CleftGeneDB-Search

Gene: Ctnnb1

Basic information

Tag	Content
Uniprot ID	Q02248; Q922W1; Q9D335;
Entrez ID	12387
Genbank protein ID	AAA37280.1; BAC29027.1; BAB31250.1; AAH48153.1; AAH53065.1; AAH06739.1;
Genbank nucleotide ID	NM_001165902.1; NM_007614.3;
Ensembl protein ID	ENSMUSP00000007130; ENSMUSP00000136294;
Ensembl nucleotide ID	ENSMUSG00000006932
Gene name	Catenin beta-1
Gene symbol	Ctnnb1
Organism	Mus musculus
NCBI taxa ID	10090
Cleft type	CPO,CLP
Developmental stage	E14.5
Data sources	Manually collected
Reference	19204372; 21185284; 19631205; 22354888; 21600200; 11262227; 21307168; 21571225;
Functional description	Key downstream component of the canonical Wnt signaling pathway (PubMed:15132997). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (PubMed:16325582, PubMed:18093941). Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (By similarity). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (PubMed:21325504). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (PubMed:15132997).
Sequence	MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG NPEEEDVDTS 60 QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP ETLDEGMQIP STQFDAAHPT 120 NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT RAIPELTKLL NDEDQVVVNK AAVMVHQLSK 180 KEASRHAIMR SPQMVSAIVR TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL 240 VKMLGSPVDS VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC 300 LQILAYGNQE SKLIILASGG PQALVNIMRT YTYEKLLWTT SRVLKVLSVC SSNKPAIVEA 360 GGMQALGLHL TDPSQRLVQN CLWTLRNLSD AATKQEGMEG LLGTLVQLLG SDDINVVTCA 420 AGILSNLTCN NYKNKMMVCQ VGGIEALVRT VLRAGDREDI TEPAICALRH LTSRHQEAEM 480 AQNAVRLHYG LPVVVKLLHP PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL 540 VRAHQDTQRR TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV 600 QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG VATYAAAVLF 660 RMSEDKPQDY KKRLSVELTS SLFRTEPMAW NETADLGLDI GAQGEALGYR QDDPSYRSFH 720 SGGYGQDALG MDPMMEHEMG GHHPGADYPV DGLPDLGHAQ DLMDGLPPGD SNQLAWFDTD 780 L 781

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

Protein structural annotations

3D structure in PDB database

PDB ID
1DOW
1I7W
1I7X
1JPP
1M1E
1V18
2BCT
3BCT
3OUW
3OUX
4EV8
4EV9
4EVA
4EVP
4EVT
4ONS
1DOW
1I7W
1JPP
3OUX
4EV8
4EVP

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Developmental stage	Species	Evidence	Details
1:1 ortholog	CTNNB1	539003	Q0VCX4			Bos taurus	Prediction	More>>
1:1 ortholog	CTNNB1	477032	B6V8E6			Canis lupus familiaris	Prediction	More>>
1:1 ortholog	CTNNB1	102191742	A0A2Z4FR65			Capra hircus	Prediction	More>>
1:1 ortholog	CTNNB1	100055241	B1MV73			Equus caballus	Prediction	More>>
1:1 ortholog	CTNNB1	1499	P35222			Homo sapiens	Prediction	More>>
1:1 ortholog	Ctnnb1	12387	Q02248	CPO,CLP	E14.5	Mus musculus	Publication	More>>
1:1 ortholog	CTNNB1	450183	A0A2I3SBG5			Pan troglodytes	Prediction	More>>
1:1 ortholog	Ctnnb1	84353	A0A0G2JT93			Rattus norvegicus	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs13468608	p.Val438Ala	missense variant	-	NC_000075.6:g.120955456T>C	UniProt

