Gene: Hoxb7

Basic information

Tag Content
Uniprot ID P09024; A2A9Z9; Q3UW15;
Entrez ID 15415
Genbank protein ID CAA29934.1; CAA32708.1; BAE23104.1; AAA37845.1; AAA88245.1; CAA68494.1;
Genbank nucleotide ID NM_010460.2
Ensembl protein ID ENSMUSP00000040121
Ensembl nucleotide ID ENSMUSG00000038721
Gene name Homeobox protein Hox-B7
Gene symbol Hoxb7
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 8541217
Functional description Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Sequence
MSSLYYANAL FSKYPAASSV FAPGAFPEQT SCAFASNPQR PGYGAGPGAP FSASVQGLYS 60
GGGAMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC PGDPAKAAGA KEQRDSDLAA 120
ESNFRIYPWM RSSGPDRKRG RQTYTRYQTL ELEKEFHYNR YLTRRRRIEI AHTLCLTERQ 180
IKIWFQNRRM KWKKENKTSG PGTTGQDKAE AEEEEEE 217

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologHOXB7F1N1K1Bos taurusPredictionMore>>
1:1 orthologHOXB7608962F6UVS6Canis lupus familiarisPredictionMore>>
1:1 orthologHOXB7102168764A0A452F107Capra hircusPredictionMore>>
1:1 orthologHOXB7100146931F7AGE2Equus caballusPredictionMore>>
1:1 orthologHOXB73217P09629Homo sapiensPredictionMore>>
1:1 orthologHoxb715415P09024CPOMus musculusPublicationMore>>
1:1 orthologHOXB7455191H2QDC3Pan troglodytesPredictionMore>>
1:1 orthologHOXB7100522513F1RWG2Sus scrofaPredictionMore>>
1:1 orthologHoxb7497985P18864Rattus norvegicusPredictionMore>>
1:1 orthologhoxb7a58044Q8AWY9Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA bindingISO
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA bindingIBA
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specificIBA
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specificISO
GO:0003677 DNA bindingIDA

GO:Biological Process

GO ID GO Term Evidence
GO:0009952 anterior/posterior pattern specificationIGI
GO:0009952 anterior/posterior pattern specificationIBA
GO:0009952 anterior/posterior pattern specificationIMP
GO:0030099 myeloid cell differentiationIMP
GO:0045944 positive regulation of transcription by RNA polymerase IIISO
GO:0048704 embryonic skeletal system morphogenesisIGI
GO:0048704 embryonic skeletal system morphogenesisIMP
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesisIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusIBA
GO:0005654 nucleoplasmISO
GO:0005829 cytosolISO
GO:0016604 nuclear bodyISO

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0217 Developmental protein
KW-0238 DNA-binding
KW-0371 Homeobox
KW-0539 Nucleus
KW-1185 Reference proteome
KW-0804 Transcription
KW-0805 Transcription regulation

Interpro

InterPro ID InterPro Term
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa

PROSITE

PROSITE ID PROSITE Term
PS00032 ANTENNAPEDIA
PS00027 HOMEOBOX_1
PS50071 HOMEOBOX_2

Pfam

Pfam ID Pfam Term
PF00046 Homeodomain

Protein-protein interaction

Protein-miRNA interaction