:0048706 embryonic skeletal system developmentIMP
GO:0048738 cardiac muscle tissue developmentIMP
GO:0048807 female genitalia morphogenesisIMP
GO:0050908 detection of light stimulus involved in visual perceptionIMP
GO:0051024 positive regulation of immunoglobulin secretionIDA
GO:0060041 retina development in camera-type eyeIMP
GO:0060044 negative regulation of cardiac muscle cell proliferationIMP
GO:0060059 embryonic retina morphogenesis in camera-type eyeIMP
GO:0060065 uterus developmentIMP
GO:0060068 vagina developmentIMP
GO:0060157 urinary bladder developmentIMP
GO:0060347 heart trabecula formationIMP
GO:0071939 vitamin A importIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0005615 extracellular spaceISO
GO:0005615 extracellular spaceIDA
GO:0032991 protein-containing complexISO

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-1430728 MetabolismIEA
R-MMU-162582 Signal TransductionIEA
R-MMU-196854 Metabolism of vitamins and cofactorsIEA
R-MMU-2187338 Visual phototransductionIEA
R-MMU-2453902 The canonical retinoid cycle in rods (twilight vision)IEA
R-MMU-372790 Signaling by GPCRIEA
R-MMU-388396 GPCR downstream signallingIEA
R-MMU-418594 G alpha (i) signalling eventsIEA
R-MMU-6806667 Metabolism of fat-soluble vitaminsIEA
R-MMU-975634 Retinoid metabolism and transportIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-0488 Methylation
KW-1185 Reference proteome
KW-0683 Retinol-binding
KW-0964 Secreted
KW-0732 Signal
KW-0813 Transport
KW-0845 Vitamin A

Interpro

InterPro ID InterPro Term
IPR012674 Calycin
IPR022271 Lipocalin_ApoD
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR002449 Retinol-bd/Purpurin

PROSITE

PROSITE ID PROSITE Term
PS00213 LIPOCALIN

Pfam

Pfam ID Pfam Term
PF00061 Lipocalin