| Tag | Content |
|---|---|
| Uniprot ID | P18911; P20787; Q3UG86; Q62149; Q91VK5; Q91YX2; |
| Entrez ID | 19411 |
| Genbank protein ID | AAA40033.1; CAA33845.1; AAH12923.1; AAA40035.1; AAA40032.1; AAA40036.1; AAA40034.1; AAH13709.1; BAE28323.1; |
| Genbank nucleotide ID | XM_006520650.1; NM_011244.4; NM_001042727.2; XM_011245525.2; |
| Ensembl protein ID | ENSMUSP00000048838; ENSMUSP00000067266; |
| Ensembl nucleotide ID | ENSMUSG00000001288 |
| Gene name | Retinoic acid receptor gamma |
| Gene symbol | Rarg |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 7607067; 7626396; |
| Functional description | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity). Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function. |
| Sequence | MATNKERLFA PGALGPGSGY PGAGFPFAFP GALRGSPPFE MLSPSFRGLG QPDLPKEMAS 60 LSVETQSTSS EEMVPSSPSP PPPPRVYKPC FVCNDKSSGY HYGVSSCEGC KGFFRRSIQK 120 NMVYTCHRDK NCIINKVTRN RCQYCRLQKC FEVGMSKEAV RNDRNKKKKE VKEEGSPDSY 180 ELSPQLEELI TKVSKAHQET FPSLCQLGKY TTNSSADHRV QLDLGLWDKF SELATKCIIK 240 IVEFAKRLPG FTGLSIADQI TLLKAACLDI LMLRICTRYT PEQDTMTFSD GLTLNRTQMH 300 NAGFGPLTDL VFAFAGQLLP LEMDDTETGL LSAICLICGD RMDLEEPEKV DKLQEPLLEA 360 LRLYARRRRP SQPYMFPRML MKITDLRGIS TKGAERAITL KMEIPGPMPP LIREMLENPE 420 MFEDDSSKPG PHPKASSEDE APGGQGKRGQ SPQPDQGP 458 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RARG | 540425 | Q08DD4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | RARG | 102178513 | A0A452FTP1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RARG | 5916 | P13631 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Rarg | 19411 | P18911 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | RARG | A0A2I3T1N3 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Rarg | 685072 | D3ZF61 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IBA |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IBA |
| GO:0003677 | DNA binding | IDA |
| GO:0003700 | DNA-binding transcription factor activity | IDA |
| GO:0003707 | steroid hormone receptor activity | IEA |
| GO:0004879 | nuclear receptor activity | ISO |
| GO:0005515 | protein binding | IPI |
| GO:0008134 | transcription factor binding | IBA |
| GO:0008270 | zinc ion binding | IEA |
| GO:0030374 | nuclear receptor transcription coactivator activity | IBA |
| GO:0038023 | signaling receptor activity | IBA |
| GO:0046965 | retinoid X receptor binding | IMP |
| GO:0098531 | ligand-activated transcription factor activity | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA |
| GO:0001843 | neural tube closure | IGI |
| GO:0002063 | chondrocyte development | IMP |
| GO:0002068 | glandular epithelial cell development | IGI |
| GO:0003417 | growth plate cartilage development | IGI |
| GO:0003430 | growth plate cartilage chondrocyte growth | IMP |
| GO:0007275 | multicellular organism development | IBA |
| GO:0008284 | positive regulation of cell population proliferation | ISO |
| GO:0008285 | negative regulation of cell population proliferation | IGI |
| GO:0009755 | hormone-mediated signaling pathway | IBA |
| GO:0009952 | anterior/posterior pattern specification | IGI |
| GO:0009952 | anterior/posterior pattern specification | IMP |
| GO:0010468 | regulation of gene expression | IGI |
| GO:0010628 | positive regulation of gene expression | IDA |
| GO:0030154 | cell differentiation | IBA |
| GO:0031076 | embryonic camera-type eye development | IGI |
| GO:0031641 | regulation of myelination | ISO |
| GO:0032331 | negative regulation of chondrocyte differentiation | IMP |
| GO:0032526 | response to retinoic acid | ISO |
| GO:0032526 | response to retinoic acid | IBA |
| GO:0033993 | response to lipid | IBA |
| GO:0035116 | embryonic hindlimb morphogenesis | IGI |
| GO:0035264 | multicellular organism growth | IGI |
| GO:0043065 | positive regulation of apoptotic process | IGI |
| GO:0043068 | positive regulation of programmed cell death | IGI |
| GO:0043401 | steroid hormone mediated signaling pathway | IEA |
| GO:0045596 | negative regulation of cell differentiation | IMP |
| GO:0045637 | regulation of myeloid cell differentiation | IGI |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IDA |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IGI |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IC |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA |
| GO:0048048 | embryonic eye morphogenesis | IGI |
| GO:0048384 | retinoic acid receptor signaling pathway | ISO |
| GO:0048384 | retinoic acid receptor signaling pathway | IBA |
| GO:0048384 | retinoic acid receptor signaling pathway | IMP |
| GO:0048568 | embryonic organ development | IBA |
| GO:0048608 | reproductive structure development | IMP |
| GO:0048732 | gland development | IBA |
| GO:0048732 | gland development | IMP |
| GO:0060173 | limb development | IMP |
| GO:0060173 | limb development | IGI |
| GO:0060324 | face development | IGI |
| GO:0060348 | bone development | IMP |
| GO:0060348 | bone development | IGI |
| GO:0060349 | bone morphogenesis | IGI |
| GO:0060349 | bone morphogenesis | IMP |
| GO:0060349 | bone morphogenesis | IBA |
| GO:0060429 | epithelium development | IBA |
| GO:0060429 | epithelium development | IMP |
| GO:0060534 | trachea cartilage development | IMP |
| GO:0060740 | prostate gland epithelium morphogenesis | IMP |
| GO:0061037 | negative regulation of cartilage development | IMP |
| GO:0070384 | Harderian gland development | IMP |
| GO:0071300 | cellular response to retinoic acid | IBA |
| GO:1990830 | cellular response to leukemia inhibitory factor | IEP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000790 | nuclear chromatin | ISO |
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005634 | nucleus | IBA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005654 | nucleoplasm | TAS |
| GO:0005667 | transcription factor complex | IDA |
| GO:0005737 | cytoplasm | IEA |
| GO:0090575 | RNA polymerase II transcription factor complex | IBA |
| GO:0000790 | nuclear chromatin | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-212436 | Generic Transcription Pathway | IEA |
| R-MMU-383280 | Nuclear Receptor transcription pathway | IEA |
| R-MMU-5362517 | Signaling by Retinoic Acid | IEA |
| R-MMU-73857 | RNA Polymerase II Transcription | IEA |
| R-MMU-74160 | Gene expression (Transcription) | IEA |
| R-MMU-9006931 | Signaling by Nuclear Receptors | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0025 | Alternative splicing |
| KW-0963 | Cytoplasm |
| KW-0238 | DNA-binding |
| KW-1017 | Isopeptide bond |
| KW-0479 | Metal-binding |
| KW-0488 | Methylation |
| KW-0539 | Nucleus |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0804 | Transcription |
| KW-0805 | Transcription regulation |
| KW-0832 | Ubl conjugation |
| KW-0862 | Zinc |
| KW-0863 | Zinc-finger |