| Tag | Content |
|---|---|
| Uniprot ID | P32443; Q544T6; |
| Entrez ID | 17286 |
| Genbank protein ID | BAE25163.1; CAA78899.1; BAC25898.1; BAC27282.1; |
| Genbank nucleotide ID | NM_008584.3 |
| Ensembl protein ID | ENSMUSP00000043587 |
| Ensembl nucleotide ID | ENSMUSG00000036144 |
| Gene name | Homeobox protein MOX-2 |
| Gene symbol | Meox2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E12.5, E13.5, E14.0, E14.5 |
| Data sources | Manually collected |
| Reference | 16284941; 10403250; |
| Functional description | Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle. |
| Sequence | MEHPLFGCLR SPHATAQGLH PFSQSSLALH GRSDHMSYPE LSTSSSSCII AGYPNEEGMF 60 ASQHHRGHHH HHHHHHHHHQ QQQHQALQSN WHLPQMSSPP SAARHSLCLQ PDSGGPPELG 120 SSPPVLCSNS SSLGSSTPTG AACAPGDYGR QALSPADVEK RSGSKRKSDS SDSQEGNYKS 180 EVNSKPRKER TAFTKEQIRE LEAEFAHHNY LTRLRRYEIA VNLDLTERQV KVWFQNRRMK 240 WKRVKGGQQG AAAREKELVN VKKGTLLPSE LSGIGAATLQ QTGDSLANED SRDSDHSSEH 300 AHL 303 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MEOX2 | 518540 | A5D7C5 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | AGMO | E2RDU9 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | MEOX2 | 102177402 | A0A452EJ65 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MEOX2 | 4223 | P50222 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Meox2 | 17286 | P32443 | CPO | E12.5, E13.5, E14.0, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | MEOX2 | 463273 | H2QU74 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MEOX2 | F1SEJ3 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | MEOX2 | 100355333 | G1TP72 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Meox2 | G3V6T9 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | meox2a | 556898 | E7FEH1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | ISO |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | ISO |
| GO:0003700 | DNA-binding transcription factor activity | ISS |
| GO:0003700 | DNA-binding transcription factor activity | ISO |
| GO:0043565 | sequence-specific DNA binding | ISO |
| GO:0043565 | sequence-specific DNA binding | ISS |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001525 | angiogenesis | IMP |
| GO:0001757 | somite specification | IGI |
| GO:0007519 | skeletal muscle tissue development | IMP |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | ISO |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA |
| GO:0060021 | roof of mouth development | IMP |
| GO:0060173 | limb development | IMP |
| GO:0061053 | somite development | IBA |
| GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | ISS |
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IBA |
| GO:0005737 | cytoplasm | ISO |
| GO:0016607 | nuclear speck | IEA |
| Reactome ID | Reactome Term | Evidence |
|---|
| Pfam ID | Pfam Term |
|---|---|
| PF00046 | Homeodomain |