Gene: Kif2a

Basic information

Tag Content
Uniprot ID P28740; O54744; Q91W03;
Entrez ID 16563
Genbank protein ID CAA75815.1; AAH06803.2; BAA02165.1;
Genbank nucleotide ID NM_001145779.1; XM_006517539.3;
Ensembl protein ID ENSMUSP00000022204; ENSMUSP00000112715; ENSMUSP00000113921;
Ensembl nucleotide ID ENSMUSG00000021693
Gene name Kinesin-like protein KIF2A
Gene symbol Kif2a
Organism Mus musculus
NCBI taxa ID 10090
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity).
Sequence
MATANFGKIQ IGIYVEIKRS DGRIHQAMVT SLNEDNESVT VEWIENGDTK GKEIDLESIF 60
SLNPDLVPDE DIEPSPELPP PSSSSKVNKI VKNRRTVAAV KNDPPPRDNR VVGSARARPS 120
QLPEQSSSAQ QNGSVSDISP VQAAKKEFGP PSRRKSNCVK EVEKLQEKRE KRRLQQQELR 180
EKRAQDVDAT NPNYEIMCMI RDFRGSLDYR PLTTADPIDE HRICVCVRKR PLNKKETQMK 240
DLDVITIPSK DVVMVHEPKQ KVDLTRYLEN QTFRFDYAFD DSAPNEMVYR FTARPLVETI 300
FERGMATCFA YGQTGSGKTH TMGGDFSGKN QDCSKGIYAL AARDVFLMLK KPNYKKLELQ 360
VYATFFEIYS GKVFDLLNRK TKLRVLEDGK QQVQVVGLQE REVKCVEDVL KLIDIGNSCR 420
TSGQTSANAH SSRSHAVFQI ILRRKGKLHG KFSLIDLAGN ERGADTSSAD RQTRLEGAEI 480
NKSLLALKEC IRALGRNKPH TPFRASKLTQ VLRDSFIGEN SRTCMIATIS PGMASCENTL 540
NTLRYANRVK ELTVNPAAAG DVHPIMHHPP SQIDDLETQW GVGSSPQRDD LKLLCEQNEE 600
EVSPQLFTFH EAVSQMVEME EQVVEDHRAV FQESIRWIED EKALLEMTEE VDYDVDSYAT 660
QLEAILEQKI DILTELRDKV KSFRAALQEE EQASKQINPK RPRAL 705

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologKIF2AG3N277Bos taurusPredictionMore>>
1:1 orthologKIF2AJ9P9X3Canis lupus familiarisPredictionMore>>
1:1 orthologKIF2A102180081A0A452EHH5Capra hircusPredictionMore>>
1:1 orthologKIF2A3796O00139Homo sapiensPublicationMore>>
1:1 orthologKif2a16563P28740Mus musculusPredictionMore>>
1:1 orthologKIF2A100615381K7C9U3Pan troglodytesPredictionMore>>
1:1 orthologKIF2AA0A287ADF2Sus scrofaPredictionMore>>
1:1 orthologKif2aF1M8L1Rattus norvegicusPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0003777 microtubule motor activityIBA
GO:0005524 ATP bindingIEA
GO:0008017 microtubule bindingISO
GO:0008017 microtubule bindingIBA
GO:0016887 ATPase activityIBA
GO:0019901 protein kinase bindingISO

GO:Biological Process

GO ID GO Term Evidence
GO:0000226 microtubule cytoskeleton organizationISO
GO:0007018 microtubule-based movementIBA
GO:0007052 mitotic spindle organizationISS
GO:0007052 mitotic spindle organizationISO
GO:0007399 nervous system developmentIEA
GO:0030154 cell differentiationIEA
GO:0030334 regulation of cell migrationISO
GO:0051301 cell divisionIEA
GO:0090307 mitotic spindle assemblyISS
GO:0090307 mitotic spindle assemblyISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0005654 nucleoplasmISO
GO:0005730 nucleolusISO
GO:0005737 cytoplasmISO
GO:0005764 lysosomeIEA
GO:0005813 centrosomeISO
GO:0005813 centrosomeIBA
GO:0005814 centrioleISO
GO:0005819 spindleIBA
GO:0005871 kinesin complexIBA
GO:0005874 microtubuleIBA
GO:0016604 nuclear bodyISO
GO:0097228 sperm principal pieceIDA
GO:0120103 centriolar subdistal appendageISO
GO:0000922 spindle poleISS
GO:0000922 spindle poleISO
GO:0005874 microtubuleISO
GO:0005876 spindle microtubuleISS
GO:0005876 spindle microtubuleISO

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-109582 HemostasisIEA
R-MMU-1280218 Adaptive Immune SystemIEA
R-MMU-141424 Amplification of signal from the kinetochoresIEA
R-MMU-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalIEA
R-MMU-162582 Signal TransductionIEA
R-MMU-1640170 Cell CycleIEA
R-MMU-168256 Immune SystemIEA
R-MMU-194315 Signaling by Rho GTPasesIEA
R-MMU-195258 RHO GTPase EffectorsIEA
R-MMU-199991 Membrane TraffickingIEA
R-MMU-2132295 MHC class II antigen presentationIEA
R-MMU-2467813 Separation of Sister ChromatidsIEA
R-MMU-2500257 Resolution of Sister Chromatid CohesionIEA
R-MMU-2555396 Mitotic Metaphase and AnaphaseIEA
R-MMU-5653656 Vesicle-mediated transportIEA
R-MMU-5663220 RHO GTPases Activate ForminsIEA
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde trafficIEA
R-MMU-6811442 Intra-Golgi and retrograde Golgi-to-ER trafficIEA
R-MMU-68877 Mitotic PrometaphaseIEA
R-MMU-68882 Mitotic AnaphaseIEA
R-MMU-68886 M PhaseIEA
R-MMU-69278 Cell Cycle, MitoticIEA
R-MMU-69618 Mitotic Spindle CheckpointIEA
R-MMU-69620 Cell Cycle CheckpointsIEA
R-MMU-8856688 Golgi-to-ER retrograde transportIEA
R-MMU-9648025 EML4 and NUDC in mitotic spindle formationIEA
R-MMU-983189 KinesinsIEA
R-MMU-983231 Factors involved in megakaryocyte development and platelet productionIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0025 Alternative splicing
KW-0067 ATP-binding
KW-0131 Cell cycle
KW-0132 Cell division
KW-0175 Coiled coil
KW-0963 Cytoplasm
KW-0206 Cytoskeleton
KW-0217 Developmental protein
KW-0221 Differentiation
KW-0458 Lysosome
KW-0493 Microtubule
KW-0498 Mitosis
KW-0505 Motor protein
KW-0524 Neurogenesis
KW-0547 Nucleotide-binding
KW-0597 Phosphoprotein
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase

PROSITE

PROSITE ID PROSITE Term
PS00411 KINESIN_MOTOR_1
PS50067 KINESIN_MOTOR_2

Pfam

Pfam ID Pfam Term
PF00225 Kinesin

Protein-protein interaction

Protein-miRNA interaction