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0001085	RNA polymerase II transcription factor binding	ISO
GO:0001085	RNA polymerase II transcription factor binding	IDA
GO:0001102	RNA polymerase II activating transcription factor binding	ISO
GO:0003682	chromatin binding	IDA
GO:0003682	chromatin binding	IGI
GO:0003700	DNA-binding transcription factor activity	IDA
GO:0003713	transcription coactivator activity	ISO
GO:0003713	transcription coactivator activity	IDA
GO:0003713	transcription coactivator activity	IBA
GO:0003713	transcription coactivator activity	IMP
GO:0005515	protein binding	IPI
GO:0008013	beta-catenin binding	ISO
GO:0008022	protein C-terminus binding	ISO
GO:0008134	transcription factor binding	ISO
GO:0008134	transcription factor binding	IPI
GO:0019899	enzyme binding	ISO
GO:0019899	enzyme binding	IPI
GO:0019900	kinase binding	ISO
GO:0019901	protein kinase binding	IPI
GO:0019903	protein phosphatase binding	ISO
GO:0019903	protein phosphatase binding	IPI
GO:0019903	protein phosphatase binding	IBA
GO:0030331	estrogen receptor binding	ISO
GO:0035255	ionotropic glutamate receptor binding	ISO
GO:0035257	nuclear hormone receptor binding	ISO
GO:0035257	nuclear hormone receptor binding	IPI
GO:0035257	nuclear hormone receptor binding	IBA
GO:0044325	ion channel binding	ISO
GO:0044877	protein-containing complex binding	ISO
GO:0045294	alpha-catenin binding	ISO
GO:0045294	alpha-catenin binding	IDA
GO:0045294	alpha-catenin binding	IPI
GO:0045294	alpha-catenin binding	IBA
GO:0045296	cadherin binding	ISO
GO:0045296	cadherin binding	IPI
GO:0045296	cadherin binding	IBA
GO:0046332	SMAD binding	ISO
GO:0050998	nitric-oxide synthase binding	ISO
GO:0070411	I-SMAD binding	ISO
GO:0070491	repressing transcription factor binding	IPI
GO:0097718	disordered domain specific binding	IPI
GO:1990226	histone methyltransferase binding	NAS

