| Tag | Content |
|---|---|
| Uniprot ID | Q5E9N2 |
| Entrez ID | 614630 |
| Genbank protein ID | AAX08905.1 |
| Genbank nucleotide ID | XM_010813275.2; NM_001037142.1; XM_005216982.2; |
| Ensembl protein ID | ENSBTAP00000007790; ENSBTAP00000068342; |
| Ensembl nucleotide ID | ENSBTAG00000005933 |
| Gene name | Beta-catenin-interacting protein 1 |
| Gene symbol | CTNNBIP1 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. |
| Sequence | MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTANEEEF LRTYAGVVNS QLSQLPQHSI 60 DQGAEDVVMA FSRSETEDRR Q 81 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | CTNNBIP1 | 614630 | Q5E9N2 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | CLSTN1 | 479600 | E2QVY5 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | CTNNBIP1 | 102173591 | A0A452FWJ1 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | CTNNBIP1 | 56998 | Q9NSA3 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ctnnbip1 | 67087 | Q9JJN6 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | CTNNBIP1 | 749394 | H2R3P1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | CTNNBIP1 | A0A287ADI4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Ctnnbip1 | 503000 | Q4KM58 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ctnnbip1 | 58117 | Q9I903 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0030877 | beta-catenin destruction complex |
| GO:0005829 | cytosol |
| GO:0005634 | nucleus |
| GO:0070016 | armadillo repeat domain binding |
| GO:0008013 | beta-catenin binding |
| GO:0009952 | anterior/posterior pattern specification |
| GO:0001658 | branching involved in ureteric bud morphogenesis |
| GO:0043392 | negative regulation of DNA binding |
| GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| GO:0072201 | negative regulation of mesenchymal cell proliferation |
| GO:0032091 | negative regulation of protein binding |
| GO:0031333 | negative regulation of protein-containing complex assembly |
| GO:0048662 | negative regulation of smooth muscle cell proliferation |
| GO:0060633 | negative regulation of transcription initiation from RNA polymerase II promoter |
| GO:0030178 | negative regulation of Wnt signaling pathway |
| GO:0045657 | positive regulation of monocyte differentiation |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:0002528 | regulation of vascular permeability involved in acute inflammatory response |
| GO:0016055 | Wnt signaling pathway |
| Pfam ID | Pfam Term |
|---|---|
| PF06384 | ICAT |