| Tag | Content |
|---|---|
| Uniprot ID | Q05B57 |
| Entrez ID | 539931 |
| Genbank protein ID | AAI22789.1 |
| Genbank nucleotide ID | NM_001080309.2 |
| Ensembl protein ID | ENSBTAP00000027017 |
| Ensembl nucleotide ID | ENSBTAG00000020273 |
| Gene name | Ubiquitin thioesterase OTU1 |
| Gene symbol | YOD1 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation. |
| Sequence | MFGPAKGGHF GVHPAAGCPG GVSQPAAGTK AGPAGVCPVG GRTNAMWRLR CKAKEGTHVL 60 QGLSSRTRVR ELQGQIAAIT GISPGCQRIL VGYPPECLDL SNGDTILEDL PIQSGDMLIV 120 EEDQNRPKTS PAFTKYGAPS YVRETLPVLA RMAVPADNSC LFTSVYYVVE GGVLNPACAP 180 EMRRFIAQIV ASDPDFYSEA ILGKTNEEYC DWIKRDDTWG GAIEISILSK FYQCEICVVD 240 TQTVRIDRFG EDAGYTKRVL LIYDGIHYDP LHLVFPDPDT PPLTIFSSYD DIVLVQALEL 300 ADEARKKRQF TDVNRFTLRC MVCQKGLTGQ AEARDHAKET GHTNFGEV 348 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | YOD1 | 539931 | Q05B57 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | YOD1 | 490268 | E2R1N1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | YOD1 | 102177549 | A0A452EJV7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | YOD1 | 55432 | Q5VVQ6 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Yod1 | 226418 | Q8CB27 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | YOD1 | 469659 | G2HE61 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | YOD1 | 100520400 | F1RTR7 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | YOD1 | U3KMW5 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Yod1 | 363982 | Q32Q05 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | yod1 | 550411 | Q567B1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:1990380 | Lys48-specific deubiquitinase activity |
| GO:0046872 | metal ion binding |
| GO:0003676 | nucleic acid binding |
| GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| GO:0031625 | ubiquitin protein ligase binding |
| GO:0030968 | endoplasmic reticulum unfolded protein response |
| GO:0016236 | macroautophagy |
| GO:1904153 | negative regulation of retrograde protein transport, ER to cytosol |
| GO:0016579 | protein deubiquitination |
| GO:0035871 | protein K11-linked deubiquitination |
| GO:1990167 | protein K27-linked deubiquitination |
| GO:0035523 | protein K29-linked deubiquitination |
| GO:1990168 | protein K33-linked deubiquitination |
| GO:0071108 | protein K48-linked deubiquitination |
| GO:0070536 | protein K63-linked deubiquitination |
| GO:0030433 | ubiquitin-dependent ERAD pathway |
| Pfam ID | Pfam Term |
|---|---|
| PF02338 | OTU |