Gene: RPL38

Basic information

Tag Content
Uniprot ID P63173; B2R5A8; P23411;
Entrez ID 6169
Genbank protein ID AAH00603.1; BAA25844.1; CAA81488.1; BAG35055.1; EAW89137.1;
Genbank nucleotide ID NM_001035258.1; NM_000999.3;
Ensembl protein ID ENSP00000390279; ENSP00000309830; ENSP00000434243;
Ensembl nucleotide ID ENSG00000172809
Gene name 60S ribosomal protein L38
Gene symbol RPL38
Organism Homo sapiens
NCBI taxa ID 9606
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MPRKIEEIKD FLLTARRKDA KSVKIKKNKD NVKFKVRCSR YLYTLVITDK EKAEKLKQSL 60
PPGLAVKELK

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

  

Gene expression in different tissues (ENCODE)

  

Protein structural annotations

3D structure in PDB database


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Protein disorder information

Protein disorder visualization from D2P2 is currently unavailable.

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologRPL38A0A452G9G0Capra hircusPredictionMore>>
1:1 orthologRPL38100630893F7AB94Equus caballusPredictionMore>>
1:1 orthologRPL386169P63173Homo sapiensPredictionMore>>
1:1 orthologRpl3867671Q9JJI8CPO,CLP,CLOMus musculusPublicationMore>>
1:1 orthologRPL38745405A0A2J8KC40Pan troglodytesPredictionMore>>
1:1 ortholog100516393F2Z568Sus scrofaPredictionMore>>
1:1 orthologrpl38436759Q6DGL9Danio rerioPredictionMore>>

Other genetic variants/mutations

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Disease or phenotype associated information

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0003723 RNA bindingTAS
GO:0003735 structural constituent of ribosomeNAS
GO:0003735 structural constituent of ribosomeIBA

GO:Biological Process

GO ID GO Term Evidence
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decayTAS
GO:0001501 skeletal system developmentIEA
GO:0001503 ossificationIEA
GO:0002181 cytoplasmic translationIDA
GO:0006412 translationNAS
GO:0006413 translational initiationTAS
GO:0006417 regulation of translationIEA
GO:0006614 SRP-dependent cotranslational protein targeting to membraneTAS
GO:0007605 sensory perception of soundIEA
GO:0019083 viral transcriptionTAS
GO:0022618 ribonucleoprotein complex assemblyIBA
GO:0034463 90S preribosome assemblyIEA
GO:0042474 middle ear morphogenesisIEA
GO:0048318 axial mesoderm developmentIEA

GO:Cellular Component

GO ID GO Term Evidence
GO:0005829 cytosolTAS
GO:0005925 focal adhesionHDA
GO:0014069 postsynaptic densityEXP
GO:0014069 postsynaptic densityIDA
GO:0022625 cytosolic large ribosomal subunitHDA
GO:0022625 cytosolic large ribosomal subunitIBA
GO:0022625 cytosolic large ribosomal subunitIDA
GO:0033291 eukaryotic 80S initiation complexIEA
GO:0042788 polysomal ribosomeIDA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-HSA-1266738 Developmental BiologyIEA
R-HSA-1430728 MetabolismIEA
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expressionTAS
R-HSA-156842 Eukaryotic Translation ElongationIEA
R-HSA-156902 Peptide chain elongationIEA
R-HSA-1643685 DiseaseTAS
R-HSA-168254 Influenza InfectionTAS
R-HSA-168255 Influenza Life CycleTAS
R-HSA-168273 Influenza Viral RNA Transcription and ReplicationTAS
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membraneIEA
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membraneTAS
R-HSA-192823 Viral mRNA TranslationTAS
R-HSA-2262752 Cellular responses to stressIEA
R-HSA-2408522 Selenoamino acid metabolismIEA
R-HSA-2408557 Selenocysteine synthesisIEA
R-HSA-376176 Signaling by ROBO receptorsIEA
R-HSA-392499 Metabolism of proteinsTAS
R-HSA-392499 Metabolism of proteinsIEA
R-HSA-422475 Axon guidanceIEA
R-HSA-5663205 Infectious diseaseTAS
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosolTAS
R-HSA-71291 Metabolism of amino acids and derivativesIEA
R-HSA-72312 rRNA processingTAS
R-HSA-72613 Eukaryotic Translation InitiationTAS
R-HSA-72689 Formation of a pool of free 40S subunitsTAS
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunitTAS
R-HSA-72737 Cap-dependent Translation InitiationTAS
R-HSA-72764 Eukaryotic Translation TerminationIEA
R-HSA-72766 TranslationTAS
R-HSA-72766 TranslationIEA
R-HSA-8868773 rRNA processing in the nucleus and cytosolTAS
R-HSA-8953854 Metabolism of RNATAS
R-HSA-8953897 Cellular responses to external stimuliIEA
R-HSA-9010553 Regulation of expression of SLITs and ROBOsIEA
R-HSA-927802 Nonsense-Mediated Decay (NMD)TAS
R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiencyIEA
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)TAS
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)TAS

Drugs and compounds information

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Functional annotations

Keywords

Keyword ID Keyword Term
KW-0002 3D-structure
KW-0007 Acetylation
KW-1017 Isopeptide bond
KW-1185 Reference proteome
KW-0687 Ribonucleoprotein
KW-0689 Ribosomal protein
KW-0832 Ubl conjugation

Interpro

InterPro ID InterPro Term
IPR002675 Ribosomal_L38e
IPR038464 Ribosomal_L38e_sf

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF01781 Ribosomal_L38e

Protein-protein interaction

Protein-miRNA interaction