| Tag | Content |
|---|---|
| Uniprot ID | P61641 |
| Entrez ID | 450617 |
| Genbank protein ID | BAD16621.1 |
| Genbank nucleotide ID | NM_001045495.1; XM_009458876.2; XM_009458877.2; |
| Ensembl protein ID | ENSPTRP00000004830 |
| Ensembl nucleotide ID | ENSPTRG00000002768 |
| Gene name | Retinol-binding protein 4 |
| Gene symbol | RBP4 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane. |
| Sequence | MKWVWALLLL AALGSGRAER DCRVSSFRVK ENFDKARFSG TWYAMAKKDP EGLFLQDNIV 60 AEFSVDETGQ MSATAKGRVR LLNNWDVCAD MVGTFTDTED PAKFKMKYWG VASFLQKGND 120 DHWIVDTDYD TYAVQYSCRL LNLDGTCADS YSFVFSRDPN GLPPEAQKIV RQRQEELCLA 180 RQYRLIVHNG YCDGRSERNL L 201 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RBP4 | 281444 | G1K122 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | RBP4 | A0A452FU43 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | RBP4 | 5950 | P02753 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Rbp4 | 19662 | Q00724 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | RBP4 | 450617 | P61641 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | RBP4 | F1SC80 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Rbp4 | 25703 | P04916 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | rbp4 | 30077 | Q9PT95 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0016918 | retinal binding |
| GO:0019841 | retinol binding |
| GO:0034632 | retinol transmembrane transporter activity |
| GO:0001654 | eye development |
| GO:0006094 | gluconeogenesis |
| GO:0042593 | glucose homeostasis |
| GO:0030277 | maintenance of gastrointestinal epithelium |
| GO:0032024 | positive regulation of insulin secretion |
| GO:0032526 | response to retinoic acid |
| GO:0042572 | retinol metabolic process |
| GO:0034633 | retinol transport |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00213 | LIPOCALIN |
| Pfam ID | Pfam Term |
|---|---|
| PF00061 | Lipocalin |