Gene: Fgf3

Basic information

Tag Content
Uniprot ID Q0VG15
Entrez ID 14174
Genbank protein ID AAI17060.1; AAI17062.1;
Genbank nucleotide ID XM_011241980.2; NM_008007.2;
Ensembl protein ID ENSMUSP00000101518
Ensembl nucleotide ID ENSMUSG00000031074
Gene name Fibroblast growth factor
Gene symbol Fgf3
Organism Mus musculus
NCBI taxa ID 10090
Cleft type
Developmental stage E14.5, E16.5
Data sources Homology search
Reference
Functional description
Sequence
MGLIWLLLLS LLEPSWPTTG PGTRLRRDAG GRGGVYEHLG GAPRRRKLYC ATKYHLQLHP 60
SGRVNGSLEN SAYSILEITA VEVGVVAIKG LFSGRYLAMN KRGRLYASDH YNAECEFVER 120
IHELGYNTYA SRLYRTGSSG PGAQRQPGAQ RPWYVSVNGK GRPRRGFKTR RTQKSSLFLP 180
RVLGHKDHEM VRLLQSSQPR APGEGSQPRQ RRQKKQSPSD HGKMETLSTR ATPSTQLHTG 240
GLAVA 245

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologFGF3108634211A0A452DMM2Capra hircusPredictionMore>>
1:1 orthologFGF32248P11487Homo sapiensPublicationMore>>
1:1 orthologFgf314174Q0VG15E14.5, E16.5Mus musculusPredictionMore>>
1:1 orthologFGF3466693H2Q4B5Pan troglodytesPredictionMore>>
1:1 orthologFgf3170633Q8R5L9Rattus norvegicusPredictionMore>>
1:1 orthologfgf330549P48802Danio rerioPredictionMore>>

Identified variants/mutations related to cleft phenotype

Gene symbol Significant Variants/SNPS Methods PubMed ID
FGF3rs4980700Genotyping24697712

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence

GO:Biological Process

GO ID GO Term Evidence

GO:Cellular Component

GO ID GO Term Evidence

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0339 Growth factor
KW-1185 Reference proteome
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR028232 FGF3
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF

PROSITE

PROSITE ID PROSITE Term
PS00247 HBGF_FGF

Pfam

Pfam ID Pfam Term
PF00167 FGF