Gene: Yod1

Basic information

Tag Content
Uniprot ID Q32Q05; Q6IE74;
Entrez ID 363982
Genbank protein ID AAI07905.1; CAE48374.1;
Genbank nucleotide ID NM_001008889.1
Ensembl protein ID ENSRNOP00000031836
Ensembl nucleotide ID ENSRNOG00000025704
Gene name Ubiquitin thioesterase OTU1
Gene symbol Yod1
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation.
Sequence
MFGGAKGGHF GVPPAGCSGA VSQAAAGTKA GPAGGRPADT MWRLRCKAKG GTHVLQGLSN 60
RTRLRELQGQ IAAITGIAPG SQRILVGYPP ECLDLSDRDI TLGDLPIQSG DMLIVEEDQT 120
RPKASPAFSK HGAPSYVRET LPVLTRTAVP ADNSCLFTSV YYVVEGGVLN PACAPEMRRL 180
IAQIVASDPD LYSEAILGKT NEEYCDWIRR DDTWGGAIEI SILSKFYQCE ICVVDTQTVR 240
IDRFGEDAGY TKRVLLIYDG IHYDPLQRNF PDPDTPPLTI FSSNDDIVLV QALELADEAR 300
RKRQFTDVNR FTLRCMLCQK GLTGQAEARD HARETGHTNF GEV 343

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologYOD1539931Q05B57Bos taurusPredictionMore>>
1:1 orthologYOD1490268E2R1N1Canis lupus familiarisPredictionMore>>
1:1 orthologYOD1102177549A0A452EJV7Capra hircusPredictionMore>>
1:1 orthologYOD155432Q5VVQ6Homo sapiensPublicationMore>>
1:1 orthologYod1226418Q8CB27Mus musculusPredictionMore>>
1:1 orthologYOD1469659G2HE61Pan troglodytesPredictionMore>>
1:1 orthologYOD1100520400F1RTR7Sus scrofaPredictionMore>>
1:1 orthologYOD1U3KMW5Oryctolagus cuniculusPredictionMore>>
1:1 orthologYod1363982Q32Q05Rattus norvegicusPredictionMore>>
1:1 orthologyod1550411Q567B1Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1990380 Lys48-specific deubiquitinase activity
GO:0046872 metal ion binding
GO:0003676 nucleic acid binding
GO:0004843 thiol-dependent ubiquitin-specific protease activity
GO:0031625 ubiquitin protein ligase binding
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0016236 macroautophagy
GO:1904153 negative regulation of retrograde protein transport, ER to cytosol
GO:0016579 protein deubiquitination
GO:0035871 protein K11-linked deubiquitination
GO:1990167 protein K27-linked deubiquitination
GO:0035523 protein K29-linked deubiquitination
GO:1990168 protein K33-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
GO:0070536 protein K63-linked deubiquitination
GO:0030433 ubiquitin-dependent ERAD pathway

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0963 Cytoplasm
KW-0378 Hydrolase
KW-0479 Metal-binding
KW-0645 Protease
KW-1185 Reference proteome
KW-0788 Thiol protease
KW-0833 Ubl conjugation pathway
KW-0834 Unfolded protein response
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR039138 OTU1_2_3
IPR003323 OTU_dom
IPR038765 Papain-like_cys_pep_sf
IPR029071 Ubiquitin-like_domsf
IPR013087 Znf_C2H2_type

PROSITE

PROSITE ID PROSITE Term
PS50802 OTU
PS00028 ZINC_FINGER_C2H2_1

Pfam

Pfam ID Pfam Term
PF02338 OTU