Gene: RARG

Basic information

Tag Content
Uniprot ID Q08DD4; F2Z4D7;
Entrez ID 540425
Genbank protein ID AAI23810.2
Genbank nucleotide ID XM_005206170.3; NM_001130756.1;
Ensembl protein ID ENSBTAP00000009984
Ensembl nucleotide ID ENSBTAG00000007592
Gene name RARG protein
Gene symbol RARG
Organism Bos taurus
NCBI taxa ID 9913
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MATNKERLFV PGALGPGSGY PGAGFPFAFP GALRGSPPFE MLSPSFRGLG QPDLPKEMAS 60
LSVETQSTSS EEMVPSSPSP PPPPRVYKPC FVCNDKSSGY HYGVSSCEGC KGFFRRSIQK 120
NMVYTCHRDK NCIINKVTRN RCQYCRLQKC FEVGMSKEAV RNDRNKKKKE VKEEGSLDSY 180
ELSPQLEELI TKVSKAHQET FPSLCQLGKY TTNSSADHRV QLDLGLWDKF SELATKCIIK 240
IVEFAKRLPG FTGLSIADQI TLLKAACLDI LMLRICTRYT PEQDTMTFSD GLTLNRTQMH 300
NAGFGPLTDL VFAFAGQLLP LEMDDTETGL LSAICLICGD RMDLEEPEKV DKLQEPLLEA 360
LRLYARRRRP SQPYMFPRML MKITDLRGIS TKGAERAITL KMEIPGPMPP LIREMLENPE 420
MFEDDSSQPG PHPKASSEDE VPGGQGRGGR SPHPDQGL 458

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologRARG540425Q08DD4Bos taurusPredictionMore>>
1:1 orthologRARG102178513A0A452FTP1Capra hircusPredictionMore>>
1:1 orthologRARG5916P13631Homo sapiensPredictionMore>>
1:1 orthologRarg19411P18911CPOMus musculusPublicationMore>>
1:1 orthologRARGA0A2I3T1N3Pan troglodytesPredictionMore>>
1:1 orthologRarg685072D3ZF61Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0042025 host cell nucleus
GO:0000790 nuclear chromatin
GO:0005654 nucleoplasm
GO:0005634 nucleus
GO:0090575 RNA polymerase II transcription factor complex
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0098531 ligand-activated transcription factor activity
GO:0004879 nuclear receptor activity
GO:0030374 nuclear receptor transcription coactivator activity
GO:0046965 retinoid X receptor binding
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0038023 signaling receptor activity
GO:0003707 steroid hormone receptor activity
GO:0008134 transcription factor binding
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0008270 zinc ion binding
GO:0009952 anterior/posterior pattern specification
GO:0060349 bone morphogenesis
GO:0030154 cell differentiation
GO:1990830 cellular response to leukemia inhibitory factor
GO:0071300 cellular response to retinoic acid
GO:0031076 embryonic camera-type eye development
GO:0048048 embryonic eye morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0048568 embryonic organ development
GO:0060429 epithelium development
GO:0060324 face development
GO:0048732 gland development
GO:0002068 glandular epithelial cell development
GO:0003430 growth plate cartilage chondrocyte growth
GO:0070384 Harderian gland development
GO:0009755 hormone-mediated signaling pathway
GO:0007275 multicellular organism development
GO:0035264 multicellular organism growth
GO:0008285 negative regulation of cell population proliferation
GO:0032331 negative regulation of chondrocyte differentiation
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001843 neural tube closure
GO:0043065 positive regulation of apoptotic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060740 prostate gland epithelium morphogenesis
GO:0045637 regulation of myeloid cell differentiation
GO:0033993 response to lipid
GO:0032526 response to retinoic acid
GO:0048384 retinoic acid receptor signaling pathway
GO:0060534 trachea cartilage development

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0238 DNA-binding
KW-0479 Metal-binding
KW-0539 Nucleus
KW-0675 Receptor
KW-1185 Reference proteome
KW-0804 Transcription
KW-0805 Transcription regulation
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR035500 NHR-like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003078 Retinoic_acid_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA

PROSITE

PROSITE ID PROSITE Term
PS51843 NR_LBD
PS00031 NUCLEAR_REC_DBD_1
PS51030 NUCLEAR_REC_DBD_2

Pfam

Pfam ID Pfam Term
PF00104 Hormone_recep
PF00105 zf-C4