Gene: CTNNB1

Basic information

Tag Content
Uniprot ID Q0VCX4; A7E3R2;
Entrez ID 539003
Genbank protein ID AAI19950.1; ABS44999.1;
Genbank nucleotide ID XM_005222524.3; NM_001076141.1; XM_005222523.3; XM_005222525.3;
Ensembl protein ID ENSBTAP00000021838
Ensembl nucleotide ID ENSBTAG00000016420
Gene name Catenin beta-1
Gene symbol CTNNB1
Organism Bos taurus
NCBI taxa ID 9913
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (By similarity). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity).
Sequence
MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG NPEEEDVDTT 60
QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP ETLDEGMQIP STQFDAAHPT 120
NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT RAIPELTKLL NDEDQVVVNK AAVMVHQLSK 180
KEASRHAIMR SPQMVSAIVR TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL 240
VKMLGSPVDS VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC 300
LQILAYGNQE SKLIILASGG PQALVNIMRT YTYEKLLWTT SRVLKVLSVC SSNKPAIVEA 360
GGMQALGLHL TDPSQRLVQN CLWTLRNLSD AATKQEGMEG LLGTLVQLLG SDDINVVTCA 420
AGILSNLTCN NYKNKMMVCQ VGGIEALVRT VLRAGDREDI TEPAICALRH LTSRHQEAEM 480
AQNAVRLHYG LPVVVKLLHP PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL 540
VRAHQDTQRR TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV 600
QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG VATYAAAVLF 660
RMSEDKPQDY KKRLSVELTS SLFRTEPMAW NETADLGLDI GAQGEPLGYR QDDPSYRSFH 720
SGGYGQDALG MDPMMEHEMG GHHPGADYPV DGLPDLGHAQ DLMDGLPPGD SNQLAWFDTD 780
L 781

