| Tag | Content |
|---|---|
| Uniprot ID | Q4VA53; Q3TNZ4; Q7TSS4; Q80TM8; Q8BJ18; Q8BLH6; Q8BX77; |
| Entrez ID | 100710 |
| Genbank protein ID | AAH96539.1; AAM52216.1; BAC32242.1; BAE37943.1; BAC33427.1; BAC31031.1; BAC65696.1; |
| Genbank nucleotide ID | NM_175310.6; NM_001346503.1; |
| Ensembl protein ID | ENSMUSP00000106112; ENSMUSP00000016569; ENSMUSP00000144572; |
| Ensembl nucleotide ID | ENSMUSG00000034021 |
| Gene name | Sister chromatid cohesion protein PDS5 homolog B |
| Gene symbol | Pds5b |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 17652350 |
| Functional description | Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells (By similarity). |
| Sequence | MAHSKTRTND GKITYPPGVK EISDKISKEE MVRRLKMVVK TFMDMDQDSE EEKELYLNLA 60 LHLASDFFLK HPDKDVRLLV ACCLADIFRI YAPEAPYTSP DKLKDIFMFI TRQLKGLEDT 120 KSPQFNRYFY LLENIAWVKS YNICFELEDS NEIFTQLYRT LFSVINNGHN QKVHMHMVDL 180 MSSIICEGDT VSQELLDTVL VNLVPAHKNL NKQAYDLAKA LLKRTAQAIE PYITNFFNQV 240 LMLGKTSISD LSEHVFDLIL ELYNIDSHLL LSVLPQLEFK LKSNDNEERL QVVKLLAKMF 300 GAKDSELASQ NKPLWQCYLG RFNDIHVPIR LECVKFASHC LMNHPDLAKD LTEYLKVRSH 360 DPEEAIRHDV IVSIVTAAKK DILLVNDHLL NFVRERTLDK RWRVRKEAMM GLAQIYKKYS 420 LQSAAGKDAA KQISWVKDKL LHIYYQNSID DRLLVERIFA QYMVPHNLET TERMKCLYYL 480 YATLDLNAVK ALNEMWKCQN LLRHQVKDLL DLIKQPKTDA SVKAIFSKVM VITRNLPDPG 540 KAQDFMKKFT QVLEDDEKIR KQLEALVSPT CSCKQAEGCV REITKKLGNP KQPTNPFLEM 600 IKFLLERIAP VHIDTESISA LIKQVNKSID GTADDEDEGV PTDQAIRAGL ELLKVLSFTH 660 PISFHSAETF ESLLACLKMD DEKVAEAALQ IFKNTGSKIE EDFPHIRSAL LPVLHHKSKK 720 GPPRQAKYAI HCIHAIFSSK ETQFAQIFEP LHKSLDPSNL EHLITPLVTI GHIALLAPDQ 780 FAAPLKSLVA TFIVKDLLMN DRLPGKKTTK LWVPDEEVSP ETMVKIQAIK MMVRWLLGMK 840 NNHSKSGTST LRLLTTILHS DGDLTEQGKI SKPDMSRLRL AAGSAIVKLA QEPCYHEIIT 900 LEQYQLCALA INDECYQVRQ VFAQKLHKGL SRLRLPLEYM AICALCAKDP VKERRAHARQ 960 CLVKNITVRR EYLKQHAAVS EKLLSLLPEY VVPYTIHLLA HDPDYVKVQD IEQLKDVKEC 1020 LWFVLEILMA KNENNSHAFI RKMVENIKQT KDAQGPDDTK MNEKLYTVCD VAMNIIMSKS 1080 TTYSLESPKD PVLPARFFTQ PDKNFSNTKN YLPPEMKSFF TPGKPKTANV LGAVNKPLSS 1140 AGKQSQTKSS RMETVSNASS SSNPSSPGRI KGRLDSSEMD HSENEDYTMS SPLPGKKSDK 1200 REDPDLSELE KPRSRKKAPV TDPEEKLGMD DLTKLVQEQK PKGSQRGRKR GRTASDSDEQ 1260 QWPEEKRHKE ELLENEDEQN SPPKKGKRGR PPKPLGGGTS KEEPTMKTSK KGNKKKLVPP 1320 VVDDDEEEER QIGNTEHKSK SKQHRTSKRA QQRAESPETS AVESTQSTPQ KGRGRPSKAP 1380 SPSQPPKKIR VGRSKQVATK ENDSSEEMDV LQASSPVSDD TTQEGAEEED ISVGNVRRRS 1440 SKRERR 1446 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PDS5B | F1N7G8 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | PDS5B | 102180403 | A0A452DTE9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PDS5B | 23047 | Q9NTI5 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pds5b | 100710 | Q4VA53 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PDS5B | A0A2I3RL13 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Pds5b | 304218 | D3ZXE2 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | pds5b | 565592 | A0A0R4IP12 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003674 | molecular_function | ND |
| GO:0003677 | DNA binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0002088 | lens development in camera-type eye | IMP |
| GO:0006281 | DNA repair | IBA |
| GO:0007064 | mitotic sister chromatid cohesion | ISS |
| GO:0007064 | mitotic sister chromatid cohesion | ISO |
| GO:0007064 | mitotic sister chromatid cohesion | IBA |
| GO:0008285 | negative regulation of cell population proliferation | ISS |
| GO:0008285 | negative regulation of cell population proliferation | ISO |
| GO:0042127 | regulation of cell population proliferation | ISO |
| GO:0051301 | cell division | IEA |
| GO:0097402 | neuroblast migration | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000785 | chromatin | ISO |
| GO:0000785 | chromatin | IBA |
| GO:0005634 | nucleus | ISS |
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IBA |
| GO:0005654 | nucleoplasm | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1640170 | Cell Cycle | IEA |
| R-MMU-2467813 | Separation of Sister Chromatids | IEA |
| R-MMU-2468052 | Establishment of Sister Chromatid Cohesion | IEA |
| R-MMU-2470946 | Cohesin Loading onto Chromatin | IEA |
| R-MMU-2500257 | Resolution of Sister Chromatid Cohesion | IEA |
| R-MMU-2555396 | Mitotic Metaphase and Anaphase | IEA |
| R-MMU-68877 | Mitotic Prometaphase | IEA |
| R-MMU-68882 | Mitotic Anaphase | IEA |
| R-MMU-68884 | Mitotic Telophase/Cytokinesis | IEA |
| R-MMU-68886 | M Phase | IEA |
| R-MMU-69242 | S Phase | IEA |
| R-MMU-69278 | Cell Cycle, Mitotic | IEA |