GO:Biological Process

GO ID	GO Term	Evidence
GO:0000122	negative regulation of transcription by RNA polymerase II	IDA
GO:0000209	protein polyubiquitination	ISO
GO:0000578	embryonic axis specification	IDA
GO:0000904	cell morphogenesis involved in differentiation	IMP
GO:0001501	skeletal system development	IMP
GO:0001569	branching involved in blood vessel morphogenesis	IMP
GO:0001570	vasculogenesis	IMP
GO:0001658	branching involved in ureteric bud morphogenesis	IMP
GO:0001701	in utero embryonic development	IMP
GO:0001701	in utero embryonic development	IGI
GO:0001702	gastrulation with mouth forming second	IMP
GO:0001706	endoderm formation	IMP
GO:0001708	cell fate specification	IMP
GO:0001709	cell fate determination	IMP
GO:0001711	endodermal cell fate commitment	IMP
GO:0001764	neuron migration	IGI
GO:0001822	kidney development	IMP
GO:0001840	neural plate development	IDA
GO:0001894	tissue homeostasis	IMP
GO:0001944	vasculature development	IMP
GO:0002052	positive regulation of neuroblast proliferation	IMP
GO:0002052	positive regulation of neuroblast proliferation	IGI
GO:0002053	positive regulation of mesenchymal cell proliferation	IMP
GO:0002089	lens morphogenesis in camera-type eye	IMP
GO:0003223	ventricular compact myocardium morphogenesis	TAS
GO:0003266	regulation of secondary heart field cardioblast proliferation	IDA
GO:0003338	metanephros morphogenesis	IMP
GO:0003340	negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	IDA
GO:0006357	regulation of transcription by RNA polymerase II	IDA
GO:0006357	regulation of transcription by RNA polymerase II	IMP
GO:0007155	cell adhesion	ISS
GO:0007155	cell adhesion	ISO
GO:0007160	cell-matrix adhesion	IMP
GO:0007268	chemical synaptic transmission	IMP
GO:0007398	ectoderm development	IMP
GO:0007403	glial cell fate determination	IDA
GO:0007507	heart development	IMP
GO:0008283	cell population proliferation	IMP
GO:0008284	positive regulation of cell population proliferation	IMP
GO:0008285	negative regulation of cell population proliferation	ISS
GO:0008285	negative regulation of cell population proliferation	ISO
GO:0009948	anterior/posterior axis specification	IMP
GO:0009950	dorsal/ventral axis specification	IMP
GO:0009953	dorsal/ventral pattern formation	IMP
GO:0009954	proximal/distal pattern formation	IMP
GO:0009987	cellular process	IDA
GO:0010468	regulation of gene expression	IMP
GO:0010628	positive regulation of gene expression	IMP
GO:0010629	negative regulation of gene expression	ISO
GO:0010629	negative regulation of gene expression	IMP
GO:0010718	positive regulation of epithelial to mesenchymal transition	ISO
GO:0010718	positive regulation of epithelial to mesenchymal transition	TAS
GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process	ISS
GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process	ISO
GO:0014010	Schwann cell proliferation	ISO
GO:0016331	morphogenesis of embryonic epithelium	IMP
GO:0016525	negative regulation of angiogenesis	IMP
GO:0019827	stem cell population maintenance	TAS
GO:0021819	layer formation in cerebral cortex	IMP
GO:0022009	central nervous system vasculogenesis	IMP
GO:0022405	hair cycle process	IMP
GO:0030097	hemopoiesis	IDA
GO:0030154	cell differentiation	IMP
GO:0030182	neuron differentiation	IMP
GO:0030217	T cell differentiation	IMP
GO:0030316	osteoclast differentiation	IMP
GO:0030324	lung development	IMP
GO:0030539	male genitalia development	IMP
GO:0030856	regulation of epithelial cell differentiation	IMP
GO:0030858	positive regulation of epithelial cell differentiation	IMP
GO:0030900	forebrain development	IMP
GO:0030901	midbrain development	IMP
GO:0030902	hindbrain development	IMP
GO:0030997	regulation of centriole-centriole cohesion	ISS
GO:0030997	regulation of centriole-centriole cohesion	ISO
GO:0031016	pancreas development	IMP
GO:0031069	hair follicle morphogenesis	IMP
GO:0031641	regulation of myelination	IMP
GO:0032212	positive regulation of telomere maintenance via telomerase	IMP
GO:0032331	negative regulation of chondrocyte differentiation	IGI
GO:0032355	response to estradiol	ISS
GO:0032355	response to estradiol	ISO
GO:0033077	T cell differentiation in thymus	IMP
GO:0033234	negative regulation of protein sumoylation	ISS
GO:0033234	negative regulation of protein sumoylation	ISO
GO:0034097	response to cytokine	ISO
GO:0034332	adherens junction organization	IMP
GO:0034333	adherens junction assembly	ISS
GO:0034333	adherens junction assembly	ISO
GO:0034394	protein localization to cell surface	ISS
GO:0034394	protein localization to cell surface	ISO
GO:0034613	cellular protein localization	IMP
GO:0035050	embryonic heart tube development	IMP
GO:0035112	genitalia morphogenesis	IMP
GO:0035115	embryonic forelimb morphogenesis	IDA
GO:0035116	embryonic hindlimb morphogenesis	IMP
GO:0036023	embryonic skeletal limb joint morphogenesis	IGI
GO:0036520	astrocyte-dopaminergic neuron signaling	IMP
GO:0042127	regulation of cell population proliferation	IDA
GO:0042127	regulation of cell population proliferation	IMP
GO:0042129	regulation of T cell proliferation	IMP
GO:0042475	odontogenesis of dentin-containing tooth	IMP
GO:0042733	embryonic digit morphogenesis	IMP
GO:0042733	embryonic digit morphogenesis	IGI
GO:0042981	regulation of apoptotic process	IMP
GO:0043065	positive regulation of apoptotic process	ISS
GO:0043065	positive regulation of apoptotic process	ISO
GO:0043066	negative regulation of apoptotic process	ISO
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO
GO:0043410	positive regulation of MAPK cascade	IGI
GO:0043525	positive regulation of neuron apoptotic process	ISO
GO:0043588	skin development	IMP
GO:0043627	response to estrogen	ISO
GO:0044093	positive regulation of molecular function	IDA
GO:0044334	canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition	ISS
GO:0044334	canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition	ISO
GO:0045453	bone resorption	IGI
GO:0045453	bone resorption	IMP
GO:0045595	regulation of cell differentiation	IDA
GO:0045596	negative regulation of cell differentiation	IMP
GO:0045603	positive regulation of endothelial cell differentiation	IMP
GO:0045667	regulation of osteoblast differentiation	IMP
GO:0045669	positive regulation of osteoblast differentiation	IMP