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologCTNNB1539003Q0VCX4Bos taurusPredictionMore>>
1:1 orthologCTNNB1477032B6V8E6Canis lupus familiarisPredictionMore>>
1:1 orthologCTNNB1102191742A0A2Z4FR65Capra hircusPredictionMore>>
1:1 orthologCTNNB1100055241B1MV73Equus caballusPredictionMore>>
1:1 orthologCTNNB11499P35222Homo sapiensPredictionMore>>
1:1 orthologCtnnb112387Q02248CPO,CLPE14.5Mus musculusPublicationMore>>
1:1 orthologCTNNB1450183A0A2I3SBG5Pan troglodytesPredictionMore>>
1:1 orthologCtnnb184353A0A0G2JT93Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005912 adherens junction
GO:0045177 apical part of cell
GO:0016323 basolateral plasma membrane
GO:0030877 beta-catenin destruction complex
GO:0070369 beta-catenin-TCF7L2 complex
GO:0005923 bicellular tight junction
GO:0016342 catenin complex
GO:0005623 cell
GO:0005938 cell cortex
GO:0030054 cell junction
GO:0071944 cell periphery
GO:0005911 cell-cell junction
GO:0005813 centrosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005916 fascia adherens
GO:0016600 flotillin complex
GO:0030027 lamellipodium
GO:0016328 lateral plasma membrane
GO:0016020 membrane
GO:0031528 microvillus membrane
GO:0005719 nuclear euchromatin
GO:0005634 nucleus
GO:0048471 perinuclear region of cytoplasm
GO:0005886 plasma membrane
GO:0099092 postsynaptic density, intracellular component
GO:0045211 postsynaptic membrane
GO:0098831 presynaptic active zone cytoplasmic component
GO:0042734 presynaptic membrane
GO:0032993 protein-DNA complex
GO:0098685 Schaffer collateral - CA1 synapse
GO:0034750 Scrib-APC-beta-catenin complex
GO:0000922 spindle pole
GO:0045202 synapse
GO:0005667 transcription factor complex
GO:1990909 Wnt signalosome
GO:0030018 Z disc
GO:0045294 alpha-catenin binding
GO:0008013 beta-catenin binding
GO:0045296 cadherin binding
GO:0003682 chromatin binding
GO:0097718 disordered domain specific binding
GO:0003700 DNA-binding transcription factor activity
GO:0030331 estrogen receptor binding
GO:0070411 I-SMAD binding
GO:0044325 ion channel binding
GO:0035257 nuclear hormone receptor binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0070491 repressing transcription factor binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0003713 transcription coactivator activity
GO:0034333 adherens junction assembly
GO:0009948 anterior/posterior axis specification
GO:0036520 astrocyte-dopaminergic neuron signaling
GO:0045453 bone resorption
GO:0001569 branching involved in blood vessel morphogenesis
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0060070 canonical Wnt signaling pathway
GO:0061324 canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0044334 canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0007155 cell adhesion
GO:0001708 cell fate specification
GO:0048469 cell maturation
GO:0000904 cell morphogenesis involved in differentiation
GO:0098609 cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0071363 cellular response to growth factor stimulus
GO:0071681 cellular response to indole-3-methanol
GO:0022009 central nervous system vasculogenesis
GO:0007268 chemical synaptic transmission
GO:0048096 chromatin-mediated maintenance of transcription
GO:0061550 cranial ganglion development
GO:1904888 cranial skeletal system development
GO:1990791 dorsal root ganglion development
GO:0009950 dorsal/ventral axis specification
GO:0007398 ectoderm development
GO:0000578 embryonic axis specification
GO:1990403 embryonic brain development
GO:0042733 embryonic digit morphogenesis
GO:0048617 embryonic foregut morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035050 embryonic heart tube development
GO:0035116 embryonic hindlimb morphogenesis
GO:0036023 embryonic skeletal limb joint morphogenesis
GO:0001711 endodermal cell fate commitment
GO:0061154 endothelial tube morphogenesis
GO:0060742 epithelial cell differentiation involved in prostate gland development
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0061198 fungiform papilla formation
GO:0001702 gastrulation with mouth forming second
GO:0035112 genitalia morphogenesis
GO:0007403 glial cell fate determination
GO:0031069 hair follicle morphogenesis
GO:0060789 hair follicle placode formation
GO:0030902 hindbrain development
GO:0001701 in utero embryonic development
GO:0021819 layer formation in cerebral cortex
GO:0002089 lens morphogenesis in camera-type eye
GO:0060479 lung cell differentiation
GO:0060492 lung induction
GO:0060484 lung-associated mesenchyme development
GO:0030539 male genitalia development
GO:0060916 mesenchymal cell proliferation involved in lung development
GO:0003338 metanephros morphogenesis
GO:1904948 midbrain dopaminergic neuron differentiation
GO:0016525 negative regulation of angiogenesis
GO:2001234 negative regulation of apoptotic signaling pathway
GO:0008285 negative regulation of cell population proliferation
GO:0032331 negative regulation of chondrocyte differentiation
GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0045976 negative regulation of mitotic cell cycle, embryonic
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:1903204 negative regulation of oxidative stress-induced neuron death
GO:0033234 negative regulation of protein sumoylation
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0045892 negative regulation of transcription, DNA-templated
GO:0072079 nephron tubule formation
GO:0001840 neural plate development
GO:0001764 neuron migration
GO:1990138 neuron projection extension
GO:0042475 odontogenesis of dentin-containing tooth
GO:0048599 oocyte development
GO:0030316 osteoclast differentiation
GO:0060066 oviduct development
GO:0031016 pancreas development
GO:0043065 positive regulation of apoptotic process
GO:1904501 positive regulation of chromatin-mediated maintenance of transcription
GO:1904798 positive regulation of core promoter binding
GO:2000017 positive regulation of determination of dorsal identity
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:2000144 positive regulation of DNA-templated transcription, initiation
GO:0045603 positive regulation of endothelial cell differentiation
GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway
GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410 positive regulation of MAPK cascade
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002052 positive regulation of neuroblast proliferation
GO:0043525 positive regulation of neuron apoptotic process
GO:0045669 positive regulation of osteoblast differentiation
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0051973 positive regulation of telomerase activity
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045893 positive regulation of transcription, DNA-templated
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0034394 protein localization to cell surface
GO:0000209 protein polyubiquitination
GO:0009954 proximal/distal pattern formation
GO:0090279 regulation of calcium ion import
GO:0030997 regulation of centriole-centriole cohesion
GO:0070602 regulation of centromeric sister chromatid cohesion
GO:1904793 regulation of euchromatin binding
GO:0031641 regulation of myelination
GO:0072182 regulation of nephron tubule epithelial cell differentiation
GO:2000008 regulation of protein localization to cell surface
GO:0003266 regulation of secondary heart field cardioblast proliferation
GO:0048660 regulation of smooth muscle cell proliferation
GO:0042129 regulation of T cell proliferation
GO:0051884 regulation of timing of anagen
GO:0072053 renal inner medulla development
GO:0072054 renal outer medulla development
GO:0072033 renal vesicle formation
GO:0032355 response to estradiol
GO:0051145 smooth muscle cell differentiation
GO:0061549 sympathetic ganglion development
GO:0050808 synapse organization
GO:0097091 synaptic vesicle clustering
GO:0048489 synaptic vesicle transport
GO:0033077 T cell differentiation in thymus
GO:0048538 thymus development
GO:0060440 trachea formation

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0010 Activator
KW-0130 Cell adhesion
KW-0965 Cell junction
KW-1003 Cell membrane
KW-0966 Cell projection
KW-0963 Cytoplasm
KW-0206 Cytoskeleton
KW-0325 Glycoprotein
KW-0472 Membrane
KW-0524 Neurogenesis
KW-0539 Nucleus
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0677 Repeat
KW-0702 S-nitrosylation
KW-0770 Synapse
KW-0804 Transcription
KW-0805 Transcription regulation
KW-0832 Ubl conjugation
KW-0879 Wnt signaling pathway

Interpro

InterPro ID InterPro Term
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR013284 Beta-catenin

PROSITE

PROSITE ID PROSITE Term
PS50176 ARM_REPEAT

Pfam

Pfam ID Pfam Term
PF00514 Arm