| Tag | Content |
|---|---|
| Uniprot ID | Q2KJH6 |
| Entrez ID | 510850 |
| Genbank protein ID | AAI05339.1 |
| Genbank nucleotide ID | XM_005216247.2; NM_001046063.1; XM_005216248.3; |
| Ensembl protein ID | ENSBTAP00000072322; ENSBTAP00000039506; |
| Ensembl nucleotide ID | ENSBTAG00000001027 |
| Gene name | Serpin H1 |
| Gene symbol | SERPINH1 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen (By similarity). |
| Sequence | MRALLLISTI CLLARALAAE VKKPAAAAAP GTAEKLSPKA ATLAERSAGL AFSLYQAMAK 60 DQAVENILLS PVVVASSLGL VSLGGKAATA SQAKAVLSAE QLRDDEVHAG LGELLRSLSN 120 STARNVTWKL GSRLYGPSSV SFAEDFVRSS KQHYNCEHSK INFRDKRSAL QSINEWAAQT 180 TDGKLPEVTK DVERTDGALL VNAMFFKPHW DERFHHKMVD NRGFMVTRSY TVGVTMMHRT 240 GLYNYYDDEK EKLQMVEMPL AHKLSSLIII MPHHVEPLER LEKLLTKEQL KVWMGKMQKK 300 AVAISLPKGV VEVTHDLQKH LAGLGLTEAI DKNKADLSRM SGKKDLYLAS VFHATAFEWD 360 TDGNPFDQDI YGREELRSPK LFYADHPFIF LVRDTQSGSL LFIGRLVRPK GDKMRDEL 418 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | SERPINH1 | 510850 | Q2KJH6 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | SERPINH1 | 485187 | E2RHY7 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | SERPINH1 | 102171265 | A0A452DNR6 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | SERPINH1 | F6PWV8 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | SERPINH1 | 871 | P50454 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Serpinh1 | 12406 | P19324 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | SERPINH1 | 466899 | G2HFZ7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | SERPINH1 | A0A286ZRU9 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Serpinh1 | Q5RJR9 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005783 | endoplasmic reticulum |
| GO:0005788 | endoplasmic reticulum lumen |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| GO:0005615 | extracellular space |
| GO:0045121 | membrane raft |
| GO:0005518 | collagen binding |
| GO:0004867 | serine-type endopeptidase inhibitor activity |
| GO:0051082 | unfolded protein binding |
| GO:0003433 | chondrocyte development involved in endochondral bone morphogenesis |
| GO:0032964 | collagen biosynthetic process |
| GO:0030199 | collagen fibril organization |
| GO:0010951 | negative regulation of endopeptidase activity |
| GO:0051604 | protein maturation |
| Pfam ID | Pfam Term |
|---|---|
| PF00079 | Serpin |