GO:0045670	regulation of osteoclast differentiation	IMP
GO:0045671	negative regulation of osteoclast differentiation	IMP
GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway	IMP
GO:0045892	negative regulation of transcription, DNA-templated	ISO
GO:0045892	negative regulation of transcription, DNA-templated	IDA
GO:0045892	negative regulation of transcription, DNA-templated	IMP
GO:0045893	positive regulation of transcription, DNA-templated	ISO
GO:0045893	positive regulation of transcription, DNA-templated	IDA
GO:0045893	positive regulation of transcription, DNA-templated	IMP
GO:0045944	positive regulation of transcription by RNA polymerase II	ISS
GO:0045944	positive regulation of transcription by RNA polymerase II	ISO
GO:0045944	positive regulation of transcription by RNA polymerase II	IMP
GO:0045944	positive regulation of transcription by RNA polymerase II	IDA
GO:0045944	positive regulation of transcription by RNA polymerase II	IGI
GO:0045944	positive regulation of transcription by RNA polymerase II	IBA
GO:0045976	negative regulation of mitotic cell cycle, embryonic	IMP
GO:0048096	chromatin-mediated maintenance of transcription	IMP
GO:0048469	cell maturation	IMP
GO:0048469	cell maturation	IDA
GO:0048489	synaptic vesicle transport	IMP
GO:0048513	animal organ development	IMP
GO:0048538	thymus development	IMP
GO:0048599	oocyte development	IGI
GO:0048617	embryonic foregut morphogenesis	IMP
GO:0048643	positive regulation of skeletal muscle tissue development	IMP
GO:0048660	regulation of smooth muscle cell proliferation	ISS
GO:0048660	regulation of smooth muscle cell proliferation	ISO
GO:0048715	negative regulation of oligodendrocyte differentiation	IMP
GO:0050768	negative regulation of neurogenesis	IMP
GO:0050808	synapse organization	IMP
GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO
GO:0051091	positive regulation of DNA-binding transcription factor activity	IDA
GO:0051145	smooth muscle cell differentiation	IMP
GO:0051569	regulation of histone H3-K4 methylation	NAS
GO:0051569	regulation of histone H3-K4 methylation	TAS
GO:0051884	regulation of timing of anagen	IDA
GO:0051973	positive regulation of telomerase activity	IMP
GO:0060038	cardiac muscle cell proliferation	TAS
GO:0060066	oviduct development	IMP
GO:0060070	canonical Wnt signaling pathway	ISO
GO:0060070	canonical Wnt signaling pathway	IDA
GO:0060070	canonical Wnt signaling pathway	IGI
GO:0060070	canonical Wnt signaling pathway	IMP
GO:0060173	limb development	IMP
GO:0060439	trachea morphogenesis	IMP
GO:0060440	trachea formation	IMP
GO:0060441	epithelial tube branching involved in lung morphogenesis	IMP
GO:0060479	lung cell differentiation	IMP
GO:0060484	lung-associated mesenchyme development	IMP
GO:0060485	mesenchyme development	TAS
GO:0060492	lung induction	IMP
GO:0060742	epithelial cell differentiation involved in prostate gland development	IMP
GO:0060769	positive regulation of epithelial cell proliferation involved in prostate gland development	IMP
GO:0060789	hair follicle placode formation	IMP
GO:0060789	hair follicle placode formation	IGI
GO:0060916	mesenchymal cell proliferation involved in lung development	IMP
GO:0060947	cardiac vascular smooth muscle cell differentiation	TAS
GO:0060982	coronary artery morphogenesis	TAS
GO:0060983	epicardium-derived cardiac vascular smooth muscle cell differentiation	TAS
GO:0061047	positive regulation of branching involved in lung morphogenesis	IMP
GO:0061154	endothelial tube morphogenesis	ISS
GO:0061154	endothelial tube morphogenesis	ISO
GO:0061198	fungiform papilla formation	IMP
GO:0061324	canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation	IMP
GO:0061549	sympathetic ganglion development	IMP
GO:0061550	cranial ganglion development	IMP
GO:0070602	regulation of centromeric sister chromatid cohesion	ISO
GO:0070602	regulation of centromeric sister chromatid cohesion	IMP
GO:0071260	cellular response to mechanical stimulus	ISO
GO:0071363	cellular response to growth factor stimulus	ISS
GO:0071363	cellular response to growth factor stimulus	ISO
GO:0071681	cellular response to indole-3-methanol	ISS
GO:0071681	cellular response to indole-3-methanol	ISO
GO:0072033	renal vesicle formation	IMP
GO:0072053	renal inner medulla development	IMP
GO:0072054	renal outer medulla development	IMP
GO:0072079	nephron tubule formation	IMP
GO:0072132	mesenchyme morphogenesis	TAS
GO:0072182	regulation of nephron tubule epithelial cell differentiation	IMP
GO:0090279	regulation of calcium ion import	ISS
GO:0090279	regulation of calcium ion import	ISO
GO:0097091	synaptic vesicle clustering	IDA
GO:0097091	synaptic vesicle clustering	IMP
GO:0098609	cell-cell adhesion	ISO
GO:0098609	cell-cell adhesion	IMP
GO:1901215	negative regulation of neuron death	IGI
GO:1903204	negative regulation of oxidative stress-induced neuron death	IMP
GO:1904173	regulation of histone demethylase activity (H3-K4 specific)	TAS
GO:1904499	regulation of chromatin-mediated maintenance of transcription	NAS
GO:1904501	positive regulation of chromatin-mediated maintenance of transcription	IMP
GO:1904793	regulation of euchromatin binding	IDA
GO:1904796	regulation of core promoter binding	IDA
GO:1904798	positive regulation of core promoter binding	ISO
GO:1904798	positive regulation of core promoter binding	IDA
GO:1904888	cranial skeletal system development	IMP
GO:1904948	midbrain dopaminergic neuron differentiation	IMP
GO:1904954	canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	IC
GO:1990138	neuron projection extension	ISS
GO:1990138	neuron projection extension	ISO
GO:1990314	cellular response to insulin-like growth factor stimulus	ISO
GO:1990403	embryonic brain development	IMP
GO:1990791	dorsal root ganglion development	IMP
GO:2000008	regulation of protein localization to cell surface	ISS
GO:2000008	regulation of protein localization to cell surface	ISO
GO:2000017	positive regulation of determination of dorsal identity	IDA
GO:2000144	positive regulation of DNA-templated transcription, initiation	IMP
GO:2000179	positive regulation of neural precursor cell proliferation	IMP
GO:2001234	negative regulation of apoptotic signaling pathway	IMP
GO:2001234	negative regulation of apoptotic signaling pathway	IGI

