| Tag | Content |
|---|---|
| Uniprot ID | P30121; Q546J4; |
| Entrez ID | 29543 |
| Genbank protein ID | AAA84581.1; AAA21553.1; AAH84714.1; CAC35060.1; AAC60687.1; AAB49507.1; |
| Genbank nucleotide ID | NM_021989.2 |
| Ensembl protein ID | ENSRNOP00000004290 |
| Ensembl nucleotide ID | ENSRNOG00000003148 |
| Gene name | Metalloproteinase inhibitor 2 |
| Gene symbol | Timp2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. |
| Sequence | MGAAARSLRL ALGLLLLATL LRPADACSCS PVHPQQAFCN ADVVIRAKAV SEKEVDSGND 60 IYGNPIKRIQ YEIKQIKMFK GPDKDIEFIY TAPSSAVCGV SLDVGGKKEY LIAGKAEGDG 120 KMHITLCDFI VPWDTLSITQ KKSLNHRYQM GCECKITRCP MIPCYISSPD ECLWMDWVTE 180 KSINGHQAKF FACIKRSDGS CAWYRGAAPP KQEFLDIEDP |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TIMP2 | 102178107 | A0A452G0J3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TIMP2 | 7077 | P16035 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Timp2 | 21858 | Q6PI17 | E12.5, E13.5, E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | TIMP2 | 743167 | H2RHV1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TIMP2 | 396988 | C0JPM4 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Timp2 | 29543 | P30121 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | timp2a | Q1RLX2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005604 | basement membrane |
| GO:0009986 | cell surface |
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0030426 | growth cone |
| GO:0043005 | neuron projection |
| GO:0043025 | neuronal cell body |
| GO:0008047 | enzyme activator activity |
| GO:0005178 | integrin binding |
| GO:0008191 | metalloendopeptidase inhibitor activity |
| GO:0030414 | peptidase inhibitor activity |
| GO:0002020 | protease binding |
| GO:0008270 | zinc ion binding |
| GO:0007568 | aging |
| GO:0071310 | cellular response to organic substance |
| GO:0007417 | central nervous system development |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0010951 | negative regulation of endopeptidase activity |
| GO:0051045 | negative regulation of membrane protein ectodomain proteolysis |
| GO:1905049 | negative regulation of metallopeptidase activity |
| GO:0045930 | negative regulation of mitotic cell cycle |
| GO:0045861 | negative regulation of proteolysis |
| GO:0046580 | negative regulation of Ras protein signal transduction |
| GO:0045762 | positive regulation of adenylate cyclase activity |
| GO:0043410 | positive regulation of MAPK cascade |
| GO:0045666 | positive regulation of neuron differentiation |
| GO:0043408 | regulation of MAPK cascade |
| GO:0045664 | regulation of neuron differentiation |
| GO:0032487 | regulation of Rap protein signal transduction |
| GO:0034097 | response to cytokine |
| GO:0042493 | response to drug |
| GO:0009725 | response to hormone |
| GO:0010033 | response to organic substance |
| GO:0007283 | spermatogenesis |
| Pfam ID | Pfam Term |
|---|---|
| PF00965 | TIMP |