| Tag | Content |
|---|---|
| Uniprot ID | Q1RLX2 |
| Entrez ID | |
| Genbank protein ID | AAI15245.1; AAI65045.1; AAI25892.1; |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000081499 |
| Ensembl nucleotide ID | ENSDARG00000061226 |
| Gene name | Metalloproteinase inhibitor 2 |
| Gene symbol | timp2a |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MKSVRSCIGT LVVLVLFRVG EIAEACSCSP VHPQQAFCNA DVVIRAKVVG KKEVDSGNDI 60 YGNPIKRIQY EIKQIKMFKG PDRHIDVVFT APSSAVCGVT NLDTNGKKEY LISGKAEANG 120 KMHVTLCDLI MPWESMSATQ KKSLSQRYQM GCDCKITRCA TFPCEISAPE ECLWTDWVTE 180 KIIHGRQSDH YACIKRGDGS CAWYRGVAPP KKEFLDVEDP |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TIMP2 | 102178107 | A0A452G0J3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | TIMP2 | 7077 | P16035 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Timp2 | 21858 | Q6PI17 | E12.5, E13.5, E14.5 | Mus musculus | Prediction | More>> | |
| 1:1 ortholog | TIMP2 | 743167 | H2RHV1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TIMP2 | 396988 | C0JPM4 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | Timp2 | 29543 | P30121 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | timp2a | Q1RLX2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0046872 | metal ion binding |
| GO:0008191 | metalloendopeptidase inhibitor activity |
| GO:0002020 | protease binding |
| GO:0010951 | negative regulation of endopeptidase activity |
| GO:0051045 | negative regulation of membrane protein ectodomain proteolysis |
| GO:0034097 | response to cytokine |
| GO:0009725 | response to hormone |
| GO:0010033 | response to organic substance |
| Pfam ID | Pfam Term |
|---|---|
| PF00965 | TIMP |