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0000922	spindle pole	IEA
GO:0005623	cell	IEA
GO:0005634	nucleus	ISO
GO:0005634	nucleus	IDA
GO:0005634	nucleus	IMP
GO:0005667	transcription factor complex	ISO
GO:0005667	transcription factor complex	IDA
GO:0005719	nuclear euchromatin	ISO
GO:0005719	nuclear euchromatin	IDA
GO:0005737	cytoplasm	ISO
GO:0005737	cytoplasm	IDA
GO:0005813	centrosome	ISO
GO:0005813	centrosome	IDA
GO:0005829	cytosol	ISO
GO:0005829	cytosol	IDA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	ISO
GO:0005886	plasma membrane	IDA
GO:0005911	cell-cell junction	ISO
GO:0005911	cell-cell junction	IDA
GO:0005912	adherens junction	ISO
GO:0005912	adherens junction	IDA
GO:0005912	adherens junction	IBA
GO:0005916	fascia adherens	IDA
GO:0005923	bicellular tight junction	IDA
GO:0005938	cell cortex	ISS
GO:0005938	cell cortex	ISO
GO:0014704	intercalated disc	ISO
GO:0014704	intercalated disc	IDA
GO:0016020	membrane	ISO
GO:0016020	membrane	IDA
GO:0016323	basolateral plasma membrane	ISO
GO:0016323	basolateral plasma membrane	IDA
GO:0016328	lateral plasma membrane	ISO
GO:0016328	lateral plasma membrane	IDA
GO:0016342	catenin complex	ISS
GO:0016342	catenin complex	ISO
GO:0016342	catenin complex	IMP
GO:0016342	catenin complex	IBA
GO:0016342	catenin complex	IDA
GO:0016600	flotillin complex	IDA
GO:0030018	Z disc	IDA
GO:0030027	lamellipodium	IDA
GO:0030054	cell junction	ISS
GO:0030054	cell junction	ISO
GO:0030877	beta-catenin destruction complex	ISS
GO:0030877	beta-catenin destruction complex	ISO
GO:0030877	beta-catenin destruction complex	IDA
GO:0031253	cell projection membrane	IDA
GO:0031528	microvillus membrane	IDA
GO:0031965	nuclear membrane	ISO
GO:0032991	protein-containing complex	ISO
GO:0032993	protein-DNA complex	ISS
GO:0032993	protein-DNA complex	ISO
GO:0034750	Scrib-APC-beta-catenin complex	IDA
GO:0042734	presynaptic membrane	IDA
GO:0043198	dendritic shaft	ISO
GO:0043296	apical junction complex	IDA
GO:0044798	nuclear transcription factor complex	IDA
GO:0045177	apical part of cell	IDA
GO:0045202	synapse	ISO
GO:0045202	synapse	IDA
GO:0045211	postsynaptic membrane	IDA
GO:0048471	perinuclear region of cytoplasm	ISS
GO:0048471	perinuclear region of cytoplasm	ISO
GO:0070369	beta-catenin-TCF7L2 complex	ISS
GO:0070369	beta-catenin-TCF7L2 complex	ISO
GO:0071944	cell periphery	ISS
GO:0071944	cell periphery	ISO
GO:0098685	Schaffer collateral - CA1 synapse	IDA
GO:0098685	Schaffer collateral - CA1 synapse	IMP
GO:0098831	presynaptic active zone cytoplasmic component	IDA
GO:0099092	postsynaptic density, intracellular component	IDA
GO:1990907	beta-catenin-TCF complex	ISO
GO:1990907	beta-catenin-TCF complex	IC
GO:1990907	beta-catenin-TCF complex	IDA
GO:1990909	Wnt signalosome	IDA
GO:0043005	neuron projection	ISO

