| Tag | Content |
|---|---|
| Uniprot ID | Q567B1 |
| Entrez ID | 550411 |
| Genbank protein ID | AAH93247.1 |
| Genbank nucleotide ID | NM_001017716.2 |
| Ensembl protein ID | ENSDARP00000003565; ENSDARP00000143479; |
| Ensembl nucleotide ID | ENSDARG00000008542 |
| Gene name | Ubiquitin thioesterase OTU1 |
| Gene symbol | yod1 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. |
| Sequence | MLRLRCKAKN GTHLMQGLTH QSCVQELKDK IEELTGIPCD VQKIMVGYPP SSLDLRNGEA 60 HLKDYPIKSG DTLIVEEEKN KPKPPVQPTV TKGPSFEVTP VVERRVVPAD NSCLFTSVNY 120 VMEGGVYDPA CASEMRGLIA QIVASDPTAY SEAVLGKTNE EYCTWIRRDD TWGGAIEVSI 180 LSKFYQCEIC VVDTQTVRVD RFGEDAGYTK RVLLIYDGIH YDPLQKVLPG SDVPAQTVFS 240 TVDDVILAQA LELADEARRK RQFTDVNRFA LRCMVCQTGL VGQKEAREHA KETGHTNFGE 300 V 301 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | YOD1 | 539931 | Q05B57 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | YOD1 | 490268 | E2R1N1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | YOD1 | 102177549 | A0A452EJV7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | YOD1 | 55432 | Q5VVQ6 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Yod1 | 226418 | Q8CB27 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | YOD1 | 469659 | G2HE61 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | YOD1 | 100520400 | F1RTR7 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | YOD1 | U3KMW5 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Yod1 | 363982 | Q32Q05 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | yod1 | 550411 | Q567B1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0008234 | cysteine-type peptidase activity |
| GO:0046872 | metal ion binding |
| GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| GO:0030968 | endoplasmic reticulum unfolded protein response |
| GO:0016236 | macroautophagy |
| GO:0016579 | protein deubiquitination |
| GO:0035871 | protein K11-linked deubiquitination |
| GO:1990167 | protein K27-linked deubiquitination |
| GO:0035523 | protein K29-linked deubiquitination |
| GO:1990168 | protein K33-linked deubiquitination |
| GO:0071108 | protein K48-linked deubiquitination |
| GO:0070536 | protein K63-linked deubiquitination |
| GO:0030433 | ubiquitin-dependent ERAD pathway |