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-MMU-109581	Apoptosis	IEA
R-MMU-111465	Apoptotic cleavage of cellular proteins	IEA
R-MMU-1266738	Developmental Biology	IEA
R-MMU-1500931	Cell-Cell communication	IEA
R-MMU-162582	Signal Transduction	IEA
R-MMU-168249	Innate Immune System	IEA
R-MMU-168256	Immune System	IEA
R-MMU-1834949	Cytosolic sensors of pathogen-associated DNA	IEA
R-MMU-194138	Signaling by VEGF	IEA
R-MMU-194315	Signaling by Rho GTPases	IEA
R-MMU-195253	Degradation of beta-catenin by the destruction complex	IEA
R-MMU-195258	RHO GTPase Effectors	IEA
R-MMU-195721	Signaling by WNT	IEA
R-MMU-196299	Beta-catenin phosphorylation cascade	IEA
R-MMU-201681	TCF dependent signaling in response to WNT	IEA
R-MMU-201722	Formation of the beta-catenin:TCF transactivating complex	IEA
R-MMU-212436	Generic Transcription Pathway	IEA
R-MMU-3134973	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	IEA
R-MMU-351906	Apoptotic cleavage of cell adhesion proteins	IEA
R-MMU-3769402	Deactivation of the beta-catenin transactivating complex	IEA
R-MMU-3858494	Beta-catenin independent WNT signaling	IEA
R-MMU-4086398	Ca2+ pathway	IEA
R-MMU-418990	Adherens junctions interactions	IEA
R-MMU-421270	Cell-cell junction organization	IEA
R-MMU-4420097	VEGFA-VEGFR2 Pathway	IEA
R-MMU-446728	Cell junction organization	IEA
R-MMU-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	IEA
R-MMU-5218920	VEGFR2 mediated vascular permeability	IEA
R-MMU-525793	Myogenesis	IEA
R-MMU-5357801	Programmed Cell Death	IEA
R-MMU-5626467	RHO GTPases activate IQGAPs	IEA
R-MMU-73857	RNA Polymerase II Transcription	IEA
R-MMU-74160	Gene expression (Transcription)	IEA
R-MMU-75153	Apoptotic execution phase	IEA
R-MMU-8853884	Transcriptional Regulation by VENTX	IEA
R-MMU-8878159	Transcriptional regulation by RUNX3	IEA
R-MMU-8951430	RUNX3 regulates WNT signaling	IEA
R-MMU-9006934	Signaling by Receptor Tyrosine Kinases	IEA

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0007	Acetylation
KW-0010	Activator
KW-0130	Cell adhesion
KW-0965	Cell junction
KW-1003	Cell membrane
KW-0966	Cell projection
KW-0963	Cytoplasm
KW-0206	Cytoskeleton
KW-0325	Glycoprotein
KW-0472	Membrane
KW-0524	Neurogenesis
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-1185	Reference proteome
KW-0677	Repeat
KW-0702	S-nitrosylation
KW-0770	Synapse
KW-0804	Transcription
KW-0805	Transcription regulation
KW-0832	Ubl conjugation
KW-0879	Wnt signaling pathway

Interpro

InterPro ID	InterPro Term
IPR011989	ARM-like
IPR016024	ARM-type_fold
IPR000225	Armadillo
IPR013284	Beta-catenin

PROSITE

PROSITE ID	PROSITE Term
PS50176	ARM_REPEAT

Pfam

Pfam ID	Pfam Term
PF00514	Arm

Gene: Ctnnb1

Basic information

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

Other genetic variants/mutations

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction